Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Vincenzo Bronte"'
Autor:
Veronica Batani, Manuela Iezzi, Daniela Righetti, Stefano Ugel, Simone Caligola, Enrico Polati, Pier Giuseppe Pelicci, Walter Mosaner, Claudio Lunardi, Katia Donadello, Francesco De Sanctis, Alessandra Fiore, Varvara Petrova, Simonetta Friso, Federica Facciotti, Lorena Torroni, Andrea Claudio Comel, Paolo Bazzoni, Laura Pinton, Francesca Pizzolo, Mariaelisa Rampudda, Francesca Hofer, Elisa Tinazzi, Rosalinda Trovato, Vincenzo Bronte, Antonio Vella, Stefania Canè, Oliviero Olivieri, Chiara Musiu, Roza Maria Barouni
Publikováno v:
J Clin Invest
BACKGROUNDPatients with coronavirus disease 2019 (COVID-19) develop pneumonia generally associated with lymphopenia and a severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK/ST
Autor:
Viviana Piccolo, Augusto Bleve, Renato Ostuni, Sara Morlacchi, Monica Rimoldi, Chiara Porta, Silvia Tartari, Mario P. Colombo, Alessandro Ippolito, Mariangela Storto, Giulia Soldà, Paola Larghi, Sabina Sangaletti, Stefano Duga, Claudio Tripodo, Tiziana Pressiani, Gioacchino Natoli, Lorenza Rimassa, Laura Strauss, Antonio Sica, Emilio Hirsch, Andrea Doni, Vincenzo Bronte, Stefania Banfi, Fiorella Balzac, Francesca Maria Consonni, Maria Grazia Totaro, Emilia Turco
Publikováno v:
Cancer Research. 80:2874-2888
Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) cells that share the ability to suppress adaptive immunity and to hinder the effectiveness of anticancer treatments. Of note, in response to IFNγ
Autor:
Manuela Iezzi, Katia Donadello, Zheng-Li Shi, Stefano Ugel, Stefania Canè, Ying Chen, Marco Chilosi, Ido Amit, Peter J. Murray, Vincenzo Bronte, Francesca Hofer, Enrico Polati, Evelina Tacconelli, Piera Amelia Iezzi, Andrea Capece, Francesco De Sanctis, Alessandra Fiore, Francesco Domenico Del Pizzo, Leonardo Gottin, Serena Zilio, Silvio Bicciato, Chiara Musiu, Simone Caligola, Roza Maria Barouni, Alessia Lamolinara, Domenico Angelucci, Ildo Polidoro, Paolo Serafini, Cristina Frusteri, Andrea Grilli, Annalisa Adamo, Domenico Girelli
Publikováno v:
Cell Death and Differentiation
Inflammatory responses rapidly detect pathogen invasion and mount a regulated reaction. However, dysregulated anti-pathogen immune responses can provoke life-threatening inflammatory pathologies collectively known as cytokine release syndrome (CRS),
Autor:
Evelina Martinenaite, Annalisa Adamo, Stine Emilie Weis-Banke, Katharina L. Kopp, Maria Perez-Penco, Stefano Ugel, Marion Chapellier, Vincenzo Bronte, Mie Linder Hübbe, Cristina Frusteri, Marco Carretta, Mia Aaboe Jørgensen, Mai-Britt Zocca, Francesco De Sanctis, Ayako Wakatsuki Pedersen, Manuela Iezzi, Mads Hald Andersen, Daniel Hargbøll Madsen
Publikováno v:
Cancer immunology research. 9(11)
Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity of ARG1 promotes the formation of an immunosuppressive microenvironment and leads
Autor:
Vincenzo Bronte, Gian Cesare Tron, Mario P. Colombo, Francesca Maria Consonni, Ubaldina Galli, Massimiliano Mazzone, Ambra A. Grolla, Tiziana Pressiani, Sabina Sangaletti, Claudio Tripodo, Sara Morlacchi, Mariangela Storto, Rosalinda Trovato, Cristina Travelli, Antonio Sica, Paola Portararo, Stefano Ugel, Armando A. Genazzani, Lorenza Rimassa
Publikováno v:
Cancer Research. 79:1938-1951
Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limitin
Publikováno v:
Annual review of pathology. 16
Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic
Autor:
Patrick J. Hanley, Patricia R. M. Rocco, Rachele Ciccocioppo, Jaap Jan Boelens, Catherine M. Bollard, Vincenzo Bronte, Bruce L. Levine, Daniel J. Weiss, Maria Cancio
Publikováno v:
Cytotherapy
Coronavirus disease 2019 (SARS-CoV2) is an active global health threat for which treatments are desperately being sought. Even though most people infected experience mild to moderate respiratory symptoms and recover with supportive care, certain vuln
Autor:
Vincenzo Bronte
Publikováno v:
Cancer Immunol Res
Patients with ulcerative colitis (UC) have an increased risk of developing colitis-associated colon cancer (CACC). Changes in glycosylation of the oncoprotein MUC1 commonly occur in chronic inflammation, including UC, and this abnormally glycosylated
Autor:
Vincenzo Bronte, Stefania Canè
Immunotherapy has emerged as a potent alternative for cancer treatment, unfortunately, the clinical benefit remains limited to few patients and immunotherapy resistance due to immunosuppressive tumor microenvironment represents the major reason of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea48df9716da4a529122467a97f0085
http://hdl.handle.net/11562/1011089
http://hdl.handle.net/11562/1011089
Autor:
Takahiro Yamazaki, Paule Opolon, Connie P.M. Duong, Pierre Olivier Gaudreau, Gabriele Madonna, Vancheswaran Gopalakrishnan, Antje Sucker, Miles C. Andrews, Dirk Schadendorf, Laurence Zitvogel, Meriem Messaoudene, Aurélien Marabelle, Christophe Klein, Guido Kroemer, Ilaria Marigo, Sonia Becharef, Gautier Stoll, Maria Paula Roberti, Vincenzo Bronte, Shin Foong Ngiow, David Enot, Stefano Ugel, Marie Vétizou, Jennifer A. Wargo, Jean-Charles Soria, Armelle Prévost-Blondel, Mark J. Smyth, Loic Verlingue, Romain Daillère, Paolo A. Ascierto, Gladys Ferrere, Nicolas Jacquelot, Alexander M.M. Eggermont
Publikováno v:
Cell Research
Cell Research, Nature Publishing Group, 2019, 29 (10), pp.846-861. ⟨10.1038/s41422-019-0224-x⟩
Cell Research, Nature Publishing Group, 2019, 29 (10), pp.846-861. ⟨10.1038/s41422-019-0224-x⟩
PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy. Delineating mechanisms of secondary resistance to this strategy is increasingly important. Here, we identified the deleterious role of signaling via the type I interfero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b22afc98490dccf70839b753d988e71
https://hal.archives-ouvertes.fr/hal-02461559
https://hal.archives-ouvertes.fr/hal-02461559