Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hariharan Easwaran"'
Autor:
Marcin J. Domagalski, Wen Jiang, Michael Smith, Li Ding, Michael Schnaubelt, Oxana Paklina, Gilbert S. Omenn, Magdalena Derejska, Karin D. Rodland, Johanna Gardner, Saravana M. Dhanasekaran, Pamela Grady, Pushpa Hariharan, David Mallery, Jesse Francis, Maciej Wiznerowicz, Eunkyung An, Nancy Roche, Ralph H. Hruban, Samuel H. Payne, Chen Huang, Olga Potapova, Gad Getz, Zhiao Shi, Shuai Guo, Oliver F. Bathe, Stacey Gabriel, Sandra Cottingham, Hui Zhang, Daniel Cui Zhou, Maureen Dyer, Houxiang Zhu, James Suh, Shuang Cai, Christopher R. Kinsinger, Felipe da Veiga Leprevost, Steven Chen, Chelsea J. Newton, Amanda G. Paulovich, Steven A. Carr, Melissa Borucki, Sandra Cerda, Troy Shelton, D. R. Mani, Tara Hiltke, Lijun Chen, Benjamin Haibe-Kains, Jiang Long, Ratna R. Thangudu, Arul M. Chinnaiyan, Mathangi Thiagarajan, Negin Vatanian, Peter Ronning, Thomas L. Bauer, Ki Sung Um, Christina Ayad, Seungyeul Yoo, Mitual Amin, Ruiyang Liu, Alicia Francis, Nikolay Gabrovski, Eric E. Schadt, Zhen Zhang, Alexey I. Nesvizhskii, Hariharan Easwaran, Huan Chen, Tao Liu, Elizabeth R. Duffy, Liwei Cao, Joshua M. Wang, Michael H.A. Roehrl, Antonio Colaprico, Ana I. Robles, Emily S. Boja, Rita Jui-Hsien Lu, Rodrigo Vargas Eguez, Yize Li, Jennifer M. Koziak, Wenke Liu, Weiming Yang, Arvind Singh Mer, Dana R. Valley, Sailaja Mareedu, Song Cao, Scott D. Jewell, William Bocik, Shilpi Singh, Yongchao Dou, Matthew A. Wyczalkowski, David Fenyö, Galen Hostetter, Liqun Qi, Wenyi Wang, Yvonne Shutack, Shirley Tsang, Karen A. Ketchum, Charles A. Goldthwaite, Katherine A. Hoadley, Richard D. Smith, Karsten Krug, Yuxing Liao, Nadezhda V. Terekhanova, Henry Rodriguez, Barbara Hindenach, Matthew J. Ellis, Yingwei Hu, Pei Wang, Daniel C. Rohrer, Sara R. Savage, Grace Zhao, Ludmila Danilova, Yige Wu, Parham Minoo, Jennifer M. Eschbacher, Nathan Edwards, T. Mamie Lih, Simina M. Boca, George D. Wilson, Alexey Shabunin, Bing Zhang, Michael A. Gillette, Brian J. Druker, David J. Clark, Jianbo Pan, Katarzyna Kusnierz, David Chesla, Ronald Matteotti, Corbin D. Jones, Michael J. Birrer, Lori J. Sokoll, Qing Kay Li, Mehdi Mesri, Peter B. McGarvey, Chet Birger, Barbara Pruetz, Daniel W. Chan, Bo Wen, Nicollette Maunganidze, Jasmine Huang
Publikováno v:
Cell
Summary Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40a7dc2c7c1ea5d3684e8a5dd266c0d
https://europepmc.org/articles/PMC8654574/
https://europepmc.org/articles/PMC8654574/
Autor:
Miguel A. Peinado, Xiangqian Kong, Shinji Maegawa, Nicholas C. Zachos, Yong Tao, Yuba R. Bhandari, Byunghak Kang, Elana J. Fertig, Jean Pierre J. Issa, Yi Cai, Wenbing Xie, Stephen B. Baylin, Daniel A. Petkovich, Izaskun Mallona, Genevieve Stein-O’Brien, Ray Whay Chiu Yen, Yuezheng Zhang, Hariharan Easwaran, Nita Ahuja, Stephen M. Brown, Cynthia A. Zahnow, Xiaojian Shao, Jai Thakor, Himani Vaidya, Zhihao Lu, Julie In
Publikováno v:
Cancer Cell
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
We addressed the precursor role of aging-like spontaneous promoter DNA hypermethylation in initiating tumorigenesis. Using mouse colon-derived organoids, we show that promoter hypermethylation spontaneously arises in cells mimicking the human aging-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726d795dd960279d63396d9c2016bc01
https://europepmc.org/articles/PMC6636642/
https://europepmc.org/articles/PMC6636642/
Autor:
Jiang Qian, Dylan Z. Kelley, Daria A. Gaykalova, Alexander V. Favorov, Emily Flam, Heather C. Wick, Luciane T. Kagohara, Elana J. Fertig, Hariharan Easwaran, Genevieve Stein-O’Brien, Ludmila Danilova
Publikováno v:
Briefings in Functional Genomics
Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in even individual malignant cells. Epigenetic changes are critical mediators of these functional changes that drive and maintain the malignant phenotype. Changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d0b13ef7dbd8bde9336bce36fde098
Autor:
Roisin M. Connolly, Angela A. Guzzetta, Stephen B. Baylin, Vered Stearns, Nancy E. Davidson, Cynthia A. Zahnow, Dennis J. Slamon, Nilofer S. Azad, Rajita Vatapalli, Huili Li, Jianjun Luo, Nita Ahuja, Katherine B. Chiappinelli, Michael J. Topper, Peter A. Jones, Drew M. Pardoll, Ray Whay Chiu Yen, Hariharan Easwaran
Publikováno v:
Oncotarget
// Huili Li 1,* , Katherine B. Chiappinelli 1,* , Angela A. Guzzetta 1,* , Hariharan Easwaran 1 , Ray-Whay Chiu Yen 1 , Rajita Vatapalli 1 , Michael J. Topper 1 , Jianjun Luo 1 , Roisin M. Connolly 1,2 , Nilofer S. Azad 1 , Vered Stearns 1,2 , Drew M
Publikováno v:
BMC Medical Genomics
Background Bivalent chromatin refers to overlapping regions containing activating histone H3 Lys4 trimethylation (H3K4me3) and inactivating H3K27me3 marks. Existence of such bivalent marks on the same nucleosome has only recently been suggested. Prev
Autor:
Heather M. O'Hagan, Yi Cai, Stephen B. Baylin, Yang W. Zhang, Eriko G. Clements, Christina E. DeStefano Shields, Leander Van Neste, Wei Wang, Robert A. Casero, Hariharan Easwaran, Stella S. Lee, Subhojit Sen, Cynthia L. Sears
Publikováno v:
Cancer Cell. 20(5):606-619
SummaryCancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin. DNMT1 becomes p
Autor:
Hetty E. Carraway, James G. Herman, Steven A. Belinsky, Elizabeth A. Griffiths, Yi Zhang, Stephen B. Baylin, Hariharan Easwaran, Tza-Huei Wang, Vasudev J. Bailey
Publikováno v:
Genome Research. 19:1455-1461
DNA methylation contributes to carcinogenesis by silencing key tumor suppressor genes. Here we report an ultrasensitive and reliable nanotechnology assay, MS-qFRET, for detection and quantification of DNA methylation. Bisulfite-modified DNA is subjec
Autor:
Byunghak Kang, Jean Pierre J. Issa, Julie In, Stephen B. Baylin, Nicholas C. Zachos, David L. Huso, Hariharan Easwaran, Shinji Maegawa
Publikováno v:
Cancer Research. 76:4273-4273
Herein, we report a model for how BRAF mutations, in contrast to KRAS mutations, specifically associate with and induce, in mouse colon organoids without a microenvironment, the phenotype of human sporadic right-sided colon adenocarcinomas (COAD). Th
Publikováno v:
Cancer Research. 76:B18-B18
Chronic inflammation has been shown to play a significant role in mediating early epigenetic changes that contribute to the development of cancer. Prolonged exposure to inflammatory stimuli such as cigarette smoke causes genetic and epigenetic altera
Autor:
Hetty E. Carraway, Hariharan Easwaran, Yi-Ping Ho, Yi Zhang, James G. Herman, Malcolm V. Brock, Vasudev J. Bailey, Kristen Pelosky, Stephen B. Baylin, Tza-Huei Wang, Brian P. Keeley
Publikováno v:
Bailey, V J, Keeley, B P, Zhang, Y, Ho, Y-P, Easwaran, H, Brock, M V, Pelosky, K L, Carraway, H E, Baylin, S B, Herman, J G & Wang, T-H 2010, ' Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection ', ChemBioChem, vol. 11, no. 1, pp. 71-4 . https://doi.org/10.1002/cbic.200900630
DNA methylation is an epigenetic modification that occurs at 5′ cytosine in CpG dinucleotides and is observed in high frequency in the transcription promoter regions of tumor-suppressor genes.[1,2] Such changes account for the loss of function of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc7ec297c506f6cf63b0cd77667a6e1
https://europepmc.org/articles/PMC2981340/
https://europepmc.org/articles/PMC2981340/