Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Hua Zhang"'
Autor:
Minghong Jian, Xudong Sun, Guorong Cheng, Hua Zhang, Xiaotong Li, Fengrui Song, Zhiqiang Liu, Zhenxin Wang
Publikováno v:
Journal of Natural Products. 85:2424-2432
Because of the abnormal upregulation of matrix metalloproteinase (MMP) activities in tumors, MMP inhibitors (MMPIs) are validated anticancer drug candidates. We identified several MMPIs including mangiferin as an MMP-9 inhibitor with a half maximal i
Autor:
Shuai Shao, Yan-Lin Chen, Lin-Juan Du, Yuan Liu, Hong Zhu, Lu-Jun Zhou, Ting Liu, Wen-Zhen Lin, Fei Yu, Xiao-Xin Ma, Xue-Rui Shi, Xiao-Qian Meng, Yan Liu, Yong-Li Wang, Lan Bai, Xiao-Hua Zhang, Feng Jia, Sheng-Zhong Duan
Publikováno v:
Journal of Cardiovascular Translational Research. 15:816-827
Microglia/macrophage activation plays an essential role in Ischemic stroke (IS). Nuclear receptor corepressor 1 (NCoR1) has been identified as a vital regulator in macrophages. The present study aims to explore the functions of macrophage NCoR1 in IS
Publikováno v:
International journal of pharmaceutics. 630
Infliximab (INF) is intravenously used for the clinical treatment of rheumatoid arthritis. However, it can cause serious side effects, which are mainly associated with systemic exposure and high doses. Here, we developed a modified hydrophobic ion-pa
Autor:
Spencer K. Tumbale, R. Holland Cheng, Elizabeth S. Ingham, Wei-Lun Tang, Sarah M. Tam, Bo Wu, Alexander D. Borowsky, Katherine W. Ferrara, Mo Baikoghli, Marina Nura Raie, Brett Z. Fite, Josquin Foiret, Azadeh Kheirolomoom, Lisa M. Mahakian, Hua Zhang, Kenneth Lau
Publikováno v:
J Control Release
Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. However, systemic delivery of R848 is poorly tolerated because of its poor solubility in water and systemic immune activation. In
Autor:
Hua Zhang, Ying Xu, Hailin Yang, Yongping Mu, Dingqi Zhang, Ping Liu, Zhun Xiao, Jiamei Chen, Li-jun Zhang, Gaofeng Chen, Wei Liu
Publikováno v:
Pharmaceutical Biology, Vol 58, Iss 1, Pp 1238-1252 (2020)
Pharmaceutical Biology
article-version (VoR) Version of Record
Pharmaceutical Biology
article-version (VoR) Version of Record
Context Xiayuxue decoction (XYXD), a traditional Chinese medicine, is used for treating liver disease. However, the potential active constituents and mechanisms are still unclear. Objective To explore the main active fraction extracts, active ingredi
Autor:
Hua Zhang, Kejun Cheng, Xiuxiu Dai, Zhou Lifen, Xiaoya Wang, Mengtian Xu, Zhiyong Liu, Yong Sun, Yaokun Xiong
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 93
Background Mosla chinensis Maxim. cv. Jiangxiangru (JXR), a traditional Chinese medicine, commonly used for the therapy of cold, fever, diarrhea, digestive disorders, and other diseases. Inflammatory bowel disease (IBD) is a chronic disorder of the h
Autor:
Tian Luo, Zhao Li, Xue-Mei Deng, Kan Jiang, Dan Liu, Hong-Hua Zhang, Tao Shi, Lin-Yi Liu, Huai-Xiu Wen, Qi-En Li, Zhen Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 60:116705
Isoquinoline alkaloid displays significant anti-gastric cancer effects due to its unique structure, which is attracting more and more attention for the development of anti-gastric cancer drugs. In this study, we explore the active components against
Autor:
Elizabeth S. Ingham, Marina Nura-Raie, Katherine W. Ferrara, Sarah M. Tam, Azadeh Kheirolomoom, Jamal S. Lewis, Hamilton Kakwere, Asaf Ilovitsh, Riley Allen, Brett Z. Fite, Spencer K. Tumbale, Bo Wu, Hua Zhang, Cheng Liu
Publikováno v:
Adv Healthc Mater
Advanced healthcare materials, vol 10, iss 10
Advanced healthcare materials, vol 10, iss 10
Resiquimod is an immunopotent toll-like receptor 7/8 agonist with antitumor activity. Despite being potent against skin cancers, it is poorly tolerated systemically due to toxicity. Integrating resiquimod into nanoparticles presents an avenue to circ
Autor:
Song Jiali, Juan Zhang, Ke Han, Cheng-Shi Jiang, Qianqian Zhang, Yuying Zhang, Li Jiacheng, Hua Zhang, Jin-Tian Huang
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(17)
In this study, a series of compounds with 1,2,4-oxadiazole core was designed and synthesized for the optimization of JC01, an anti-inflammatory hit identified from our in-house compound library using NF-κB pathway luciferase assay and NO production
Autor:
Wei Yin, Panpan Sun, Hua Zhang, Ajab Khan, Kuohai Fan, Hongquan Li, Xiaozhong Zheng, Jianhua Guo, Yaogui Sun, Na Sun
BackgroundPRRSV and PCV2 co-infection is very common in swine industry which results in huge economic losses worldwide. Although vaccination is used to prevent viral diseases, immunosuppression induced by PRRSV and PCV2 leads to vaccine failure. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e69afaf66e5435dd35a0855d0c92fd
https://doi.org/10.21203/rs.3.rs-25795/v1
https://doi.org/10.21203/rs.3.rs-25795/v1