Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mizue Terai"'
Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma
Autor:
Bao Quoc Lam, Takahito Sugase, Meggie Danielson, Mizue Terai, Andrew E. Aplin, Takami Sato, J. Silvio Gutkind
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Journal of Translational Medicine
Journal of Translational Medicine
Background Patients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of diverse MUM cell lines and appropriate animal models. We previously reported th
Autor:
Mital Shah, Takami Sato, Bharat Awsare, Rajiv A. Kabadi, Mizue Terai, Gautam George, Gregary D. Marhefka
Publikováno v:
Tex Heart Inst J
Locoregional cytokine treatment, or immunoembolization, is an experimental targeted therapy for uveal melanoma metastatic to the liver. Unlike systemic cytokine treatments that have been associated with substantial toxicity, this method of drug deliv
Autor:
Bao Lam, Eric Londin, Takami Sato, Emma O. Link, Ankit K. Rochani, Gagan Kaushal, Alok Bhushan, Mizue Terai, Marlana Orloff
Publikováno v:
Cancers
Volume 12
Issue 2
Cancers, Vol 12, Iss 2, p 405 (2020)
Volume 12
Issue 2
Cancers, Vol 12, Iss 2, p 405 (2020)
Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal melanoma (MUM) is highly resistant to immunotherapy. One of the mechanisms for resistance wou
Autor:
Yuri Sykulev, Mizue Terai, Sergey Panteleev, Nicholas William Mazzanti, Nadia Anikeeva, Takami Sato
Publikováno v:
The Journal of Biological Chemistry
Although CAR-T cells are widely used to treat cancer, efficiency of CAR-T cell cytolytic responses has not been carefully examined. We engineered CAR specific for HMW-MAA (high-molecular-weight melanoma-associated antigen) and evaluated potency of CD
Autor:
Michael J. Guarino, Min Xiao, Giorgos C. Karakousis, Michael A. Davies, Andrea Watters, Ensar Halilovic, Gao Zhang, Alexander Roesch, Lauren E. Haydu, Giordano Caponigro, Keith T. Flaherty, Clemens Krepler, Katrin Sproesser, Gordon B. Mills, Sébastien Jeay, Andrew E. Aplin, Lynn M. Schuchter, Nicholas J. Petrelli, Joseph J. Bennett, Adina Vultur, David E. Elder, Meenhard Herlyn, Ravi K. Amaravadi, Michael Feldman, Xiangfan Yin, Melissa Wilson, Tara C. Gangadhar, Rakesh Kumar, Michela Perego, Carol L. Shields, Katherine L. Nathanson, Marilda Beqiri, Jennifer A. Wargo, Matthias Ocker, Takami Sato, Qin Liu, Michal Barzily-Rokni, Batool Shannan, Ioannis N. Anastopoulos, Dennie T. Frederick, Bradley Garman, Xiaowei Xu, Dave S.B. Hoon, Mizue Terai, Randall W Ryan, Yiling Lu, Bradley Wubbenhorst, Patricia Brafford, Matthew B. Boxer, Annette O. Walter, Wei Xu, Jens Wuerthner, Steve Angus, David B. Darr
Publikováno v:
Cell Reports, Vol 21, Iss 7, Pp 1953-1967 (2017)
Summary: Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitat
Autor:
Inna Chervoneva, Michael J. Mastrangelo, David Berd, Kashyap Patel, Mizue Terai, Takami Sato, Amit Mahipal
Publikováno v:
Cancer Immunology, Immunotherapy. 60:1039-1045
Interleukin-10 (IL-10) downregulates T-cell-mediated immune responses. We studied the association between IL-10 production by freshly isolated melanoma cell suspensions in vitro and overall survival in patients undergoing adjuvant treatment with a va
Publikováno v:
Cancer Research. 78:3805-3805
Uveal (eye) melanoma (UM) is the most common primary eye malignancy in adults. Despite effective treatments for primary UM, up to 50% of patients subsequently develop systemic metastasis, predominantly in the liver. Once hepatic metastasis develops,
Autor:
Senthamil R. Selvan, Yutaka Tamura, Mizue Terai, Michael J. Mastrangelo, Takami Sato, Vitali Alexeev
Publikováno v:
Immunologic research. 51(2-3)
IL-10 is an immunomodulatory cytokine that is frequently upregulated in various types of cancer. The biological role of IL-10 in cancer is quite complex; however, the presence of IL-10 in advanced metastases and the positive correlation between serum
Autor:
Michael J. Mastrangelo, Masumi Eto, David Berd, Kenichi Harigaya, Mizue Terai, Garbo D. Young, Yutaka Tamura, Takami Sato
Publikováno v:
Cancer immunology, immunotherapy : CII. 61(2)
We previously reported that substantial amounts of IL-10, an immunomodulatory cytokine, are produced by cell suspensions of fresh human metastatic melanoma tissues. Production diminished with continuous culturing of cells, which suggests a pivotal in
Autor:
Inna Chervoneva, Jerry A. Shields, Carin F. Gonsalves, Michael J. Mastrangelo, Akira Yamamoto, MaryAnn Laudadio, Carol L. Shields, Takami Sato, David Berd, Kevin L. Sullivan, Mizue Terai, David J. Eschelman, Matias E. Valsecchi
Publikováno v:
Journal of Vascular and Interventional Radiology. 26:523-532.e2
To investigate the effects of immunoembolization with granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with uveal melanoma (UM) with liver-only metastasis.In this double-blind phase II clinical trial, patients were randomized to