Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Amit Deorukhkar"'
Autor:
Carolina J. Garcia Garcia, Yanqing Huang, Natividad R. Fuentes, Madeleine C. Turner, Maria E. Monberg, Daniel Lin, Nicholas D. Nguyen, Tara N. Fujimoto, Jun Zhao, Jaewon J. Lee, Vincent Bernard, Meifang Yu, Abagail M. Delahoussaye, Iancarlos Jimenez Sacarello, Emily G. Caggiano, Jae L. Phan, Amit Deorukhkar, Jessica M. Molkentine, Dieter Saur, Anirban Maitra, Cullen M. Taniguchi
Publikováno v:
Gastroenterology. 162:2018-2031
Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic, immunosuppressive stroma that contributes to its resistance to immune checkpoint blockade therapies. The hypoxia-inducible factors (HIFs) mediate the cellular response to hypoxia, but their role
Autor:
Helen Piwnica-Worms, Cullen M. Taniguchi, Anirban Maitra, Sonal Gupta, Meifang Yu, Amit Deorukhkar, Marimar de la Cruz Bonilla, Yanqing Huang, Charles V. Kingsley, Laura Baseler, Daniel Lin, Lauren E. Colbert, Eugene J. Koay, Tara N. Fujimoto, Gabriel O. Sawakuchi, Jessica M. Molkentine, Peter K. Cabeceiras, Ramesh C. Tailor
Publikováno v:
Cancer Res
When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and
Autor:
Nicholas D. Nguyen, Jason B. Fleming, Meifang Yu, Eugene J. Koay, Ya'an Kang, F. Anthony San Lucas, Sonal Gupta, Haoqiang Ying, Daniel Lin, Albert C. Koong, Cullen M. Taniguchi, Anirban Maitra, Jessica M. Molkentine, Tara N. Fujimoto, Joseph M. Herman, Conrad J. Fernandes, Amit Deorukhkar, Yanqing Huang
Pancreatic ductal adenocarcinoma (PDAC) requires mitochondrial oxidative phosphorylation (OXPHOS) to fuel its growth; however, broadly inhibiting this pathway might also disrupt essential mitochondrial functions in normal tissues. PDAC cells exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3babfceaa2914d8d295a54c5f9366df
https://europepmc.org/articles/PMC6777817/
https://europepmc.org/articles/PMC6777817/
Autor:
Bhanu Prasad Venkatesulu, Ramesh C. Tailor, John S. Bomalaski, Xiaolin Li, Pankaj Singh, Amit Deorukhkar, Sunil Krishnan
Publikováno v:
Mol Cancer Ther
Distinct metabolic vulnerabilities of cancer cells compared with normal cells can potentially be exploited for therapeutic targeting. Deficiency of argininosuccinate synthetase-1 (ASS1) in pancreatic cancers creates auxotrophy for the semiessential a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192ca1c746f222d34e88fe0fbaf50cfe
https://europepmc.org/articles/PMC6891156/
https://europepmc.org/articles/PMC6891156/
Autor:
Carolina J. Garcia Garcia, James M. Tour, Wai Kin Chan, Aaron J. Grossberg, Tara N. Fujimoto, Philip L. Lorenzi, Robert Dantzer, Daniel Lin, Thomas D. Horvath, Jessica M. Molkentine, Cullen M. Taniguchi, Kathy A. Mason, Marimar de la Cruz Bonilla, Errol L. G. Samuel, Helen Piwnica-Worms, Amit Deorukhkar
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Unresectable pancreatic cancer is almost universally lethal because chemotherapy and radiation cannot completely stop the growth of the cancer. The major problem with using radiation to approximate surgery in unresectable disease is that the radiatio
Autor:
Cemile Koca, Sushovan Guha, Ajaikumar B. Kunnumakkara, Sanjit Dey, Amit Deorukhkar, Zhimin Tong, Sunil Krishnan, Parmeswaran Diagaradjane, Bharat B. Aggarwal, Juri G. Gelovani, Bokyung Sung, Jayaraj Ravindran
Publikováno v:
International Journal of Cancer. 131:E292-E303
Agents that can potentiate the efficacy of standard chemotherapy against pancreatic cancer are of great interest. Because of their low cost and safety, patients commonly use a variety of dietary supplements, although evidence of their efficacy is oft
Autor:
Bharat B. Aggarwal, Sanjit Dey, Sushovan Guha, Zhimin Tong, Parmeswaran Diagaradjane, Juri G. Gelovani, Vivek R. Yadav, Cemile Koca, Jayaraj Ravindran, Bokyung Sung, Sunil Krishnan, Ajaikumar B. Kunnumakkara, Amit Deorukhkar
Publikováno v:
Cancer Research. 70:8695-8705
Pancreatic cancers generally respond poorly to chemotherapy, prompting a need to identify agents that could sensitize tumors to treatment. In this study, we investigated the response of human pancreatic cells to γ-tocotrienol (γ-T3), a novel, unsat
Autor:
Ajaikumar B, Kunnumakkara, Parmeswaran, Diagaradjane, Preetha, Anand, Kuzhuvelil B, Harikumar, Harikumar B, Kuzhuvelil, Amit, Deorukhkar, Juri, Gelovani, Sushovan, Guha, Sunil, Krishnan, Bharat B, Aggarwal
Publikováno v:
International Journal of Cancer. 125:2187-2197
Because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (CRC) is ineffective. Whether curcumin (a component of turmeric) can potentiate the effect
Autor:
Parmeswaran Diagaradjane, Amit Deorukhkar, Ajaikumar B. Kunnumakkara, Sushovan Guha, Shujun Shentu, Bharat B. Aggarwal, Sunil Krishnan
Publikováno v:
Clinical Cancer Research. 14:2128-2136
Purpose: How colorectal cancer develops resistance to γ-radiation is not fully understood, but the transcription factor nuclear factor-κB (NF-κB) and NF-κB–regulated gene products have been proposed as mediators. Because curcumin, a component o
Publikováno v:
Research in Microbiology. 158:399-404
A bacterial strain producing a novel prodigiosin analogue 2,2′-[3-methoxy-1′amyl-5′-methyl-4-(1″-pyrryl)] dipyrrylmethene (MAMPDM) possessing potent cytotoxic activity towards cancer cells was isolated and identified. The bacterial cells were