Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ye Zheng"'
Autor:
Sagar P. Bapat, Caroline Whitty, Cody T. Mowery, Yuqiong Liang, Arum Yoo, Zewen Jiang, Michael C. Peters, Ling-juan Zhang, Ian Vogel, Carmen Zhou, Vinh Q. Nguyen, Zhongmei Li, Christina Chang, Wandi S. Zhu, Annette T. Hastie, Helen He, Xin Ren, Wenli Qiu, Sarah G. Gayer, Chang Liu, Eun Jung Choi, Marlys Fassett, Jarish N. Cohen, Jamie L. Sturgill, Laura E. Crotty Alexander, Jae Myoung Suh, Christopher Liddle, Annette R. Atkins, Ruth T. Yu, Michael Downes, Sihao Liu, Barbara S. Nikolajczyk, In-Kyu Lee, Emma Guttman-Yassky, K. Mark Ansel, Prescott G. Woodruff, John V. Fahy, Dean Sheppard, Richard L. Gallo, Chun Jimmie Ye, Ronald M. Evans, Ye Zheng, Alexander Marson
Publikováno v:
Nature, vol 604, iss 7905
Decades of work have elucidated cytokine signalling and transcriptional pathways that control T cell differentiation and haveled the way to targeted biologic therapies that are effective in a range of autoimmune, allergic and inflammatory diseases. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2437f4952bbe1f222362a7c14dbf448
https://escholarship.org/uc/item/2bv4q0k3
https://escholarship.org/uc/item/2bv4q0k3
Autor:
S. Jeson Sangaralingham, Kanupriya Whig, Satyamaheshwar Peddibhotla, R. Jason Kirby, Hampton E. Sessions, Patrick R. Maloney, Paul M. Hershberger, Heather Mose-Yates, Becky L. Hood, Stefan Vasile, Shuchong Pan, Ye Zheng, Siobhan Malany, John C. Burnett
Publikováno v:
Proc Natl Acad Sci U S A
The particulate guanylyl cyclase A receptor (GC-A), via activation by its endogenous ligands atrial natriuretic peptide (ANP) and b-type natriuretic peptide (BNP), possesses beneficial biological properties such as blood pressure regulation, natriure
Autor:
Yuqiong Liang, Michael Downes, Theodore M. Kamenecka, Ruth T. Yu, Annette R. Atkins, Ye Zheng, Ronald M. Evans, Thomas P. Burris, Chin-San Loo, Laura A. Solt, Sagar P Bapat, Mathias Leblanc, Han Cho, Christina L. Chang, Xuan Zhao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Th17 cells are a subset of T cells that produce interleukin 17 and other proinflammatory cytokines. They are involved in the development of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Previous studies illustr
Autor:
Mathias Leblanc, Christopher Liddle, Ronald M. Evans, Annette R. Atkins, Ruth T. Yu, Jae Myoung Suh, Yuqiong Liang, Ye Zheng, Michael Downes, Sihao Liu, Carmen Zhou, Sungsoon Fang, Yang Zhang, Albert Cheng, Sagar P. Bapat
Publikováno v:
Nature. 528:137-141
Age-associated insulin resistance (IR) and obesity-associated IR are two physiologically distinct forms of adult-onset diabetes. While macrophage-driven inflammation is a core driver of obesity-associated IR, the underlying mechanisms of the obesity-
Autor:
Ronald M. Evans, Annette R. Atkins, Ye Zheng, Michael Downes, Weiwei Fan, Christopher Liddle, Ruth T. Yu, Nanhai He, Brian Henriquez
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Regulatory T cells (Tregs) play a critical role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses that may cause collateral damage to the host. Unlike other CD4+ T cells, Tregs have a distinct
Autor:
Lauren A. Mack, Christopher Liddle, Sigal Gery, Zhengshan Chen, Qi Cao, Henry Yang, Xianping Shi, Xuan Zhao, Haibo Sun, De-Chen Lin, Qi Chen, Jonathan W. Said, Serhan Alkan, Jing-Wen Bai, Ruishu Deng, Ling Wa Chong, Markus Müschen, Michael Downes, Ronald M. Evans, Jian-Jun Xie, Han Cho, Ruth T. Yu, Annette R. Atkins, Ye Zheng, Quan Zhen Li, H. Phillip Koeffler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 47
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec83e67eefb01b297a9051e42544974f
https://escholarship.org/uc/item/6wn972xv
https://escholarship.org/uc/item/6wn972xv
Autor:
Alexander Y. Rudensky, Katherine A. Forbush, Ye Zheng, Steven Z. Josefowicz, Xiao P. Peng, Ashutosh Chaudhry
Publikováno v:
Nature. 463:808-812
Immune homeostasis is dependent on tight control over the size of a population of regulatory T (T(reg)) cells capable of suppressing over-exuberant immune responses. The T(reg) cell subset is comprised of cells that commit to the T(reg) lineage by up
Autor:
Marc A. Gavin, Steven Z. Josefowicz, Alexander Y. Rudensky, Arnold Kas, Tin-Tin Chu, Ye Zheng
Publikováno v:
Nature. 445:936-940
Transcription factor Foxp3 (forkhead box P3), restricted in its expression to a specialized regulatory CD4+ T-cell subset (T(R)) with a dedicated suppressor function, controls T(R) lineage development. In humans and mice, Foxp3 deficiency results in
A long-standing hypothesis posits that a G protein-coupled signaling pathway mediates β-adrenergic nervous system functions, including learning and memory. Here we report that memory retrieval (reactivation) induces the activation of β1-adrenergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d3169371c4d99f872579a0488d3de3
https://europepmc.org/articles/PMC4394255/
https://europepmc.org/articles/PMC4394255/
Autor:
Christina Chang, Jeniffer B. Hernandez, John Le Lay, Klaus H. Kaestner, Marc Montminy, Mathias Leblanc, Ye Zheng, David Grimm
Publikováno v:
Nature communications
Following their activation in response to inflammatory signals, innate immune cells secrete T cell polarizing cytokines that promote the differentiation of naïve CD4 T cells into T helper (Th) cell subsets. Amongst these, Th17 cells play a prominent