Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Simon Lord"'
Autor:
Mark R. Middleton, P S Virdee, Leena Elhussein, Martin Eatock, M Goff, Sharon Love, Anne Thomas, Stephen Falk, Joanna Moschandreas, Richard C. Turkington, D. Alan Anthoney, L Collins, Simon Lord
Publikováno v:
Thomas, A, Virdee, P S, Eatock, M, Lord, S R, Falk, S, Anthoney, D A, Turkington, R C, Goff, M, Elhussein, L, Collins, L, Love, S, Moschandreas, J & Middleton, M R 2020, ' Dual Erb B Inhibition in Oesophago-gastric Cancer (DEBIOC): A phase I dose escalating safety study and randomised dose expansion of AZD8931 in combination with oxaliplatin and capecitabine chemotherapy in patients with oesophagogastric adenocarcinoma ', European Journal of Cancer, vol. 124, pp. 131-141 . https://doi.org/10.1016/j.ejca.2019.10.010
European Journal of Cancer
European Journal of Cancer
Background AZD8931 has equipotent activity against epidermal growth factor receptor, erbB2, and erbB3. Primary objectives were to determine the recommended phase II dose (RP2D) of AZD8931 + chemotherapy, and subsequently assess safety/preliminary cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f3f4d7b04b1b1073ec0ebfa84b2946
https://pure.qub.ac.uk/en/publications/1ea96e9e-4701-4ab7-aa91-f416c1e2f897
https://pure.qub.ac.uk/en/publications/1ea96e9e-4701-4ab7-aa91-f416c1e2f897
Autor:
Syed Haider, Simon Lord, Esther Bridges, Matteo Morotti, Hani Choudhry, Helen Sheldon, Wei-Chen Cheng, Dylan Marc Jones, Deborah C.I. Goberdhan, Nicki Gray, Alessandro Valli, Simon Wigfield, Francesca M. Buffa, Eugene J. Teoh, Alan McIntyre, Adrian L. Harris
Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α (ERα) positive breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here we show that the glutamine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dcb225b6fc1218014391684c935e36
https://doi.org/10.1101/384628
https://doi.org/10.1101/384628
Autor:
Maria Marples, Simon Lord, Patrick Hamilton, Peter Hall, Mehran Afshar, Dan Stark, Jenny F. Seligmann, Paul D. Baxter
Publikováno v:
Afshar, M, Hamilton, P, Seligmann, J, Lord, S, Baxter, P, Marples, M, Stark, D & Hall, P S 2015, ' Can D-Dimer Measurement Reduce the Frequency of Radiological Assessment in Patients Receiving Palliative Imatinib for Gastrointestinal Stromal Tumor (GIST)? ', Cancer investigation, pp. 1-7 . https://doi.org/10.3109/07357907.2015.1047504
Imatinib therapy has improved outcomes in advanced GISTs. Current guidelines suggest monitoring with CT scanning every 12 weeks. There are no validated biomarkers to assist disease evaluation. We identified 50 patients treated with imatinib for GIST
Autor:
Simon Wigfield, Michael J.O. Wakelam, Elena Favaro, Fredrik Karpe, Barrie Peck, Karim Bensaad, Katherine E. Pinnick, Adrian L. Harris, Francesca M. Buffa, Simon Lord, Ji-Liang Li, Qifeng Zhang, Jennifer Collins, Almut Schulze, Caroline A. Lewis
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 349-365 (2014)
Elsevier
Elsevier
Summary: An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were indu
Publikováno v:
Chemical Biology & Drug Design. 75:481-488
Tahanian E, Lord-Dufour S, Das A, Khosla C, Roy R, Annabi B. A better understanding of the metabolic adaptations of the vascular endothelial cells (EC) that mediate tumor vascularization would help the development of new drugs and therapies. Novel ro
Autor:
Shozeb Haider, S Mehta, Ioanna Ledaki, A L Harris, Alan McIntyre, Elena Favaro, K Bensaad, Francesca M. Buffa, Simon Lord, Dean C. Singleton, Hani Choudhry
Publikováno v:
Cancer Research. 73:BS02-1
Background. Hypoxia is recognised to induce a multigene programme mainly via HIF1a and also HIF2a transcription factors. Bioinformatics analysis of multiple gene array data sets in breast cancer showed a core hypoxia response programme of approximate
Autor:
Marie-Claude Mathieu, Alex G. Therien, Virginie Bernier, Yves Boie, Danielle Denis, Simon Lord-Dufour, Jason Burch, Yongxin Han, James R. Mortimer, Patsy Clark
Publikováno v:
Cytokine. 43:257-258
Publikováno v:
Genome Medicine; Vol 3
Genome Medicine
Genome Medicine
Hypoxia is a feature of most solid tumors and is associated with poor prognosis in several cancer types, including breast cancer. The master regulator of the hypoxic response is the Hypoxia-inducible factor 1α (HIF-1α). It is becoming clear that HI