Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christian Sell"'
Autor:
Christian Sell
Publikováno v:
Molecular Endocrinology. 29:1107-1113
A remarkable plasticity in life span has been uncovered in recent years, offering hope that the basic mechanisms of aging and interventions that delay aging may be identified in the coming decades. Life span extension has been achieved by genetic man
Autor:
Roger McCarter, Christian Sell, Susan M. Motch Perrine, Chad A. Lerner, Yuji Ikeno, Adam B. Salmon
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 308:E545-E553
The extension of lifespan due to reduced insulin-like growth factor 1 (IGF-I) signaling in mice has been proposed to be mediated through alterations in metabolism. Previously, we showed that mice homozygous for an insertion in the Igf1 allele have re
Autor:
Thomas D. Stamato, Silvia Marchionni, Silvana Hrelia, Antonello Lorenzini, Cristina Angeloni, Martine Bocchini, Claudio Stefanelli, Eleonora Croco, Christian Sell
In order to examine potential differences in genomic stability, we have challenged fibroblasts derived from five different mammalian species of variable longevity with the genotoxic agents, etoposide and neocarzinostatin. We report that cells from lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0587e09960a3d76b772c8befccdc2f3a
http://hdl.handle.net/11581/397589
http://hdl.handle.net/11581/397589
Autor:
Claudio Torres, Susan M. Motch, Christian Sell, Roger McCarter, Antonello Lorenzini, Adam B. Salmon, Yuji Ikeno, Chad A. Lerner
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 69:410-419
Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that reducing levels of IGF-1 may also increase life span. However, the data are conflicting and
Autor:
Antonello Lorenzini, Christian Sell, Alessandro Bitto, Silvana Hrelia, Claudio Torres, Elizabeth P. Crowe, Marco Malaguti
Publikováno v:
Experimental Cell Research. 316:2961-2968
There is an increasing awareness that astrocytes, the most abundant cell type in the central nervous system, are critical mediators of brain homeostasis, playing multifunctional roles including buffering potassium ions, maintaining the blood-brain ba
Autor:
Thomas D. Stamato, Jasmine S. Smith, Maria Tresini, F. Brad Johnson, Christian Sell, Antonello Lorenzini, Vincent J. Cristofalo, Anthony Oliver, Mona Hdeib
Publikováno v:
Mechanisms of Ageing and Development. 130:784-792
The identification of the cellular mechanisms responsible for the wide differences in species lifespan remains one of the major unsolved problems of the biology of aging. We measured the capacity of nuclear protein to recognize DNA double strand brea
Publikováno v:
Mechanisms of Ageing and Development. 130:793-800
The insulin-like growth factor type 1 (IGF-I) plays an important role in neuronal physiology. Reduced IGF-I levels are observed during aging and this decrease may be important to age-related changes in the brain. We studied the effects of IGF-I on to
Unexpected activation of mTOR signaling, measured by ribosomal S6 phosphorylation or ribosomal S6 kinase (p70S6K) activity, has been reported in aging-related settings. Evidence of elevated mTOR activity has been reported in the heart and muscle tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f6c3fade42a7715e3084e1bea4a8e8
https://europepmc.org/articles/PMC4589173/
https://europepmc.org/articles/PMC4589173/
Publikováno v:
Experimental Cell Research. 243:326-333
We have created a deletion mutant of the insulin-like growth factor type 1 receptor (IGF-1 R) which lacks the 36 amino acids (aa) immediately N-terminal to the transmembrane domain (Delta870-905 IGF-1 R). This region has been reported to have a negat
Autor:
D Coppola, Raphael Rubin, Christian Sell, Consuelo D'Ambrosio, Masahiko Miura, Andres Ferber, Renato Baserga
Publikováno v:
Molecular and Cellular Biology. 14:4588-4595
When wild-type mouse embryo cells are stably transfected with a plasmid constitutively overexpressing the epidermal growth factor (EGF) receptor (EGFR), the resulting cells can grow in serum-free medium supplemented solely with EGF. Supplementation w