Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christian Gaiddon"'
Autor:
Justine De Azevedo, Jana Mourtada, Cyril Bour, Véronique Devignot, Philippe Schultz, Christian Borel, Erwan Pencreach, Georg Mellitzer, Christian Gaiddon, Alain C. Jung
Publikováno v:
Cells; Volume 11; Issue 18; Pages: 2866
(1) Background: The first line of treatment for recurrent/metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) has recently evolved with the approval of immunotherapies that target the anti-PD-1 immune checkpoint. However, only about 20% of the p
Autor:
Yingying Wang, Mengfei Yao, Isabelle Gross, Linjing Li, Yue Li, Huimin Zou, Yu Liang, Liming Zhu, Xiaoling Weng, Yichao Hou, Danxi Zhu, Lei Li, Christian Gaiddon, Yan Gu, Xin Huang, Yu Wang, Lidan Hou, Xiangjun Meng, Tianqi Wu, Jianhua Wang, Meng Luo
Publikováno v:
Oncogene
Oncogene, 2019, Epub ahead of print]. ⟨10.1038/s41388-019-1035-8⟩
Oncogene, Nature Publishing Group, 2019, Epub ahead of print]. ⟨10.1038/s41388-019-1035-8⟩
Oncogene, 2019, Epub ahead of print]. ⟨10.1038/s41388-019-1035-8⟩
Oncogene, Nature Publishing Group, 2019, Epub ahead of print]. ⟨10.1038/s41388-019-1035-8⟩
The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as a metabolic regulator in the treatment of metabolic diseases; here, DCA was assayed to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37942441fd75783b1dd71fd339aa129
https://www.hal.inserm.fr/inserm-02364194/document
https://www.hal.inserm.fr/inserm-02364194/document
Autor:
Gianni Sava, Alain C. Jung, Pierre Coliat, Ricardo Cerón-Camacho, Cynthia Licona, Ronan Le Lagadec, Jean-Noël Freund, Moussa Ali, Eric Guérin, Christian Gaiddon, Vania Vidimar, Aina Venkatasamy, Dominique Guenot, Michel Pfeffer, Georg Mellitzer
Publikováno v:
Cancer Letters
Cancer Letters, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
Cancer Letters, Elsevier, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
Cancer Letters, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
Cancer Letters, Elsevier, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
International audience; Targeting specific tumor metabolic needs represents an actively investigated therapeutic strategy to bypass tumor resistance mechanisms. In this study, we describe an original approach to impact the cancer metabolism by exploi
Autor:
Samir Benosman, Christian Gaiddon, Isabelle Gross, Koji Okamoto, Aart G. Jochemsen, Clarke N, J P Loeffler
Publikováno v:
Cell Death & Differentiation. 14:2047-2057
MDMX has been shown to modulate p53 in dividing cells after DNA damage. In this study, we investigated the role of MDMX in primary cultures of neurons undergoing cell death. We found that DNA damage, but also membrane-initiated apoptotic stresses (gl
Autor:
Jonathan D. Licht, Olivier Armant, Michèle Kedinger, J L G de Aguilar, Samir Benosman, J-N Freund, Isabelle Gross, Christian Gaiddon, J P Loeffler
Publikováno v:
Cell Death & Differentiation. 14:1802-1812
Sprouty (Spry) proteins are ligand-inducible inhibitors of receptor tyrosine kinases-dependent signaling pathways, which control various biological processes, including proliferation, differentiation and survival. Here, we investigated the regulation
Autor:
Yannick von Grabowiecki, Vania Vidimar, Cynthia Licona, Djalil Coowar, Georg Mellitzer, Paula Abreu, Lavinia Palamiuc, Christian Gaiddon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(1)
Muscular atrophy, a physiopathologic process associated with severe human diseases such as amyotrophic lateral sclerosis (ALS) or cancer, has been linked to reactive oxygen species (ROS) production. The Notch pathway plays a role in muscle developmen
Autor:
Jean-Sébastien Raul, Jean-Philippe Loeffler, Franck Di Scala, Marc de Tapia, Luc Dupuis, Natasa Jokic, Jose-Luis Gonzalez de Aguilar, Bertrand Ludes, Christian Gaiddon
Publikováno v:
Biochemical Journal. 385:125-134
Over the last few years, the widely distributed family of reticulons (RTNs) is receiving renewed interest because of the implication of RTN4/Nogo in neurite regeneration. Four genes were identified in mammals and are referred to as RTN1, 2, 3 and the
Autor:
Bernadette Lutz-Bucher, Christian Gaiddon, Frédérique René, Jon W. Gordon, Jose-Luis Gonzalez de Aguilar, Jean-Philippe Loeffler, Marc de Tapia
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 4, Pp 406-415 (2000)
Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2000, 7 (4), pp.406-415. ⟨10.1006/nbdi.2000.0295⟩
Neurobiology of Disease, 2000, 7 (4), pp.406-415. ⟨10.1006/nbdi.2000.0295⟩
Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2000, 7 (4), pp.406-415. ⟨10.1006/nbdi.2000.0295⟩
Neurobiology of Disease, 2000, 7 (4), pp.406-415. ⟨10.1006/nbdi.2000.0295⟩
International audience; Molecular mechanisms promoting neuronal death in amyotrophic lateral sclerosis (ALS) were investigated using transgenic mice that overexpressed the G86R mutated form of the Cu/Zn superoxide dismutase (SOD1) gene. We observed:
Publikováno v:
Molecular and Cellular Endocrinology. 120:1-8
In the corticotroph cell line AtT20, Ca2+ stimulates c-fos mRNA and nuclear c-fos protein accumulation. We show that Ca2+ stimulates transcription of a chloramphenicol-acetyl-transferase reporter gene driven by the c-fos promoter. This effect is mimi
Autor:
Thierry Cresteil, Laurent Désaubry, Frédéric Thuaud, Nigel Ribeiro, Canan G. Nebigil, Audrey Hild, Patrick P. Michel, Etienne C. Hirsch, Yohann Bernard, Christian Gaiddon
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.10064-10073. ⟨10.1021/jm301201z⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.10064-73. ⟨10.1021/jm301201z⟩
Journal of Medicinal Chemistry, 2012, 55 (22), pp.10064-73. ⟨10.1021/jm301201z⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.10064-10073. ⟨10.1021/jm301201z⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.10064-73. ⟨10.1021/jm301201z⟩
Journal of Medicinal Chemistry, 2012, 55 (22), pp.10064-73. ⟨10.1021/jm301201z⟩
International audience; Flavaglines represent a family of plant natural products that display potent anticancer, cardioprotective, and neuroprotective activities. Novel flavagline derivatives were synthesized and examined for their cytotoxicity on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d3705176e333b7905811ef2230f879
https://hal.archives-ouvertes.fr/hal-02391064
https://hal.archives-ouvertes.fr/hal-02391064