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of 4
pro vyhledávání: '"Michael Biddle"'
Autor:
Michael Biddle, Dawn T. Smallwood, E Castells, Peter Bradding, Katy M. Roach, Cathryn Weston, Yassine Amrani, Viona W. Bowman, Harvinder Virk, Jamie McCarthy, S. Mark Duffy
Publikováno v:
British Journal of Pharmacology. 178:2948-2962
BACKGROUND AND PURPOSE TGFβ1-mediated myofibroblast activation contributes to pathological fibrosis in many diseases including idiopathic pulmonary fibrosis (IPF), where myofibroblast resistance to oxidant-mediated apoptosis is also evident. We ther
Autor:
Himanshu Kaul, Amanda Sutcliffe, Ian D. Pavord, Sherif Gonem, Bindi S. Brook, Rod Smallwood, Davinder Kaur, Andrew J. Wardlaw, Latifa Chachi, Michelle Bourne, Christopher E. Brightling, Amisha Singapuri, Richard Kay, Ruth Saunders, Salman Siddiqui, Rachid Berair, Michael Biddle
Publikováno v:
Science Translational Medicine. 11(479)
Increased airway smooth muscle mass, a feature of airway remodeling in asthma, is the strongest predictor of airflow limitation and contributes to asthma-associated morbidity and mortality. No current drug therapy for asthma is known to affect airway
Autor:
Peter Bradding, Latifa Chachi, Yassine Amrani, Reynold A. Panettieri, Cynthia Koziol-White, Abdulrahman Alzahrani, Michael Biddle, Rehab Bagadood
Publikováno v:
Clinical and experimental immunology. 194(2)
Summary The purpose of this study was to investigate whether growth factors produced by activated human lung mast cells (HLMCs) impair β2-adrenoceptor (β2-AR) function in human airway smooth muscle (ASM) cells. Protein array analysis confirmed the
Autor:
Himanshu Kaul, Michelle Bourne, Ian D. Pavord, Michael Biddle, Ruth Saunders, Gerald Bacher, Salman Siddiqui, Amisha Singapuri, Amanda Sutcliffe, Andrew J. Wardlaw, Igor L. Chernyavsky, Latifa Chachi, Bindi S. Brook, Rod Smallwood, Marie Laurencin, Rachid Berair, Richard Kay, Christopher E. Brightling
Introduction: Asthma is associated with increased airway smooth muscle (ASM) mass with increased disease severity and impaired lung function. The prostaglandin D2 (PGD2) receptor 2 (DP2) antagonist, fevipiprant, reduces airway eosinophilia and improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ddbb08d31a6110baadc73b4e4bb0cc
https://doi.org/10.1183/1393003.congress-2017.oa283
https://doi.org/10.1183/1393003.congress-2017.oa283