Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Charles R. Mackay"'
Autor:
Kirstine J. Bell, Sonia Saad, Bree J. Tillett, Helen M. McGuire, Sara Bordbar, Yu Anne Yap, Long T. Nguyen, Marc R. Wilkins, Susan Corley, Shannon Brodie, Sussan Duong, Courtney J. Wright, Stephen Twigg, Barbara Fazekas de St Groth, Leonard C. Harrison, Charles R. Mackay, Esteban N. Gurzov, Emma E. Hamilton-Williams, Eliana Mariño
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-21 (2022)
Background Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteria, common
Publikováno v:
Journal of agricultural and food chemistry. 70(20)
Alcohol-related liver disease (ALD) is a major cause of chronic liver disease worldwide with limited therapeutic options. Here, we first revealed the promising beneficial effect of gut microbiota-derived propionate on alcoholic liver injury in mice.
Autor:
Matthew Snelson, Gavin W. Lambert, Assam El-Osta, Grant R Drummond, D. Donner, Melinda T. Coughlan, Helen Kiriazis, Aanthony Vinh, Duncan Horlock, Charles R. Mackay, Waled A. Shihata, Hamdi A. Jama, Beverly Giam, Tim D. Spector, Chad Johnson, Mark Ziemann, Xiao-Jun Du, April Fiedler, Kirill Tsyganov, Francine Z. Marques, David M. Kaye, Sarah E. Phillips, Amrita Vijay, Ana M. Valdes
Publikováno v:
Circulation. 141:1393-1403
Background: High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lac
Autor:
Melinda T. Coughlan, Waled A. Shihata, Louise M Burrell, Charles R. Mackay, Francine Z. Marques, Rikeish R. Muralitharan, Michael E Nakai, Matthew Snelson, David M. Kaye, Hamdi A. Jama, Chad Johnson, Evany Dinakis
Publikováno v:
Hypertension. 77
Autor:
Leigh Donnellan, Mark E. Cooper, Sih Min Tan, Brooke E. Harcourt, Mark Ziemann, Nicole J. Kellow, Josephine M. Forbes, Karly C. Sourris, Melinda T. Coughlan, David Steer, Rachel E. Clarke, Charles R. Mackay, Assam El-Osta, Sally A. Penfold, Tuong-Vi Nguyen, Matthew Snelson, Michael J. Davies, Cassandra de Pasquale, Vicki Thallas-Bonke, Runa S.J. Lindblom, Permal Deo, Trent M. Woodruff
Publikováno v:
Science Advances
Snelson, M, Tan, S M, Clarke, R E, De Pasquale, C, Thallas-Bonke, V, Nguyen, T V, Penfold, S A, Harcourt, B E, Sourris, K C, Lindblom, R S, Ziemann, M, Steer, D, El-Osta, A, Davies, M J, Donnellan, L, Deo, P, Kellow, N J, Cooper, M E, Woodruff, T M, Mackay, C R, Forbes, J M & Coughlan, M T 2021, ' Processed foods drive intestinal barrier permeability and microvascular diseases ', Science Advances, vol. 7, no. 14, eabe4841 . https://doi.org/10.1126/sciadv.abe4841
Snelson, M, Tan, S M, Clarke, R E, De Pasquale, C, Thallas-Bonke, V, Nguyen, T V, Penfold, S A, Harcourt, B E, Sourris, K C, Lindblom, R S, Ziemann, M, Steer, D, El-Osta, A, Davies, M J, Donnellan, L, Deo, P, Kellow, N J, Cooper, M E, Woodruff, T M, Mackay, C R, Forbes, J M & Coughlan, M T 2021, ' Processed foods drive intestinal barrier permeability and microvascular diseases ', Science Advances, vol. 7, no. 14, eabe4841 . https://doi.org/10.1126/sciadv.abe4841
This study shows how highly processed foods can cause innate immune inflammation that promotes chronic microvascular disease.
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular disease
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular disease
Autor:
Yanjun Li, Xiaochen Chen, Yunzi Liu, Tony Kwan, Yik Wen Loh, Steven J. Chadban, Huiling Wu, Julian Singer, Laurence Macia, Jian Tan, Jin Ma, Charles R. Mackay
Publikováno v:
J Am Soc Nephrol
Background Studies have reported "dysbiotic" changes to gut microbiota, such as depletion of gut bacteria that produce short-chain fatty acids (SCFAs) through gut fermentation of fiber, in CKD and diabetes. Dietary fiber is associated with decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e509d83eb26d18d4a7b8c46ff013e92
https://europepmc.org/articles/PMC7269358/
https://europepmc.org/articles/PMC7269358/
Autor:
Yao, He, Liuhui, Fu, Yiping, Li, Wenyan, Wang, Mingli, Gong, Jing, Zhang, Xin, Dong, Jiaoyan, Huang, Quanbo, Wang, Charles R, Mackay, Yang-Xin, Fu, Yun, Chen, Xiaohuan, Guo
Publikováno v:
Cell Reports Medicine
Recent studies in both mice and humans have suggested that gut microbiota could modulate tumor responsiveness to chemo- or immunotherapies. However, the underlying mechanism is not clear yet. Here, we found that gut microbial metabolites, especially
Autor:
Bruno, Jennings-Almeida, Juliana P, Castelpoggi, Erivan S, Ramos-Junior, Eliane de Oliveira, Ferreira, Regina M C P, Domingues, Juliana, Echevarria-Lima, Robson, Coutinho-Silva, Aline C A, Moreira-Souza, Eliana, Mariño, Charles R, Mackay, Dario S, Zamboni, Maria, Bellio, Julio, Scharfstein, Leandro A, Lobo, Ana Carolina, Oliveira
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 206(10)
Intestinal barrier is essential for dietary products and microbiota compartmentalization and therefore gut homeostasis. When this barrier is broken, cecal content overflows into the peritoneal cavity, leading to local and systemic robust inflammatory
Autor:
Liang Xie, Jahangir Alam, Farnaz Fahimi, Charles R. Mackay, Caroline Ang, Marco J Herold, Andrew J. Kueh, Remy Robert, Stephen B. Willingham
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Neutrophils are the most abundant effector cells of the innate immune system and represent the first line of defense against infection. However, in many common pathologies, including autoimmune diseases, excessive recruitment and activation of neutro
Autor:
Karina R. Bortoluci, Sílvio Roberto Consonni, Marcella Rungue, Charles R. Mackay, Jaqueline de Souza Felipe, Brian T. Layden, Cristiane Sécca, Niels Olsen Saraiva Câmara, Laís Passariello Pral, Fabio Takeo Sato, Hosana G. Rodrigues, Ulliana Marques Sampaio, José Luís Fachi, Marco Colonna, Victor de Melo Rocha, Blanda Di Luccia, Patrícia Brito Rodrigues, Maria Teresa Pedrosa Silva Clerici, Angélica T. Vieira, Felipe Cezar Pinheiro de Mato, Marco Aurélio Ramirez Vinolo, Sergio C. Oliveira
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The Journal of Experimental Medicine
Universidade de São Paulo (USP)
instacron:USP
The Journal of Experimental Medicine
Microbiota-derived acetate coordinates innate immune responses during intestinal Clostridium difficile infection through its cognate receptor FFAR2. Acetate accelerates early neutrophil recruitment and increases ILC3 expression of the IL-1 receptor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3bce01b261d6fe3ea8a3e60a3a1594