Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Colin P.N. Dinney"'
Autor:
Colin P.N. Dinney, Sharada Mokkapati, Vikram M. Narayan, Neema Navai, Bogdan Czerniak, Tiewei Cheng, Ganiraju C. Manyam, Sima P. Porten, Woonyoung Choi, Jonathan Melquist, Amy Lim, Shanna Pretzsch, Matthew F. Wszolek, David J. McConkey, Beat Roth, Isuru Jayaratna, Bradley M. Broom
Publikováno v:
Molecular cancer research : MCR. 18(6)
Little is known regarding the subclone evolution process in advanced bladder cancer, particularly with respect to the genomic alterations that lead to the development of metastatic lesions. In this project, we identify gene expression signatures asso
Autor:
Ann M. Killary, Meng Chen, George L. Delclos, Colin P.N. Dinney, Jian Gu, Michelle A.T. Hildebrandt, H. Barton Grossman, Xifeng Wu, Zhen Fan, Robert M. Chamberlain
Publikováno v:
Carcinogenesis. 31:1387-1391
The phosphoinositide-3 kinase (PI3K)–AKT– mammalian target of rapamycin (mTOR) pathway is an important cellular pathway controlling cell growth, tumorigenesis, cell invasion and drug response. We hypothesized that genetic variations in the PI3K
Autor:
Liana Adam, Lauren Marquis, Woonyoung Choi, David J. McConkey, Michael B. Williams, Frances M Martin, Ashish M. Kamat, Arlene O. Siefker-Radtke, Jay B. Shah, Aditi Das, Robert S. Svatek, Colin P.N. Dinney
Publikováno v:
Cancer and Metastasis Reviews. 28:335-344
Epithelial-to-mesenchymal transition (EMT) is a process that plays essential roles in development and wound healing that is characterized by loss of homotypic adhesion and cell polarity and increased invasion and migration. At the molecular level, EM
Autor:
Colin P.N. Dinney, Peter C. Black
Publikováno v:
Cancer metastasis reviews. 26(3-4)
In the majority of cases, death from bladder cancer results from metastatic disease. Understanding the closely linked mechanisms of invasion, metastasis and angiogenesis in bladder cancer has allowed us to develop new therapeutic strategies that harb
Autor:
H. Barton Grossman, Yunfei Wang, Jun Liu, A. Karim Kader, Xifeng Wu, Colin P.N. Dinney, Jie Lin, Lina Shao, Jian Gu
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(9)
Purpose: Matrix metalloproteinases (MMP) promote tumor invasion and alter microenvironment. MMP levels are elevated in bladder cancer patients correlating with more advanced stage. We tested whether polymorphisms in MMP genes modify the risk of bladd
Autor:
Robert A. Stephenson, Nelson G. Ordóñez, Isaiah J. Fidler, Kazuo Gohji, Colin P.N. Dinney, Jerald J. Killion
Publikováno v:
Journal of the National Cancer Institute. 84(12)
Background Understanding the mechanism of prostate cancer metastasis is essential to the design of a more effective therapy. An effective therapy for this disease will depend on the development of a clinically relevant in vivo model. Purpose We descr