Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Cynthia B.E. Chee"'
Autor:
Chen Bai, Jia Mei Hong, Tuan Zea Tan, Alvin Dingyuan Wang, Paul A. Tambyah, Suay Hong Gan, Hoi Wah She, Alicia Tay, Catherine W.M. Ong, Felicia Teo, Josephine Lum, Yu Wang, Amit Singhal, Andres F. Vallejo, Marta E Polak, Yee Tang Wang, Nicholas I. Paton, Qing Hao Miow, Cynthia B.E. Chee, Paul T. Elkington, Jon S. Friedland, Hong Rong Loh, Ying Ding
Publikováno v:
J Clin Invest
BACKGROUND: Matrix metalloproteinases (MMPs) are key regulators of tissue destruction in tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II double-blind, randomized, controlled trial investigating doxycycline, a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde4a7f1352470ce765cbbda6b8babfe
https://europepmc.org/articles/PMC8321570/
https://europepmc.org/articles/PMC8321570/
Autor:
Yee Tang Wang, Suay Hong Gan, Cynthia B.E. Chee, Li Hwei Sng, Kyi Win KhinMar, Leo Kang Yang Lim, Li Wei Ang
Publikováno v:
Open Forum Infectious Diseases
Background Previously treated (ie, recurrent) tuberculosis (TB) cases account for approximately 7%–8% of incident TB globally and in Singapore. Molecular fingerprinting has enabled the differentiation of these patients into relapsed or reinfection
Autor:
John J. Totman, Tow Keang Lim, Yee Tang Wang, Nicholas I. Paton, David W. Townsend, James Thomas Patrick Decourcy Hallinan, Lih Kin Khor, Yan Pang, James S. Molton, Claire M. Naftalin, Benjamin A. Thomas, Cynthia B.E. Chee
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-7 (2019)
BMC Infectious Diseases
BMC Infectious Diseases
Background The understanding of early events following TB exposure is limited by traditional tests that rely on detection of an immune response to infection, which is delayed, or on imaging tests with low sensitivity for early disease. We investigate
Autor:
Leo Kang Yang Lim, Angeline Poh-Gek Chua, S. Tan, Suay-Hong Gan, Li-Hwei Sng, Cynthia B.E. Chee, Yee-Tang Wang
Publikováno v:
D26. CLINICAL AND EPIDEMIOLOGICAL DEVELOPMENTS IN TB.
Publikováno v:
Singapore Med J
INTRODUCTION It is vital to diagnose and treat pulmonary tuberculosis (PTB) early, in the interests of the patient and public health. At the Singapore Tuberculosis Control Unit (TBCU), it was not uncommon to discover abnormal chest radiographs (CXRs)
Publikováno v:
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 23(12)
SETTING: Although diabetes (DM) and low body mass index (BMI) are established risk factors for active tuberculosis (TB), the joint effect of type 2 diabetes (T2D) and BMI is unclear.DESIGN: A prospective cohort of 63,257 adults aged 45–74 years wer
Autor:
Linda Wei Lin Tan, Mark I-Cheng Chen, Yee Tang Wang, Wei-Yen Lim, Kristin Hui Xian Tan, Peiling Yap, Cynthia B.E. Chee, Timothy Barkham
Publikováno v:
International Journal of Infectious Diseases, Vol 72, Iss, Pp 55-62 (2018)
Objectives: This first cross-sectional survey on latent tuberculosis infection (LTBI) in Singapore was performed by utilizing the QuantiFERON Gold In-tube (QFT-GIT) assay to collect data on the prevalence of LTBI and to identify potential risk factor
Publikováno v:
10.2 Tuberculosis.
Background: During the period 2005 to 2015, there were 241 multidrug-resistant (MDR) TB cases diagnosed in Singapore. Of these, 183 (81.7%) were foreign-born. Using spoligotyping and MIRU-VNTR, we determined the pattern of MDRTB transmission in Singa
Autor:
Jo Ann Tay, Pavanish Kumar, Amit Singhal, Karima Larbi, Bhairav Paleja, Jie Yee Siew, Utkan Demirci, ShuQi Wang, Gennaro De Libero, Vigneshwaran Mani, Yee Tang Wang, Cynthia B.E. Chee, Fatih Inci
Publikováno v:
Scientific Reports
Access to point-of-care (POC), rapid, inexpensive, sensitive, and instrument-free tests for the diagnosis of tuberculosis (TB) remains a major challenge. Here, we report a simple and low-cost microchip-based TB ELISA (MTBE) platform for the detection
Autor:
Barry N. Kreiswirth, Gennaro De Libero, Amit Singhal, Yee Tang Wang, Melvin Khee-Shing Leow, Bhairav Paleja, Liu Jie, Francesca Zolezzi, Pavanish Kumar, Jinmiao Chen, Gilla Kaplan, Liana Tsenova, Gan Suay Hong, Michael Poidinger, Natalia Kurepina, Cynthia B.E. Chee
Publikováno v:
Science translational medicine. 6(263)
The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential new approach to TB therapy is to augment protective host immune responses. We report that the antidiabetic drug metformin (MET) reduces the intracellular grow