Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Shuai Yuan"'
Autor:
Loukas Zagkos, Héléne T. Cronjé, Benjamin Woolf, Roxane de La Harpe, Stephen Burgess, Christos S. Mantzoros, Paul Elliott, Shuai Yuan, Susanna C. Larsson, Ioanna Tzoulaki, Dipender Gill
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Background Caffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption behaviour and metabolism. This study aimed
Externí odkaz:
https://doaj.org/article/263b49f2ef8b4d119a0652d6d922853e
Autor:
Jie Chen, Xixian Ruan, Tian Fu, Shiyuan Lu, Dipender Gill, Zixuan He, Stephen Burgess, Edward L. Giovannucci, Susanna C. Larsson, Minzi Deng, Shuai Yuan, Xue Li
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105110- (2024)
Summary: Background: The causal associations of physical activity and sedentary behavior with the risk of gastrointestinal disease are unclear. We performed a Mendelian randomization analysis to examine these associations. Methods: Genetic instrument
Externí odkaz:
https://doaj.org/article/97a22ce0e17944c4be795341b78ddc86
Autor:
Fangkun Yang, Fengzhe Xu, Han Zhang, Dipender Gill, Susanna C. Larsson, Xue Li, Hanbin Cui, Shuai Yuan
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background We aimed to investigate the protein pathways linking obesity and lifestyle factors to coronary artery disease (CAD). Methods Summary-level genome-wide association statistics of CAD were obtained from the CARDIoGRAMplusC4D consorti
Externí odkaz:
https://doaj.org/article/3643865179164e72a1f087a3d48d529f
Autor:
Shuai Yuan, Fangyuan Jiang, Jie Chen, Benjamin Lebwohl, Peter H.R. Green, Daniel Leffler, Susanna C. Larsson, Xue Li, Jonas F. Ludvigsson
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105033- (2024)
Summary: Background: Coeliac disease (CeD) has been associated with a broad range of diseases in observational data; however, whether these associations are causal remains undetermined. We conducted a phenome-wide Mendelian randomization analysis (MR
Externí odkaz:
https://doaj.org/article/c4e53b51f70b4682871fb5a18d933ac2
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104934- (2024)
Summary: Background: Mitochondrial dysfunction has been linked to the development of inflammatory bowel disease (IBD), but the genetic pathophysiology was not fully elucidated. We employed Mendelian randomization and colocalization analyses to invest
Externí odkaz:
https://doaj.org/article/23ee806118374e2bba479809b8cffda9
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe interleukin-1 pathway has been linked to pancreatic diseases. We applied the Mendelian randomization approach to explore whether higher interleukin-1 receptor antagonist (IL-1RA) levels reduce the risk of acute and chronic pancreatitis
Externí odkaz:
https://doaj.org/article/c8cb59715d6f4076b4a962703c24988f
Autor:
Shuai Yuan, Jie Chen, Xixian Ruan, Mathew Vithayathil, Siddhartha Kar, Xue Li, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-9 (2022)
Abstract Background The associations of rheumatoid arthritis (RA) with risk of site-specific cancers beyond lymphohematopoietic cancer have been scarcely explored. We conducted a Mendelian randomization investigation of the associations of RA with si
Externí odkaz:
https://doaj.org/article/267e177637e049949877180d09047e49
Autor:
Shuai Yuan, Jing Sun, Ying Lu, Fengzhe Xu, Doudou Li, Fangyuan Jiang, Zhongxiao Wan, Xue Li, Li-Qiang Qin, Susanna C. Larsson
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population. Methods Rs4988235 lo
Externí odkaz:
https://doaj.org/article/09b01d8b26db4ef8bbbb5a8b46714028
Autor:
Han Zhang, Shuai Yuan, Yong Li, Doudou Li, Zengli Yu, Lidan Hu, Xue Li, Yuming Wang, Susanna C. Larsson
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundA bidirectional association between atopic dermatitis and chronic kidney disease (CKD) has been revealed in observational studies, whereas the causality of this association was unclear. We conducted a Mendelian randomization study to determ
Externí odkaz:
https://doaj.org/article/35c6ad206b2746bba991273caa6103b8
Autor:
Jie Chen, Fengzhe Xu, Xixian Ruan, Jing Sun, Yao Zhang, Han Zhang, Jianhui Zhao, Jie Zheng, Susanna C. Larsson, Xiaoyan Wang, Xue Li, Shuai Yuan
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104494- (2023)
Summary: Background: Identifying new drug targets for inflammatory bowel disease (IBD) is urgently needed. The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) and colocalization analyses to
Externí odkaz:
https://doaj.org/article/0e4b5cde8fd24cfeb105e60aa11a923c