Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alexey M. Petrov"'
Publikováno v:
Free Radical Biology and Medicine. 174:121-134
Inflammatory reactions induce changes in the neuromuscular system. The mechanisms underlying this link are unclear. Besides cytokines and reactive oxygen species (ROS), production of an antiviral oxysterol 25-hydroxycholesterol (25HC) by immune cells
Publikováno v:
Neurotherapeutics
Cholesterol and 24-hydroxycholesterol are the most abundant brain sterols and represent the substrate and product, respectively, of cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. CYP46A1 controls cholesterol elimination and turnover in the br
Publikováno v:
Brain research. 1795
We investigated the effects of catecholamines, adrenaline and noradrenaline, as well as β-adrenoceptor (AR) modulators on a resting membrane potential at the junctional and extrajunctional regions of mouse fast-twitch Levator auris longus muscle. Th
Publikováno v:
FASEB J
Efavirenz (EFV) is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is the major brain cholesterol hydroxylase. Previously, we discovered that EFV activates CYP46A1 and improves behavioral performance in 5XFAD mice, an Alzheimer’s disease model
Publikováno v:
Neuroscience. 399:135-145
Hydrogen peroxide (H2O2) is one of the reactive oxygen species (ROS), endogenously produced during metabolism, which acts as a second messenger. In skeletal muscles, hypoxia- or hyperthermia-induced increase in H2O2 might affect synaptic transmission
Autor:
Irina A. Pikuleva, Nicole El-Darzi, Ahab Alnemri, Tung Dao, Ying Song, Alexey M. Petrov, Natalia Mast, Joshua L. Dunaief, Aicha Saadane
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2368-2382 (2018)
Apolipoprotein E (APOE) is a component of lipid-transporting particles and a recognition ligand for receptors, which bind these particles. The APOE isoform ε2 is a risk factor for age-related macular degeneration; nevertheless, APOE absence in human
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: 2-Hydroxypropyl-β-cyclodextrin (HPCD) is an FDA approved vehicle for drug delivery and an efficient cholesterol-lowering agent. HPCD was proposed to lower tissue cholesterol via multiple mechanisms including those mediated by
Autor:
Nicole, El-Darzi, Natalia, Mast, Alexey M, Petrov, Tung, Dao, Artem A, Astafev, Aicha, Saadane, Erin, Prendergast, Emmy, Schwarz, Ilya, Bederman, Irina A, Pikuleva
Publikováno v:
Cell Mol Life Sci
Apolipoprotein D (APOD) is an atypical apolipoprotein with unknown significance for retinal structure and function. Conversely, apolipoprotein E (APOE) is a typical apolipoprotein with established roles in retinal cholesterol transport. Herein, we im
Autor:
Aicha Saadane, Irina A. Pikuleva, Alexey M. Petrov, Natalia Mast, Artem A. Astafev, Nicole El-Darzi
Publikováno v:
Biomolecules
Volume 9
Issue 12
Volume 9
Issue 12
In mammalian retina, cholesterol excess is mainly metabolized to oxysterols by cytochromes P450 27A1 (CYP27A1) and 46A1 (CYP46A1) or removed on lipoprotein particles containing apolipoprotein E (APOE). In contrast, esterification by sterol-O-acyltran
Publikováno v:
Cellular signalling. 67
Oxidation of membrane cholesterol is a hallmark of many pathological conditions, including cardiovascular diseases. Cholesterol could be oxidized in a result of free radical and enzymatic reactions. Here, we studied the effect of cholesterol oxidatio