Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
Autor:
Priya Chatterji, Uma M. Sachdeva, Helen Remotti, Rei Mizuno, Kensuke Suzuki, Anil K. Rustgi, Michael P. Verzi, Sepideh Besharati, Yasunori Masuike, Wenping Sun, Sarah F. Andres, Andres J. Klein-Szanto
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status that is preserved even in metastatic tumors. However, the molecular mechanisms underlying CRC differentiation remain to be elucidated. Herein, we unravel a
Autor:
Kwok-K Wong, Maureen E. Murphy, Jason R. Pitarresi, Mirazul Islam, Gizem Efe, Tatiana A. Karakasheva, Jianhua Hu, Andres J. Klein-Szanto, Jinyang Li, Taiji Yamazoe, Ben Z. Stanger, Zhenyi Su, Maoting Chen, Adam J. Bass, Wei Gu, Anil K. Rustgi, Jessica C. Leung, Anna M. Chiarella, Shoji Natsugoe, Hiroshi Nakagawa, Samuel Pan, Qiaosi Tang, J. Alan Diehl
Publikováno v:
Genes Dev
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide and evolves often to lung metastasis. P53R175H (homologous to Trp53R172H in mice) is a common hot spot mutation. How metastasis is regulated by p53R175H in ESCC rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33807ec0bf0ee5cfec8bcbefa93fc57e
https://europepmc.org/articles/PMC8015716/
https://europepmc.org/articles/PMC8015716/
Autor:
Manabu Muto, Masataka Shimonosono, Takaaki Arigami, Amanda B. Muir, Masaki Mori, Takashi Kijima, Yuta Kasagi, Shinya Ohashi, Andres J. Klein-Szanto, Prasanna M. Chandramouleeswaran, Narayan G. Avadhani, Itaru Omoto, Shoji Natsugoe, Gregory G. Ginsberg, Seiji Naganuma, Veronique Giroux, Varun Sahu, Yoshiaki Shinden, Osamu Kikuchi, Devraj Basu, J. Alan Diehl, Yasuto Uchikado, Koji Tanaka, Yoshiaki Kita, Yuichiro Doki, Adam J. Bass, Ken Sasaki, Hiroshi Nakagawa, Anil K. Rustgi, Kelly A. Whelan, Takeo Hara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thre
IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Autor:
Margaret C. Dunagin, Anil K. Rustgi, Qi Long, E. Paul Wileyto, David A. Frank, Andres J. Klein-Szanto, Varun Sahu, Todd J. Waldron, Sarah R. Walker, Edmund Qiao, Arjun Raj, Adam J. Bass, Kwok-Kin Wong, J. Alan Diehl, Shinya Ohashi, Kiichiro Baba, Qiaosi Tang, Devraj Basu, Zachary T. Giaccone, Eric W. Lin, Monica Soni, Tatiana A. Karakasheva
Publikováno v:
Cancer Research. 78:4957-4970
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an essential co
Autor:
Priya Chatterji, Veronique Giroux, E. Paul Wileyto, Anil K. Rustgi, Kathryn E. Hamilton, Ben Rhoades, Christopher J. Lengner, Julien Stephan, Andres J. Klein-Szanto
Publikováno v:
Stem Cell Reports
Summary Two principal stem cell pools orchestrate the rapid cell turnover in the intestinal epithelium. Rapidly cycling Lgr5+ stem cells are intercalated between the Paneth cells at the crypt base (CBCs) and injury-resistant reserve stem cells reside
Autor:
Timothy Ito, Andres J. Klein-Szanto, Jinfei Xu, Joseph R. Testa, David L. Wiest, Suraj Peri, Eleonora Sementino, Zemin Liu, Yinfei Tan, Kathy Q. Cai, Jianming Pei
Publikováno v:
Oncotarget
// Yinfei Tan 1, * , Eleonora Sementino 1, * , Jinfei Xu 1 , Jianming Pei 1 , Zemin Liu 1 , Timothy K. Ito 1 , Kathy Q. Cai 2 , Suraj Peri 3 , Andres J.P. Klein-Szanto 1, 2 , David L. Wiest 4 , Joseph R. Testa 1 1 Cancer Biology Program, Fox Chase Ca
Autor:
Jennifer R. Pyle, V. Craig Jordan, Andres J. Klein-Szanto, Helen Kim, Joan S. Lewis-Wambi, Chris Wambi, Roshani R. Patel
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-3 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction Estrogen deprivation using aromatase inhibitors is one of the standard treatments for postmenopausal women with estrogen receptor (ER)-positive breast cancer. However, one of the consequences of prolonged estrogen suppression is acquired
Autor:
Jeffrey J Headd, Kathy N. Williams, Jacqueline B Plesset, Ashley A. Lento, Rosemarie Mick, Andres J. Klein-Szanto, Priya Chatterji, Rei Mizuno, Anil K. Rustgi, Sarah F. Andres, Kathryn E. Hamilton
Publikováno v:
Carcinogenesis
The RNA-binding protein insulin-like growth factor 2 mRNA binding protein 1 (IMP1) is overexpressed in colorectal cancer (CRC); however, evidence for a direct role for IMP1 in CRC metastasis is lacking. IMP1 is regulated by let-7 microRNA, which bind
Autor:
Priya Chatterji, Shun Liang, Premal Shah, Kathryn E. Hamilton, Anil K. Rustgi, Philip Hicks, Christopher J. Lengner, Amanda T. Mah, Jason R. Pitarresi, H. R. Sagara Wijeratne, Laurianne Van Landeghem, Andres J. Klein-Szanto, Brian D. Gregory, Lauren Simon, Sarah F. Andres, Blair B. Madison, Shawn W. Foley, Rei Mizuno
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c9891451436aca7a5c710d79a14e7b
https://europepmc.org/articles/PMC6075153/
https://europepmc.org/articles/PMC6075153/