Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Tamura A"'
Autor:
Toshiaki Ito, Atsuki Osada, Masami Ohta, Kana Yokota, Akira Nishiyama, Yuichi Niikura, Tomohiko Tamura, Yoichi Sekita, Tohru Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Sexual reproduction involves the creation of sex-dependent gametes, oocytes and sperm. In mammals, sexually dimorphic differentiation commences in the primordial germ cells (PGCs) in embryonic gonads; PGCs in ovaries and testes differentiate into mei
Autor:
Shinya Taguchi, Kengo Azushima, Takahiro Yamaji, Shingo Urate, Toru Suzuki, Eriko Abe, Shohei Tanaka, Shunichiro Tsukamoto, Daisuke Kamimura, Sho Kinguchi, Akio Yamashita, Hiromichi Wakui, Kouichi Tamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Tumor necrosis factor (TNF)-α is a potent mediator of inflammation and is involved in the pathophysiology of chronic kidney disease (CKD). However, the effects of TNF-α inhibition on the progression of kidney fibrosis have not been fully elucidated
Autor:
Atsushi Tamura, Koya Suzuki, Kotone Kawamura, Jun Kasamatsu, Tong Zong, Kazuyoshi Kawakami, Hideki Yamamoto, Yuki Kitai, Hiroshi Kiyonari, Tomomitsu Miyasaka, Daiki Tanno, Sachiko Tsukita, Keiko Ishii, Aki Shiraishi, Hiromasa Tanno, Ko Sato, Ikumi Matsumoto, Anna Miyahara, Takafumi Kagesawa, Akiho Oniyama, Aya Umeki, Emi Kanno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Cryptococcus deneoformans is an opportunistic fungal pathogen that infects the lungs via airborne transmission and frequently causes fatal meningoencephalitis. Claudins (Cldns), a family of proteins with 27 members found in mammals, form the tight ju
Autor:
Hiroshi Okuda, Ryo Miyamoto, Satoshi Takahashi, Takeshi Kawamura, Juri Ichikawa, Ibuki Harada, Tomohiko Tamura, Akihiko Yokoyama
Publikováno v:
Nature Communications. 13
Chromosomal translocation generates the MLL-AF4 fusion gene, which causes acute leukemia of multiple lineages. MLL-AF4 is a strong oncogenic driver that induces leukemia without additional mutations and is the most common cause of pediatric leukemia.
Autor:
Eriko Abe, Akio Yamashita, Keigo Hirota, Takahiro Yamaji, Kengo Azushima, Shingo Urate, Toru Suzuki, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Tatsuki Uehara, Hiromichi Wakui, Kouichi Tamura, Hidehisa Takahashi
Publikováno v:
Scientific Reports. 12
Kidney fibrosis is a common pathway that leads to chronic kidney disease. Angiotensin II type-1 receptor (AT1R)-associated protein (ATRAP) was originally identified as an AT1R-binding protein. Previously, we reported that systemic knockout of ATRAP e
Autor:
Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C. Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Publikováno v:
Nature Communications. 13
Aging is considered to be accelerated by insulin signaling in lower organisms, but it remained unclear whether this could hold true for mammals. Here we show that mice with skeletal muscle-specific double knockout of Akt1/2, key downstream molecules
Autor:
Eriko Abe, Daisuke Sano, Daisuke Kamimura, Takayuki Yamada, Takahiro Yamaji, Kengo Azushima, Shohei Tanaka, Shunichiro Tsukamoto, Shinya Taguchi, Hiromichi Wakui, Masayuki Nakano, Sho Kinguchi, Akio Yamashita, Toru Suzuki, Tatsuo Hashimoto, Kouichi Tamura, Shingo Urate
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Elevated angiotensin-converting enzyme 2 (ACE2) expression in organs that are potential targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of coronavirus disease 2019 (COVID-19) infection. Previous reports show that ACE2
Autor:
Ryusuke Yoshimi, Tadatsugu Taniguchi, Hideyuki Yanai, Shuichi Suzuki, Akira Nishiyama, Hideaki Nakajima, Tadashi Yamamoto, Shuichi Ito, Kappei Tsukahara, Yohei Kirino, Noriko Tagata, Go R. Sato, Kenichi Nishimura, Tatsuma Ban, Hiroe Hihara, Masako Kikuchi, Akio Manabe, Masashi Ito, Kentaro Yoshimatsu, Yoshiko Matsumoto, Kayo Harita, Tomohiko Tamura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
The transcription factor IRF5 has been implicated as a therapeutic target for the autoimmune disease systemic lupus erythematosus (SLE). However, IRF5 activation status during the disease course and the effects of IRF5 inhibition after disease onset
Autor:
Daisuke Kurotaki, Kenta Kikuchi, Kairong Cui, Wataru Kawase, Keita Saeki, Junpei Fukumoto, Akira Nishiyama, Kisaburo Nagamune, Keji Zhao, Keiko Ozato, Pedro P. Rocha, Tomohiko Tamura
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Classical dendritic cells (cDCs) are essential for immune responses and differentiate from hematopoietic stem cells via intermediate progenitors, such as monocyte−DC progenitors (MDPs) and common DC progenitors (CDPs). Upon infection, cDCs are acti
Autor:
Masato, Uemura, Tamio, Furuse, Ikuko, Yamada, Tomoko, Kushida, Takaya, Abe, Keiko, Imai, Soichi, Nagao, Moeko, Kudoh, Katsuhiko, Yoshizawa, Masaru, Tamura, Hiroshi, Kiyonari, Shigeharu, Wakana, Shinji, Hirano
Publikováno v:
Scientific Reports. 12
Protocadherin 9 (Pcdh9) is a member of the cadherin superfamily and is uniquely expressed in the vestibular and limbic systems; however, its physiological role remains unclear. Here, we studied the expression of Pcdh9 in the limbic system and phenoty