Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Patrick Trojer"'
Autor:
Chisato Henry, Jennifer Busby, Charlie Hatton, Barbara M. Bryant, Brian Egan, Chih-Chi Yuan, Theresa K. Kelly, Madeleine Lisa Craske, Marie Classon, Gulfem D. Guler, Suchit Jhunjhunwala, Paul Labhart, Tobias M. Maile, Charles Tindell, David Arnott, Feng Zhao, Patrick Trojer
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 11, p e0166438 (2016)
PLoS ONE, Vol 11, Iss 11, p e0166438 (2016)
Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require mo
Autor:
Patrick Trojer
Publikováno v:
Epigenetics for Drug Discovery ISBN: 9781849738828
Post-translational modifications of histones are recognised as important determinants of chromatin architecture and are well appreciated as an instrument to exert control over cellular processes that require access to DNA such as transcription, repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::204799079072ac5d0065206f5f76f253
https://doi.org/10.1039/9781782628484-00127
https://doi.org/10.1039/9781782628484-00127
Autor:
Adrian M. Senderowicz, Neal D. Shore, Patrick Trojer, Claudia Lebedinsky, Arif Hussain, Emmanuel S. Antonarakis, Mary-Ellen Taplin, Bill Bradley
Publikováno v:
Journal of Clinical Oncology. 36:TPS398-TPS398
TPS398 Background: EZH2 is frequently mutated and overexpressed in human cancer. High levels of expression are correlated with disease stage, aggressiveness, and poor outcome in patients with prostate cancer (Varambally, 2002). EZH2 inhibition restor
Autor:
Barry M. Zee, Christodoulos A. Floudas, Patrick Trojer, Meghan B. Peterson, James Smadbeck, Christina Ji-Young Lee, Aashna Mago, Athanassios Giannis, Shivani Garapaty, Benjamin A. Garcia
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e95535 (2014)
PLoS ONE, Vol 9, Iss 2, p e90095 (2014)
PLoS ONE, Vol 9, Iss 4, p e95535 (2014)
PLoS ONE, Vol 9, Iss 2, p e90095 (2014)
Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA-protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhanc
Autor:
Srividya Balachander, Kaylyn E. Williamson, Patrick Trojer, Barbara M. Bryant, Shruti Apte, Jennifer Busby, Charlie Hatton, Shilpi Arora
Publikováno v:
Blood. 128:5672-5672
Post-translational modifications of the histone proteins play a key role in regulating processes that require access to DNA. Specifically, methylation of lysine 27 on histone 3 (H3K27) is intimately linked with transcriptional repression. EZH2, a his
Autor:
Danny Reinberg, Patrick Trojer
Publikováno v:
Nature Chemical Biology. 4:332-334
Lysine methyltransferases are well-known regulators of transcription through their methylation of histone lysine residues. Now high-throughput peptide arrays reveal non-histone substrates of G9a/KMT3C, which was previously known as a euchromatic hist
Autor:
Eric Y. Chan, Barry M. Zee, Peter A. DiMaggio, Benjamin A. Garcia, Gary LeRoy, Yibin Kang, Sherry Liu, Barbara M. Bryant, M Andres Blanco, Patrick Trojer, Ian Z. Flaniken
Publikováno v:
Epigenetics & Chromatin
Background An integral component of cancer biology is the understanding of molecular properties uniquely distinguishing one cancer type from another. One class of such properties is histone post-translational modifications (PTMs). Many histone PTMs a
Autor:
Astrid Spannhoff, Ingo Bauer, Wolfgang Sippl, Manfred Jung, Rene Meier, Ralf Heinke, Patrick Trojer
Publikováno v:
ChemMedChem. 4(1)
Lysine and arginine methyltransferases participate in the posttranslational modification of histones and regulate key cellular functions. Protein arginine methyltransferase 1 (PRMT1) has been identified as an essential component of mixed lineage leuk
Autor:
Gerald Brosch, Manfred Jung, Ralf Heinke, Wolfgang Sippl, Eric Metzger, Roland Prof. Schule, Patrick Trojer, Ingo Bauer, Astrid Spannhoff, Ronald Gust
Publikováno v:
Journal of medicinal chemistry. 50(10)
Lysine and arginine methyltransferases participate in the post-translational modification of histones and regulate key cellular functions. So far only one arginine methyltransferase inhibitor discovered by random screening was available. We present t
Autor:
Roland Schüle, Rospita Machmur, Patrick Trojer, Wolfgang Sippl, Ralf Heinke, Manfred Jung, Wolfgang Hanefeld, Astrid Spannhoff, Gerald Brosch, Ingo Bauer
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
Via virtual screening we identified a thioglycolic amide as an arginine methyltransferase (PRMT) inhibitor and tested it and related compounds against the fungal PRMT RmtA and human PRMT1. Compound RM65 was the most potent druglike inhibitor (IC(50)-