Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
Autor:
Priya Chatterji, Uma M. Sachdeva, Helen Remotti, Rei Mizuno, Kensuke Suzuki, Anil K. Rustgi, Michael P. Verzi, Sepideh Besharati, Yasunori Masuike, Wenping Sun, Sarah F. Andres, Andres J. Klein-Szanto
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status that is preserved even in metastatic tumors. However, the molecular mechanisms underlying CRC differentiation remain to be elucidated. Herein, we unravel a
Autor:
Kwok-K Wong, Maureen E. Murphy, Jason R. Pitarresi, Mirazul Islam, Gizem Efe, Tatiana A. Karakasheva, Jianhua Hu, Andres J. Klein-Szanto, Jinyang Li, Taiji Yamazoe, Ben Z. Stanger, Zhenyi Su, Maoting Chen, Adam J. Bass, Wei Gu, Anil K. Rustgi, Jessica C. Leung, Anna M. Chiarella, Shoji Natsugoe, Hiroshi Nakagawa, Samuel Pan, Qiaosi Tang, J. Alan Diehl
Publikováno v:
Genes Dev
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide and evolves often to lung metastasis. P53R175H (homologous to Trp53R172H in mice) is a common hot spot mutation. How metastasis is regulated by p53R175H in ESCC rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33807ec0bf0ee5cfec8bcbefa93fc57e
https://europepmc.org/articles/PMC8015716/
https://europepmc.org/articles/PMC8015716/
Autor:
Jeffrey J Headd, Kathy N. Williams, Jacqueline B Plesset, Ashley A. Lento, Rosemarie Mick, Andres J. Klein-Szanto, Priya Chatterji, Rei Mizuno, Anil K. Rustgi, Sarah F. Andres, Kathryn E. Hamilton
Publikováno v:
Carcinogenesis
The RNA-binding protein insulin-like growth factor 2 mRNA binding protein 1 (IMP1) is overexpressed in colorectal cancer (CRC); however, evidence for a direct role for IMP1 in CRC metastasis is lacking. IMP1 is regulated by let-7 microRNA, which bind
Autor:
Kathleen Schuck, N. Volkan Adsay, Anil K. Rustgi, Albert B. Reynolds, Lauren Simon, Karin Feldmann, Dieter Saur, Wilko Weichert, Matthias Wirth, Anna Melissa Schlitter, Basil Bakir, Burcin Pehlivanoglu, Andres J. Klein-Szanto, Andrew D. Rhim, Leticia Moreira, Günter Schneider, Bahar Memis, Maximilian Reichert, Kensuke Suzuki, Ravikanth Maddipati, Jason R. Pitarresi, Mark Kriegsmann
Publikováno v:
Developmental Cell
Summary The regulation of metastatic organotropism in pancreatic ductal a denocarcinoma (PDAC) remains poorly understood. We demonstrate, using multiple mouse models, that liver and lung metastatic organotropism is dependent upon p120catenin ( p120ct
Publikováno v:
Molecular Carcinogenesis. 54:1122-1131
PACE4 (PCSK6) is a proprotein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated whe
Autor:
Meenhard Herlyn, Christie M. Gutierrez, Gabrielle S. Wong, J. Alan Diehl, Carmen Z. Michaylira, Rachel Hammond, Ju Seog Lee, Phyllis A. Gimotty, Andres J. Klein-Szanto, Sang Bae Kim, Anil K. Rustgi, Hiroshi Nakagawa, Charles G. Miller
Publikováno v:
Cancer Research. 70:5281-5292
Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. H
Autor:
Kiranmai Gumireddy, George Coukos, le Sage C, Reuven Agami, Dionyssios Katsaros, Mariette Schrier, David A. Egan, Phyllis A. Gimotty, Andres J. Klein-Szanto, Nair S, Remco Nagel, Guanghua Huang, Lin Zhang, Puré E, Qihong Huang, Anping Li
Publikováno v:
Nature Cell Biology. 10:202-210
MicroRNAs (miRNAs) are single-stranded, noncoding RNAs that are important in many biological processes1,2. Although the oncogenic and tumour-suppressive functions of several miRNAs have been characterized, the role of miRNAs in mediating tumour metas
Autor:
Fangxian Sun, Aleister J. Saunders, Phyllis A. Gimotty, Andres J. Klein-Szanto, Qihong Huang, Kiranmai Gumireddy, Peter G. Schultz, Jonathan M. Gibbins
Publikováno v:
Proceedings of the National Academy of Sciences. 104:6696-6701
Here, we report the identification of a metastasis promoting factor by a forward genetic screen in mice. A retroviral cDNA library was introduced into the nonmetastatic cancer cell line 168FARN, which was then orthotopically transplanted into mouse m
Autor:
Traci Lifsted, Max Williams, Andres J. Klein-Szanto, Kent W. Hunter, Thomas Le Voyer, Kenneth H. Buetow, William J. Muller
Publikováno v:
International Journal of Cancer. 77:640-644
Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that h