Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael, Wagner"'
Autor:
Leonhard Lennertz, Norbert Kathmann, Katharina Bey, Michael Wagner, Stephan Heinzel, Anja Riesel, Ulrich Ettinger, Christian Kaufmann, Julia Klawohn, Inga Meyhöfer, Rosa Grützmann
Publikováno v:
European archives of psychiatry and clinical neuroscience 269(2), 235-243 (2018). doi:10.1007/s00406-018-0899-x
Patients with obsessive-compulsive disorder (OCD) show dysfunctions of the fronto-striatal circuitry, which imply corresponding oculomotor deficits including smooth pursuit eye movements (SPEM). However, evidence for a deficit in SPEM is inconclusive
Autor:
Gail Davies, Max Lam, Sarah E. Harris, Joey W. Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloe Fawns-Ritchie, David C. M. Liewald, Judith A. Okely, Ari V. Ahola-Olli, Catriona L. K. Barnes, Lars Bertram, Joshua C. Bis, Katherine E. Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E. Gustavson, Caroline Hayward, Edith Hofer, M. Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A. Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A. Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A. Smith, Albert V. Smith, Natalie Terzikhan, Anbupalam Thalamuthu, Stella Trompet, Sven J. van der Lee, Erin B. Ware, B. Gwen Windham, Margaret J. Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A. Andreassen, Nicola J. Armstrong, Amelia A. Assareh, John R. Attia, Deborah Attix, Dimitrios Avramopoulos, David A. Bennett, Anne C. Böhmer, Patricia A. Boyle, Henry Brodaty, Harry Campbell, Tyrone D. Cannon, Elizabeth T. Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R. Cox, Anders M. Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G. Eriksson, Evangelos Evangelou, Jessica D. Faul, Ian Ford, Nelson A. Freimer, He Gao, Ina Giegling, Nathan A. Gillespie, Scott D. Gordon, Rebecca F. Gottesman, Michael E. Griswold, Vilmundur Gudnason, Tamara B. Harris, Annette M. Hartmann, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G. Holliday, Peter K. Joshi, Mika Kähönen, Sharon L. R. Kardia, Ida Karlsson, Luca Kleineidam, David S. Knopman, Nicole A. Kochan, Bettina Konte, John B. Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Christina M. Lill, Tian Liu, Marisa Koini, Edythe London, Will T. Longstreth, Oscar L. Lopez, Anu Loukola, Tobias Luck, Astri J. Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G. Martin, Grant W. Montgomery, Alison D. Murray, Anna C. Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A. Poldrack, Bruce M. Psaty, Simone Reppermund, Steffi G. Riedel-Heller, Richard J. Rose, Jerome I. Rotter, Panos Roussos, Suvi P. Rovio, Yasaman Saba, Fred W. Sabb, Perminder S. Sachdev, Claudia L. Satizabal, Matthias Schmid, Rodney J. Scott, Matthew A. Scult, Jeannette Simino, P. Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C. Stefanis, David J. Stott, Richard E. Straub, Kjetil Sundet, Adele M. Taylor, Kent D. Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N. Voineskos, Jaakko Kaprio, Michael Wagner, Holger Wagner, Leonie Weinhold, K. Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab H. H. Adams, Dan E. Arking, Robert M. Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L. De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L. Fitzpatrick, Michael Gill, David C. Glahn, Sara Hägg, Narelle K. Hansell, Ahmad R. Hariri, M. Kamran Ikram, J. Wouter Jukema, Eero Vuoksimaa, Matthew C. Keller, William S. Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L. Pedersen, Neil Pendleton, David J. Porteous, Katri Räikkönen, Olli T. Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W. Schofield, Peter R. Schofield, John M. Starr, Vidar M. Steen, Julian N. Trollor, Steven T. Turner, Cornelia M. Van Duijn, Arno Villringer, Daniel R. Weinberger, David R. Weir, James F. Wilson, Anil Malhotra, Andrew M. McIntosh, Catharine R. Gale, Sudha Seshadri, Thomas H. Mosley, Jan Bressler, Todd Lencz, Ian J. Deary
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications 9(1), 2098 (2018). doi:10.1038/s41467-018-04362-x
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.2098. ⟨10.1038/s41467-018-04362-x⟩
Davies, G, Lam, M, Harris, S E, Trampush, J W, Luciano, M, Hill, W D, Hagenaars, S P, Ritchie, S J, Marioni, R E, Fawns-ritchie, C, Liewald, D C M, Okely, J A, Ahola-olli, A V, Barnes, C L K, Bertram, L, Bis, J C, Burdick, K E, Christoforou, A, Derosse, P, Djurovic, S, Espeseth, T, Giakoumaki, S, Giddaluru, S, Gustavson, D E, Hayward, C, Hofer, E, Ikram, M A, Karlsson, R, Knowles, E, Lahti, J, Leber, M, Li, S, Mather, K A, Melle, I, Morris, D, Oldmeadow, C, Palviainen, T, Payton, A, Pazoki, R, Petrovic, K, Reynolds, C A, Sargurupremraj, M, Scholz, M, Smith, J A, Smith, A V, Terzikhan, N, Thalamuthu, A, Trompet, S, Van Der Lee, S J, Ware, E B, Windham, B G, Wright, M J, Yang, J, Yu, J, Ames, D, Amin, N, Amouyel, P, Andreassen, O A, Armstrong, N J, Assareh, A A, Attia, J R, Attix, D, Avramopoulos, D, Bennett, D A, Böhmer, A C, Boyle, P A, Brodaty, H, Campbell, H, Cannon, T D, Cirulli, E T, Congdon, E, Conley, E D, Corley, J, Cox, S R, Dale, A M, Dehghan, A, Dick, D, Dickinson, D, Eriksson, J G, Evangelou, E, Faul, J D, Ford, I, Freimer, N A, Gao, H, Giegling, I, Gillespie, N A, Gordon, S D, Gottesman, R F, Griswold, M E, Gudnason, V, Harris, T B, Hartmann, A M, Hatzimanolis, A, Heiss, G, Holliday, E G, Joshi, P K, Kähönen, M, Kardia, S L R, Karlsson, I, Kleineidam, L, Knopman, D S, Kochan, N A, Konte, B, Kwok, J B, Le Hellard, S, Lee, T, Lehtimäki, T, Li, S, Liu, T, Koini, M, London, E, Longstreth, W T, Lopez, O L, Loukola, A, Luck, T, Lundervold, A J, Lundquist, A, Lyytikäinen, L, Martin, N G, Montgomery, G W, Murray, A D, Need, A C, Noordam, R, Nyberg, L, Ollier, W, Papenberg, G, Pattie, A, Polasek, O, Poldrack, R A, Psaty, B M, Reppermund, S, Riedel-heller, S G, Rose, R J, Rotter, J I, Roussos, P, Rovio, S P, Saba, Y, Sabb, F W, Sachdev, P S, Satizabal, C L, Schmid, M, Scott, R J, Scult, M A, Simino, J, Slagboom, P E, Smyrnis, N, Soumaré, A, Stefanis, N C, Stott, D J, Straub, R E, Sundet, K, Taylor, A M, Taylor, K D, Tzoulaki, I, Tzourio, C, Uitterlinden, A, Vitart, V, Voineskos, A N, Kaprio, J, Wagner, M, Wagner, H, Weinhold, L, Wen, K H, Widen, E, Yang, Q, Zhao, W, Adams, H H H, Arking, D E, Bilder, R M, Bitsios, P, Boerwinkle, E, Chiba-falek, O, Corvin, A, De Jager, P L, Debette, S, Donohoe, G, Elliott, P, Fitzpatrick, A L, Gill, M, Glahn, D C, Hägg, S, Hansell, N K, Hariri, A R, Ikram, M K, Jukema, J W, Vuoksimaa, E, Keller, M C, Kremen, W S, Launer, L, Lindenberger, U, Palotie, A, Pedersen, N L, Pendleton, N, Porteous, D J, Räikkönen, K, Raitakari, O T, Ramirez, A, Reinvang, I, Rudan, I, Dan Rujescu, Schmidt, R, Schmidt, H, Schofield, P W, Schofield, P R, Starr, J M, Steen, V M, Trollor, J N, Turner, S T, Van Duijn, C M, Villringer, A, Weinberger, D R, Weir, D R, Wilson, J F, Malhotra, A, Mcintosh, A M, Gale, C R, Seshadri, S, Mosley, T H, Bressler, J, Lencz, T & Deary, I J 2018, ' Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ', Nature Communications, vol. 9, no. 1, 2098 . https://doi.org/10.1038/s41467-018-04362-x
Nature Communications, 9
Nature Communications, 9:2098. Nature Publishing Group
Davies, G, Lam, M, Harris, S E, Trampush, J W, Luciano, M, Hill, W D, Hagenaars, S P, Ritchie, S J, Marioni, R E, Fawns-Ritchie, C, Liewald, D C M, Okely, J A, Ahola-Olli, A V, Barnes, C L K, Bertram, L, Bis, J C, Burdick, K E, Christoforou, A, DeRosse, P, Djurovic, S, Espeseth, T, Giakoumaki, S, Giddaluru, S, Gustavson, D E, Hayward, C, Hofer, E, Ikram, M A, Karlsson, R, Knowles, E, Lahti, J, Leber, M, Li, S, Mather, K A, Melle, I, Morris, D, Oldmeadow, C, Palviainen, T, Payton, A, Pazoki, R, Petrovic, K, Reynolds, C A, Sargurupremraj, M, Scholz, M, Smith, J A, Smith, A V, Terzikhan, N, Thalamuthu, A, Trompet, S, van der Lee, S J, Ware, E B, Windham, B G, Wright, M J, Yang, J, Yu, J, Ames, D, Amin, N, Amouyel, P, Andreassen, O A, Armstrong, N J, Assareh, A A, Attia, J R, Attix, D, Avramopoulos, D, Bennett, D A, Böhmer, A C, Boyle, P A, Brodaty, H, Campbell, H, Cannon, T D, Cirulli, E T, Congdon, E, Conley, E D, Corley, J, Cox, S R, Dale, A M, Dehghan, A, Dick, D, Dickinson, D, Eriksson, J G, Evangelou, E, Faul, J D, Ford, I, Freimer, N A, Gao, H, Giegling, I, Gillespie, N A, Gordon, S D, Gottesman, R F, Griswold, M E, Gudnason, V, Harris, T B, Hartmann, A M, Hatzimanolis, A, Heiss, G, Holliday, E G, Joshi, P K, Kähönen, M, Kardia, S L R, Karlsson, I, Kleineidam, L, Knopman, D S, Kochan, N A, Konte, B, Kwok, J B, Le Hellard, S, Lee, T, Lehtimäki, T, Li, S-C, Liu, T, Koini, M, London, E, Longstreth, W T, Lopez, O L, Loukola, A, Luck, T, Lundervold, A J, Lundquist, A, Lyytikäinen, L-P, Martin, N G, Montgomery, G W, Murray, A D, Need, A C, Noordam, R, Nyberg, L, Ollier, W, Papenberg, G, Pattie, A, Polasek, O, Poldrack, R A, Psaty, B M, Reppermund, S, Riedel-Heller, S G, Rose, R J, Rotter, J I, Roussos, P, Rovio, S P, Saba, Y, Sabb, F W, Sachdev, P S, Satizabal, C L, Schmid, M, Scott, R J, Scult, M A, Simino, J, Slagboom, P E, Smyrnis, N, Soumaré, A, Stefanis, N C, Stott, D J, Straub, R E, Sundet, K, Taylor, A M, Taylor, K D, Tzoulaki, I, Tzourio, C, Uitterlinden, A, Vitart, V, Voineskos, A N, Kaprio, J, Wagner, M, Wagner, H, Weinhold, L, Wen, K H, Widen, E, Yang, Q, Zhao, W, Adams, H H H, Arking, D E, Bilder, R M, Bitsios, P, Boerwinkle, E, Chiba-Falek, O, Corvin, A, De Jager, P L, Debette, S, Donohoe, G, Elliott, P, Fitzpatrick, A L, Gill, M, Glahn, D C, Hägg, S, Hansell, N K, Hariri, A R, Ikram, M K, Jukema, J W, Vuoksimaa, E, Keller, M C, Kremen, W S, Launer, L, Lindenberger, U, Palotie, A, Pedersen, N L, Pendleton, N, Porteous, D J, Räikkönen, K, Raitakari, O T, Ramirez, A, Reinvang, I, Rudan, I, Dan Rujescu, Schmidt, R, Schmidt, H, Schofield, P W, Starr, J M, Steen, V M, Trollor, J N, Turner, S T, Van Duijn, C M, Villringer, A, Weinberger, D R, Weir, D R, Wilson, J F, Malhotra, A, McIntosh, A M, Gale, C R, Seshadri, S, Mosley, T H, Bressler, J, Lencz, T & Deary, I J 2018, ' Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ', Nature Communications, vol. 9, no. 1, pp. 2098 . https://doi.org/10.1038/s41467-018-04362-x
Nature Communications 9(1), 2098 (2018). doi:10.1038/s41467-018-04362-x
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.2098. ⟨10.1038/s41467-018-04362-x⟩
Davies, G, Lam, M, Harris, S E, Trampush, J W, Luciano, M, Hill, W D, Hagenaars, S P, Ritchie, S J, Marioni, R E, Fawns-ritchie, C, Liewald, D C M, Okely, J A, Ahola-olli, A V, Barnes, C L K, Bertram, L, Bis, J C, Burdick, K E, Christoforou, A, Derosse, P, Djurovic, S, Espeseth, T, Giakoumaki, S, Giddaluru, S, Gustavson, D E, Hayward, C, Hofer, E, Ikram, M A, Karlsson, R, Knowles, E, Lahti, J, Leber, M, Li, S, Mather, K A, Melle, I, Morris, D, Oldmeadow, C, Palviainen, T, Payton, A, Pazoki, R, Petrovic, K, Reynolds, C A, Sargurupremraj, M, Scholz, M, Smith, J A, Smith, A V, Terzikhan, N, Thalamuthu, A, Trompet, S, Van Der Lee, S J, Ware, E B, Windham, B G, Wright, M J, Yang, J, Yu, J, Ames, D, Amin, N, Amouyel, P, Andreassen, O A, Armstrong, N J, Assareh, A A, Attia, J R, Attix, D, Avramopoulos, D, Bennett, D A, Böhmer, A C, Boyle, P A, Brodaty, H, Campbell, H, Cannon, T D, Cirulli, E T, Congdon, E, Conley, E D, Corley, J, Cox, S R, Dale, A M, Dehghan, A, Dick, D, Dickinson, D, Eriksson, J G, Evangelou, E, Faul, J D, Ford, I, Freimer, N A, Gao, H, Giegling, I, Gillespie, N A, Gordon, S D, Gottesman, R F, Griswold, M E, Gudnason, V, Harris, T B, Hartmann, A M, Hatzimanolis, A, Heiss, G, Holliday, E G, Joshi, P K, Kähönen, M, Kardia, S L R, Karlsson, I, Kleineidam, L, Knopman, D S, Kochan, N A, Konte, B, Kwok, J B, Le Hellard, S, Lee, T, Lehtimäki, T, Li, S, Liu, T, Koini, M, London, E, Longstreth, W T, Lopez, O L, Loukola, A, Luck, T, Lundervold, A J, Lundquist, A, Lyytikäinen, L, Martin, N G, Montgomery, G W, Murray, A D, Need, A C, Noordam, R, Nyberg, L, Ollier, W, Papenberg, G, Pattie, A, Polasek, O, Poldrack, R A, Psaty, B M, Reppermund, S, Riedel-heller, S G, Rose, R J, Rotter, J I, Roussos, P, Rovio, S P, Saba, Y, Sabb, F W, Sachdev, P S, Satizabal, C L, Schmid, M, Scott, R J, Scult, M A, Simino, J, Slagboom, P E, Smyrnis, N, Soumaré, A, Stefanis, N C, Stott, D J, Straub, R E, Sundet, K, Taylor, A M, Taylor, K D, Tzoulaki, I, Tzourio, C, Uitterlinden, A, Vitart, V, Voineskos, A N, Kaprio, J, Wagner, M, Wagner, H, Weinhold, L, Wen, K H, Widen, E, Yang, Q, Zhao, W, Adams, H H H, Arking, D E, Bilder, R M, Bitsios, P, Boerwinkle, E, Chiba-falek, O, Corvin, A, De Jager, P L, Debette, S, Donohoe, G, Elliott, P, Fitzpatrick, A L, Gill, M, Glahn, D C, Hägg, S, Hansell, N K, Hariri, A R, Ikram, M K, Jukema, J W, Vuoksimaa, E, Keller, M C, Kremen, W S, Launer, L, Lindenberger, U, Palotie, A, Pedersen, N L, Pendleton, N, Porteous, D J, Räikkönen, K, Raitakari, O T, Ramirez, A, Reinvang, I, Rudan, I, Dan Rujescu, Schmidt, R, Schmidt, H, Schofield, P W, Schofield, P R, Starr, J M, Steen, V M, Trollor, J N, Turner, S T, Van Duijn, C M, Villringer, A, Weinberger, D R, Weir, D R, Wilson, J F, Malhotra, A, Mcintosh, A M, Gale, C R, Seshadri, S, Mosley, T H, Bressler, J, Lencz, T & Deary, I J 2018, ' Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ', Nature Communications, vol. 9, no. 1, 2098 . https://doi.org/10.1038/s41467-018-04362-x
Nature Communications, 9
Nature Communications, 9:2098. Nature Publishing Group
Davies, G, Lam, M, Harris, S E, Trampush, J W, Luciano, M, Hill, W D, Hagenaars, S P, Ritchie, S J, Marioni, R E, Fawns-Ritchie, C, Liewald, D C M, Okely, J A, Ahola-Olli, A V, Barnes, C L K, Bertram, L, Bis, J C, Burdick, K E, Christoforou, A, DeRosse, P, Djurovic, S, Espeseth, T, Giakoumaki, S, Giddaluru, S, Gustavson, D E, Hayward, C, Hofer, E, Ikram, M A, Karlsson, R, Knowles, E, Lahti, J, Leber, M, Li, S, Mather, K A, Melle, I, Morris, D, Oldmeadow, C, Palviainen, T, Payton, A, Pazoki, R, Petrovic, K, Reynolds, C A, Sargurupremraj, M, Scholz, M, Smith, J A, Smith, A V, Terzikhan, N, Thalamuthu, A, Trompet, S, van der Lee, S J, Ware, E B, Windham, B G, Wright, M J, Yang, J, Yu, J, Ames, D, Amin, N, Amouyel, P, Andreassen, O A, Armstrong, N J, Assareh, A A, Attia, J R, Attix, D, Avramopoulos, D, Bennett, D A, Böhmer, A C, Boyle, P A, Brodaty, H, Campbell, H, Cannon, T D, Cirulli, E T, Congdon, E, Conley, E D, Corley, J, Cox, S R, Dale, A M, Dehghan, A, Dick, D, Dickinson, D, Eriksson, J G, Evangelou, E, Faul, J D, Ford, I, Freimer, N A, Gao, H, Giegling, I, Gillespie, N A, Gordon, S D, Gottesman, R F, Griswold, M E, Gudnason, V, Harris, T B, Hartmann, A M, Hatzimanolis, A, Heiss, G, Holliday, E G, Joshi, P K, Kähönen, M, Kardia, S L R, Karlsson, I, Kleineidam, L, Knopman, D S, Kochan, N A, Konte, B, Kwok, J B, Le Hellard, S, Lee, T, Lehtimäki, T, Li, S-C, Liu, T, Koini, M, London, E, Longstreth, W T, Lopez, O L, Loukola, A, Luck, T, Lundervold, A J, Lundquist, A, Lyytikäinen, L-P, Martin, N G, Montgomery, G W, Murray, A D, Need, A C, Noordam, R, Nyberg, L, Ollier, W, Papenberg, G, Pattie, A, Polasek, O, Poldrack, R A, Psaty, B M, Reppermund, S, Riedel-Heller, S G, Rose, R J, Rotter, J I, Roussos, P, Rovio, S P, Saba, Y, Sabb, F W, Sachdev, P S, Satizabal, C L, Schmid, M, Scott, R J, Scult, M A, Simino, J, Slagboom, P E, Smyrnis, N, Soumaré, A, Stefanis, N C, Stott, D J, Straub, R E, Sundet, K, Taylor, A M, Taylor, K D, Tzoulaki, I, Tzourio, C, Uitterlinden, A, Vitart, V, Voineskos, A N, Kaprio, J, Wagner, M, Wagner, H, Weinhold, L, Wen, K H, Widen, E, Yang, Q, Zhao, W, Adams, H H H, Arking, D E, Bilder, R M, Bitsios, P, Boerwinkle, E, Chiba-Falek, O, Corvin, A, De Jager, P L, Debette, S, Donohoe, G, Elliott, P, Fitzpatrick, A L, Gill, M, Glahn, D C, Hägg, S, Hansell, N K, Hariri, A R, Ikram, M K, Jukema, J W, Vuoksimaa, E, Keller, M C, Kremen, W S, Launer, L, Lindenberger, U, Palotie, A, Pedersen, N L, Pendleton, N, Porteous, D J, Räikkönen, K, Raitakari, O T, Ramirez, A, Reinvang, I, Rudan, I, Dan Rujescu, Schmidt, R, Schmidt, H, Schofield, P W, Starr, J M, Steen, V M, Trollor, J N, Turner, S T, Van Duijn, C M, Villringer, A, Weinberger, D R, Weir, D R, Wilson, J F, Malhotra, A, McIntosh, A M, Gale, C R, Seshadri, S, Mosley, T H, Bressler, J, Lencz, T & Deary, I J 2018, ' Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ', Nature Communications, vol. 9, no. 1, pp. 2098 . https://doi.org/10.1038/s41467-018-04362-x
Publisher's version (útgefin grein)
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, an
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, an
Autor:
Laura M. Thornton, Paul Lichtenstein, Verneri Anttila, Diego Albani, Josep Antoni Ramos-Quiroga, Roger A.H. Adan, Monika Schlögelhofer, Stephen Sanders, Enrique Castelao, Klaus Berger, Nina Dalkner, Urs Heilbronner, Engilbert Sigurdsson, Pablo Mir, Fuquan Zhang, James T.R. Walters, Patrick F. Sullivan, Fragiskos Gonidakis, F. Kyle Satterstrom, Sara Marsal, Per Hoffmann, Amy Perry, Valentina Ciullo, Beate Herpertz-Dahlmann, Catharina Lavebratt, Kieran C. Murphy, Tammy Hedderly, Hyun Ju Hong, Evald Saemundsen, Sascha B. Fischer, Hailiang Huang, Andrew D. Grotzinger, Nienke Vulink, Murray B. Stein, Mark A. Frye, Laura J. Scott, David Curtis, Todd Lencz, Janiece E. DeSocio, Richard A. Belliveau, Eduard Vieta, Andrea Dietrich, Wade H. Berrettini, Kenneth S. Kendler, Marquis P. Vawter, Paul S. Nestadt, Michael E. Talkowski, Manuel Mattheisen, Ingrid Agartz, Elisa Docampo, Bernhard T. Baune, Stefan Ehrlich, Jolanta Lissowska, Felecia Cerrato, Terje Nærland, Robin M. Murray, Jennifer Reichert, Annette M. Hartmann, Hannelore Ehrenreich, Howard J. Edenberg, Katherine A. Halmi, Qingqin S. Li, Peristera Paschou, Marie Bækvad-Hansen, Esther Walton, Alessio Maria Monteleone, Ted Reichborn-Kjennerud, Frank Bellivier, Jungeun Song, D. Blake Woodside, Young Shin Kim, Jochen Seitz, Jacques Pantel, Palmiero Monteleone, Erika L. Nurmi, Rodney J. Scott, Kang Sim, Ekaterina A. Khramtsova, Udo Dannlowski, Rolf Adolfsson, Danielle Posthuma, Melissa J. Green, Laura Ibanez-Gomez, Jakob Grove, Elvira Bramon, Gregory L. Hanna, Cynthia M. Bulik, Yiran Guo, Stephan Ripke, Mary M. Robertson, Harald N. Aschauer, Adebayo Anjorin, Joanna Martin, Bertram Müller-Myhsok, Deborah Kaminská, Jose Guzman-Parra, Benedetta Nacmias, Erik G. Jönsson, Jonathan R. I. Coleman, Douglas F. Levinson, Hamdi Mbarek, Gun Peggy Knudsen, Karin Egberts, Mette Nyegaard, Patrik K. E. Magnusson, Mark Adams, Douglas Blackwood, Elisabeth B. Binder, Marcus Ising, Anna R. Docherty, Jim van Os, Nese Direk, Lina Martinsson, Maria Arranz, Christel M. Middeldorp, Stefan Kloiber, Sintia Iole Belangero, Eske M. Derks, Ingrid Melle, Erlend Bøen, Jan Haavik, Federica Piras, Unna N. Danner, Anil K. Malhotra, Gerome Breen, Stephen V. Faraone, Amanda B Zheutlin, Timothy Poterba, Stephan Ruhrmann, Inge Joa, Ulrik Fredrik Malt, Sarah E. Bergen, Federica Tozzi, Lauren A. Weiss, Hana Papezova, Dominic Holland, Elliot S. Gershon, Jaakko Kaprio, Merete Nordentoft, Scott D. Gordon, Christopher Pittenger, Keun-Ah Cheon, Jennifer Jordan, Philip Gorwood, Myrna M. Weissman, Preben Bo Mortensen, Melissa A. Munn-Chernoff, Isobel Heyman, Eun-Young Shin, Christie L. Burton, Katherine Gordon-Smith, Sietske G. Helder, Peter Nagy, Till F. M. Andlauer, Yunpeng Wang, Young Key Kim, Kate Langley, Søren Dalsgaard, Richard Delorme, Torbjørn Elvsåshagen, Bennett L. Leventhal, Giovanni Gambaro, Christos Androutsos, Jennifer Tübing, Marion Roberts, Annelie Nordin Adolfsson, Hakon Hakonarson, Dorothy E. Grice, Vaughan J. Carr, Konstantinos Tziouvas, Stephanie Zerwas, Cathy L. Barr, Michael Conlon O'Donovan, Per Qvist, Beate St Pourcain, Samuel Kuperman, Leila Karhunen, Jack Samuels, Markus M. Nöthen, Martien J H Kas, Alfonso Tortorella, Mikael Landén, Jennifer Crosbie, Marco A. Grados, Joanna M. Biernacka, Paul D. Arnold, Irene A. Malaty, Jurjen J. Luykx, Nicholas Bass, Naomi R. Wray, Catharina A. Hartman, Christina M. Hultman, Michael S. Okun, Brandon Wormley, Michael Bauer, Daniel J. Smith, Ian Jones, Kathryn Roeder, Brien P. Riley, Caroline M. Nievergelt, Katrin Gade, Sarah Kittel-Schneider, Roy H. Perlis, James R. Mitchell, Ziarih Hawi, James Lee, Liz Forty, William E. Bunney, Thomas Damm Als, Catherine Schaefer, Digby Quested, Matteo Cassina, Anna C. Koller, Patrick Turley, Agnes A. Steixner, Anu Raevuori, Assen Jablensky, Peter Holmans, Dong-Ho Song, S. Evelyn Stewart, Jan K. Buitelaar, Fernando S. Goes, Alexander Münchau, Ayman H. Fanous, Nicolas Ramoz, James B. Potash, Monica Gratacos Mayora, Tobias Banaschewski, Céline S. Reinbold, Renata Rizzo, Arianna Di Florio, Lenka Foretova, Gianfranco Spalletta, Aarno Palotie, Eleftheria Zeggini, Lawrence W. Brown, Julie K. O'Toole, Lynn E. DeLisi, Ulrich Schall, Mary Roberson, Barbara J. Coffey, Bryan J. Mowry, Murray J. Cairns, Dan J. Stein, Glyn Lewis, Marta Ribasés, C. Robert Cloninger, Bettina Konte, John B. Vincent, Duncan S. Palmer, Radhika Kandaswamy, Christine Ladd-Acosta, Lars Alfredsson, Frank Visscher, Ulrike Schmidt, Aiden Corvin, Susan L. Santangelo, Brenda W.J.H. Penninx, David J. Porteous, Tetsuya Ando, Arne E. Vaaler, Bru Cormand, Laura Carlberg, Claire Churchhouse, Manfred Stuhrmann, Niamh Mullins, Christine Søholm Hansen, Cathy L. Budman, Hartmut Imgart, Dan E. Arking, James J. McGough, Michael Gill, Christel Depienne, Roland Burghardt, Antonio Julià, Anders M. Dale, Sven Sandin, Katharina Domschke, Maria Grigoroiu-Serbanescu, Susana Jiménez-Murcia, Marianne Giørtz Pedersen, Zsanett Tarnok, Gisli Baldursson, Michele T. Pato, David M. Hougaard, Thorgeir E. Thorgeirsson, Katharina Bey, Kerstin J. Plessen, Margaret A. Richter, Ole A. Andreassen, Claudine Laurent-Levinson, Leonid Padyukov, Jacques Mallet, Daniela Degortes, John R. Kelsoe, Robert D. Levitan, Andreas Reif, Chaim Huyser, Derek W. Morris, Sina Wanderer, William Byerley, Edna Grünblatt, E.J.C. de Geus, Hyejung Won, Josephine Elia, Rudolf Uher, Jay A. Tischfield, Andreas Karwautz, Gustavo Turecki, Pieter J. Hoekstra, Dorret I. Boomsma, Jacob Rosenthal, Daniele Cusi, Michael C. Neale, Sara Mostafavi, Gwyneth Zai, F. Anthony O'Neill, Gary Donohoe, Karola Rehnström, Harry Brandt, Helena Gaspar, Francis J. McMahon, H-Erich Wichmann, Andrew W. Bergen, Giovanni Coppola, Lea K. Davis, Lenka Slachtova, Olav B. Smeland, Erin C. Dunn, Nicholas G. Martin, Allan L. Naarden, Jo Knight, Cristina Sánchez-Mora, Masashi Ikeda, Lorraine Southam, Sandro Sorbi, Barbara Franke, Martin Schalling, Russell Schachar, Yen-Chen Anne Feng, Kirsten R. Müller-Vahl, André Scherag, Zhaozhong Zhu, Eric A. Storch, Páll Magnússon, David Cohen, Olafur O Gudmundsson, Harvey S. Singer, Brian Kelly, Jonas Bybjerg-Grauholm, Blanca Garcia-Delgar, Thomas Hansen, Carmel M. Loughland, Christine Lochner, Stacy Steinberg, Martin Woods, Jorge A. Quiroz, Raquel Rabionet, Alden Y. Huang, Janice M. Fullerton, María Soler Artigas, Hans J. Grabe, Philip Asherson, Margit Burmeister, Alicia R. Martin, Martin A. Kennedy, Janet Treasure, Anders D. Børglum, Eva C. Schulte, Andreas Hartmann, Frans Henskens, Youl-Ri Kim, Jens Treutlein, Joanna Hauser, Manfred M. Fichter, Damiaan Denys, Ann E. Pulver, Kelly L. Klump, Paul Sandor, Michael Wagner, Philippe Courtet, Sandra Van der Auwera, Susanne Lucae, Eystein Stordal, Michel G. Nivard, Maurizio Clementi, Astrid Morer, Philip B. Mitchell, Huda Akil, Edwin H. Cook, Jennifer L. Moran, Donald W. Black, Jeremiah M. Scharf, Jana Strohmaier, Colm McDonald, Meg M.-J. Wang, Richard M. Myers, Stephanie Godard, Pablo V. Gejman, Athanasios Maras, Marcella Rietschel, Nancy G. Buccola, Konstantinos Hatzikotoulas, Dalila Pinto, Jouke-Jan Hottenga, Kari Stefansson, James S. Sutcliffe, Andres Metspalu, Amaia Hervás, Joel Gelernter, Wolfgang Herzog, Paula Rovira, Gunnar Morken, Tara Murphy, Mark Weiser, Vincent Millischer, Frank Dudbridge, Dan Rujescu, Vladimir Bencko, Valdo Ricca, Kimberly Chambert, Guy A. Rouleau, James J. Crowley, Thomas G. Schulze, Toni-Kim Clarke, Triinu Peters, Gudrun Wagner, Daniel A. Geller, Henry R. Kranzler, G. Bragi Walters, Vera Golimbet, Clement C. Zai, Nigel Williams, Andreas Birgegård, Joseph D. Buxbaum, Elliot M. Tucker-Drob, Jerome C. Foo, Tracey L. Petryshen, Daniel P. Howrigan, Hunna J. Watson, Franziska Degenhardt, Peter R. Schofield, Jesper Buchhave Poulsen, Stefan Herms, Johannes Hebebrand, Mario Maj, George Kirov, Fabrizio Piras, Sara McDevitt, James T. McCracken, Carol A. Mathews, Michael John Owen, Peter Falkai, Donald L. Gilbert, Enda M. Byrne, Fernando Fernández-Aranda, Csaba Barta, Stéphane Jamain, Jubao Duan, Dongmei Yu, Danielle C. Cath, Ole Mors, Sigrun Hope, Laramie E. Duncan, Alan R. Sanders, Sang-Yun Oh, Carsten Bøcker Pedersen, Henning Tiemeier, Roseann E. Peterson, Raymond K. Walters, Margarita C T Slof-Op 't Landt, Madeline Alexander, Stephanie Le Hellard, Ina Giegling, Annemarie A. van Elburg, Steven P. Hamilton, Vesna Boraska Perica, Thomas V. Fernandez, Danielle M. Dick, Francesco Bettella, Roel A. Ophoff, Grant W. Montgomery, Gerald Nestadt, Nakao Iwata, Jessica H. Baker, Walter H. Kaye, Jeremy M. Silverman, Mark J. Daly, Robert A. King, Sarah E. Medland, Anastasios Konstantinidis, Robert D. Oades, Samuel H. Zinner, Steven Crawford, Daniel H. Geschwind, Patrick W. L. Leung, Martin Alda, Marie Navratilova, Pak C. Sham, Paul A. Tooney, Tian Ge, Veit Roessner, Martin Preisig, Thomas Werge, Eli A. Stahl, David A. Collier, Stephanie H. Witt, Dermot Walsh, Miquel Casas, Anna Keski-Rahkonen, Jane H. Christensen, Silvia De Rubeis, Giorgio Pistis, Sven Cichon, Bruno Etain, Dominique Campion, O. Joseph Bienvenu, Christian Dina, Manolis Kogevinas, Thomas Espeseth, Benjamin M. Neale, Ditte Demontis, Klaus-Peter Lesch, Marina Mitjans, Tiffany A. Greenwood, Marcos Madruga-Garrido, Sibylle G. Schwab, Oedegaard Ketil Joachim, Hreinn Stefansson, Sara A. Paciga, Monica Forzan, Dieter B. Wildenauer, Lena Backlund, A. Jeremy Willsey, Carlos N. Pato, Nicholas John Craddock, Inge A. Meijer, Sandra K. Loo, Filip Rybakowski, Tracey D. Wade, Scott J. Crow, Bernard Lerer, Valsamma Eapen, Esben Agerbo, Andrew M. McIntosh, Luis Augusto Rohde, Susan L. McElroy, Stephan Zipfel, Peter P. Zandi, Cathryn M. Lewis, Lars Klareskog, Martin Begemann, Phil Lee, Richard Anney, Mark A. Bellgrove, Lisa Jones, Andreas J. Forstner, Agnieszka Słopień, Hilary Coon, Dong Li, Alessandro Serretti, Carsten Horn, Christos Pantelis, Ryan L. Collins, David M. Howard, Lucía Colodro-Conde, Pippa A. Thomson, Martin Hautzinger, Alysa E. Doyle, Julie Hagstrøm, Oliver S. P. Davis, Karen S. Mitchell, Jordan W. Smoller, Michael Strober, John I. Nurnberger, Andrea G. Ludolph, Monika Budde, Anna Maaser, Lambertus Klei, Aribert Rothenberger, Yulia Worbe, Fabian Streit, James L. Kennedy, Barbara E. Stranger, Ashley Dumont, Jianxin Shi, Dale R. Nyholt, Craig Johnson, Jonna Kuntsi, Yun-Joo Koh, Loes M. Olde Loohuis, Robert B. Freedman, Anke Hinney, Susanne Walitza, Enrico Domenici, Margarita Rivera, Sodahm Kook, Erica Greenberg, Tetyana Zayats, Josef Frank, Gary A. Heiman, Andrew McQuillin, Abraham Reichenberg, Piotr M. Czerski, Humberto Nicolini
Publikováno v:
Cross-Disorder Group of the Psychiatric Genomics Consortium 2019, ' Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders ', Cell, vol. 179, no. 7, pp. 1469-1482.e11 . https://doi.org/10.1016/j.cell.2019.11.020
Cell
Cell, 179(7), 1469-1482.e11. Cell Press
Cell, 179(7), 1469-1482.e11. CELL PRESS
BASE-Bielefeld Academic Search Engine
Cell 179, 1469-1482.e11 (2019)
Walton, E 2019, ' Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders ', Cell, vol. 179, no. 7, pp. 1469-1482.e11 . https://doi.org/10.1016/j.cell.2019.11.020
Cell, 179, 7, pp. 1469-1482.e11
Cross-Disorder Group of the Psychiatric Genomics Consortium 2019, ' Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders ', Cell, vol. 179, no. 7, pp. 1469-1482.e11 . https://doi.org/10.1016/j.cell.2019.11.020
CELL
Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, P H, Nivard, M G, Posthuma, D, Derks, E M, op Landt Slof, M C T, Boomsma, D I, de Geus, E J C, Hottenga, J J, Mbarek, H, Middeldorp, C M, W J H Penninx, B, Cath, D C, Denys, D, Neale, B M & Smoller, J W 2019, ' Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders ', Cell, vol. 179, no. 7, pp. 1469-1482.e11 . https://doi.org/10.1016/j.cell.2019.11.020
Cell, 179, 1469-1482.e11
Cell
Cell, 179(7), 1469-1482.e11. Cell Press
Cell, 179(7), 1469-1482.e11. CELL PRESS
BASE-Bielefeld Academic Search Engine
Cell 179, 1469-1482.e11 (2019)
Walton, E 2019, ' Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders ', Cell, vol. 179, no. 7, pp. 1469-1482.e11 . https://doi.org/10.1016/j.cell.2019.11.020
Cell, 179, 7, pp. 1469-1482.e11
Cross-Disorder Group of the Psychiatric Genomics Consortium 2019, ' Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders ', Cell, vol. 179, no. 7, pp. 1469-1482.e11 . https://doi.org/10.1016/j.cell.2019.11.020
CELL
Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, P H, Nivard, M G, Posthuma, D, Derks, E M, op Landt Slof, M C T, Boomsma, D I, de Geus, E J C, Hottenga, J J, Mbarek, H, Middeldorp, C M, W J H Penninx, B, Cath, D C, Denys, D, Neale, B M & Smoller, J W 2019, ' Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders ', Cell, vol. 179, no. 7, pp. 1469-1482.e11 . https://doi.org/10.1016/j.cell.2019.11.020
Cell, 179, 1469-1482.e11
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 case
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26d336969785045ccdfcaab7d9a110a
http://hdl.handle.net/11585/714034
http://hdl.handle.net/11585/714034
Autor:
Laura Ferraro, Michael John Owen, Tracey L. Petryshen, Franziska Degenhardt, Derek W. Morris, Alexander Richards, Aura Frizzati, Ingrid Agartz, Leonhard Lennertz, Ingrid Melle, Fabian Streit, Jim van Os, Bart P. F. Rutten, Bettina Konte, Valentina Escott-Price, Annette M. Hartmann, Håkan Nyman, Ole A. Andreassen, Jana Strohmaier, Diego Quattrone, John Hubert, Gary Donohoe, Sophie E. Legge, Roel A. Ophoff, Loes M. Olde Loohuis, Amy Lynham, Dan Rujescu, Gabriëlla A.M. Blokland, James T.R. Walters, Jeanne E. Savage, Peter Holmans, Craig Morgan, Erik G. Jönsson, Robin M. Murray, Neeltje E.M. van Haren, Kjetil Sundet, Charlotte Gayer-Anderson, Antonio F. Pardiñas, Donna Cosgrove, Michael Wagner, Marcella Rietschel, Michael Conlon O'Donovan, Aiden Corvin, Patrick F. Sullivan, Thomas Espeseth, Ina Giegling, Katherine E. Tansey, Srdjan Djurovic
Publikováno v:
Schizophrenia bulletin 46, sbz061 (2019). doi:10.1093/schbul/sbz061
Schizophrenia Bulletin, 46(2), 336-344. Oxford University Press
Schizophrenia Bulletin
Schizophrenia bulletin, 46(2), 336-344. Oxford University Press
GROUP Investigators, EUGEI WP2 Group & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2020, ' The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia ', Schizophrenia bulletin, vol. 46, no. 2, pp. 336-344 . https://doi.org/10.1093/schbul/sbz061
Schizophrenia Bulletin, 46(2), 336-344. Oxford University Press
Schizophrenia Bulletin
Schizophrenia bulletin, 46(2), 336-344. Oxford University Press
GROUP Investigators, EUGEI WP2 Group & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2020, ' The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia ', Schizophrenia bulletin, vol. 46, no. 2, pp. 336-344 . https://doi.org/10.1093/schbul/sbz061
Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddac06cf8c487c5349f058ab5f3aebe4
https://pub.dzne.de/record/151594
https://pub.dzne.de/record/151594
Autor:
Vera Guttenthaler, Leonhard Lennertz, Peter Falkai, Friederike Rampacher, Petra Franke, Joachim Klosterkötter, Stephan Ruhrmann, Rainald Mössner, Wolfgang Maier, Hans J. Grabe, Ralf Pukrop, Svenja Schulze-Rauschenbach, Michael Wagner
Publikováno v:
The International Journal of Neuropsychopharmacology; Vol 16
Neuropeptide S (NPS) is a novel central acting neuropeptide that modulates several brain functions. NPS has shown strong anxiolytic-like effects and interactions with other central transmitter systems, including serotonin and glutamate. A coding vari
Autor:
Ingo Frommann, Michael Wagner, Anna Schuhmacher, Ralf Pukrop, Wolfgang Wölwer, Rainald Mössner, Leonhard Lennertz, Anja Steinbrecher, Wolfgang Gaebel, Wolfgang Maier, Joachim Klosterkötter, Martin W. Landsberg, Svenja Schulze-Rauschenbach, Petra Franke, Heinz Häfner, Nadine Petrovsky, Boris B. Quednow, Susanne Höfels
Publikováno v:
The International Journal of Neuropsychopharmacology; Vol 15
The international journal of neuropsychopharmacology / official scientific journal of the Collegium
The international journal of neuropsychopharmacology / official scientific journal of the Collegium
Recently, the neuropeptide S (NPS) neurotransmitter system has been identified as a promising psychopharmacological drug target given that NPS has shown anxiolytic-like and stress-reducing properties and memory-enhancing effects in rodent models. NPS
Autor:
Leonhard Lennertz, Wolfgang Maier, Michael Wagner, Jens Benninghoff, Boris B. Quednow, Rainald Mössner
Publikováno v:
European archives of psychiatry and clinical neuroscience
European Archives of Psychiatry and Clinical Neuroscience; Vol 261
European Archives of Psychiatry and Clinical Neuroscience; Vol 261
Mutations of the transcription factor 4 (TCF4) gene cause mental retardation with or without associated facial dysmorphisms and intermittent hyperventilation. Subsequently, a polymorphism of TCF4 was shown in a genome-wide association study to slight
Autor:
Frank Träber, H. H. Schild, Kai-Uwe Kühn, Nadine Petrovsky, Natascha Fingerhut, Alois M. Sprinkart, Wolfgang Block, Michael Wagner, Frank Jessen, Wolfgang Maier
Publikováno v:
Schizophrenia bulletin 39(1), 197-205 (2011). doi:10.1093/schbul/sbr127
Background : Imbalance of glutamatergic neurotransmission has been proposed as a key mechanism underlying symptoms of schizophrenia. The neuropetide N-acetylaspartylglutamate (NAAG) modulates glutamate release. NAAG provides a component of the proton
Autor:
Nadine Petrovsky, Frank Weiss-Motz, Wolfgang Maier, Ulrich Ettinger, Matthias R. Lemke, Michael Wagner, Stephan Ruhrmann, Joachim Klosterkötter, Svenja Schulze-Rauschenbach, Peter Hornung
Publikováno v:
Journal of Psychiatric Research. 43:291-297
Disturbances of the oculomotor system are promising endophenotypes for schizophrenia. Increased error rates in the antisaccade task and prolonged antisaccade latencies have been found in patients with schizophrenia and their first degree relatives. W
Autor:
Kai-Uwe Kühn, Sibylle G. Schwab, Michael Wagner, Boris B. Quednow, Rainald Mössner, Anna Schuhmacher, Wolfgang Maier
Publikováno v:
Biological Psychiatry. 64:434-437
Background Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT 2A R) has been implicated in both the pathogenesis of