Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Melvin Khee-Shing Leow"'
Autor:
Marielle V. Fortier, Navin Michael, Peter D. Gluckman, Kuan Jin Lee, NNeerja Karnani, Suresh Anand Sadananthan, Li Chen, Izzuddin M. Aris, Christiani Jeyakumar Henry, Melvin Khee-Shing Leow, Fabian Kok Peng Yap, S. Sendhil Velan, Aparna Sampathkumar, Keith M. Godfrey, See Ling Loy, Lynette Pei-Chi Shek, Hong Pan, Yung Seng Lee, Michael S. Kramer, Mya Thway Tint, Varsha Gupta, Yap Seng Chong
Publikováno v:
International Journal of Obesity (2005)
Background/Objectives Accumulation of lipid droplets inside skeletal muscle fibers (intramyocellular lipids or IMCL) with increasing obesity has been linked to skeletal muscle insulin resistance and risk of type 2 diabetes in both adults and prepuber
Autor:
Navin Michael, Zhiling Chan, Cherlyn Ding, Melvin Khee-Shing Leow, Yu Chung Chooi, Faidon Magkos, S. Sendhil Velan, Suresh Anand Sadananthan, John Choo
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:127-136
Context - The prevalence of diabetes is increasing throughout Asia, even in the absence of obesity, and is lower in women than in men. The underlying mechanisms are not well understood. Objective - To evaluate the sex differences in glucose and fatty
Autor:
Cherlyn Ding, Leonie Egli, Nabil Bosco, Lijuan Sun, Hui Jen Goh, Khung Keong Yeo, Jonathan Jiunn Liang Yap, Lucas Actis-Goretta, Melvin Khee-Shing Leow, Faidon Magkos
Publikováno v:
Frontiers in Nutrition
Ding, C, Egli, L, Bosco, N, Sun, L, Goh, H J, Yeo, K K, Yap, J J L, Actis-Goretta, L, Leow, M K-S & Magkos, F 2021, ' Plasma branched-chain amino acids are associated with greater fasting and postprandial insulin secretion in non-diabetic Chinese adults ', Frontiers in Nutrition, vol. 8, 664939 . https://doi.org/10.3389/fnut.2021.664939
Frontiers in Nutrition, Vol 8 (2021)
Ding, C, Egli, L, Bosco, N, Sun, L, Goh, H J, Yeo, K K, Yap, J J L, Actis-Goretta, L, Leow, M K-S & Magkos, F 2021, ' Plasma branched-chain amino acids are associated with greater fasting and postprandial insulin secretion in non-diabetic Chinese adults ', Frontiers in Nutrition, vol. 8, 664939 . https://doi.org/10.3389/fnut.2021.664939
Frontiers in Nutrition, Vol 8 (2021)
Background:Plasma branched-chain amino acids (BCAA) are consistently elevated in subjects with obesity and type 2 diabetes (T2DM) and correlate with insulin resistance. The association of BCAA with insulin secretion and clearance rates has not been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88523e7edc5e20e7806012cab8c33ab2
https://hdl.handle.net/10356/151755
https://hdl.handle.net/10356/151755
Publikováno v:
Journal of Theoretical Biology, 419, 333-342
Journal of Theoretical Biology, 419, pp. 333-342
Journal of Theoretical Biology, 419, pp. 333-342
Contains fulltext : 174792.pdf (Publisher’s version ) (Closed access) Glucose plasma measurements for diabetes patients are generally presented as a glucose concentration-time profile with 15-60min time scale intervals. This limited resolution obsc
OBJECTIVES: The study was to investigate how a rice-based meal composed of rice, vegetable (green leaf) and meat (breast of chicken) when presented in different order of sequence, impacts on postprandial glycaemia. METHODS: In a randomized controlled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759c77531bf7924e349bde61efc898a4
https://europepmc.org/articles/PMC6574673/
https://europepmc.org/articles/PMC6574673/
Autor:
Melvin Khee-Shing Leow, Christiani Jeyakumar Henry, Lijuan Sun, Hui Jen Goh, Priya Govindharajulu
Background: Previous studies have shown that the sequential order of consuming different food components significantly impacts postprandial glucose and insulin excursions in prediabetes and type 2 diabetes, but the causative mechanisms in healthy hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e34d945e672279f6f00e9f5615a703
https://hdl.handle.net/10356/145004
https://hdl.handle.net/10356/145004
Autor:
Melvin Khee-Shing Leow, Sze Han Lee, Siok Ching Chia, Christiani Jeyakumar Henry, Sumanto Haldar, Joseph Lim, Eric Chun Yong Chan
Publikováno v:
European journal of nutrition. 58(1)
Purpose: To investigate acute effects of two doses of a polyphenol-rich curry made with seven different spices and four base vegetables, eaten with white rice, on 24 h glucose response, postprandial insulinemia, triglyceridemia and 24 h urinary total
Autor:
Peter D. Gluckman, Yung Seng Lee, Sudarsanareddy Lokireddy, Patnam Sreekanth, Radiance Lim, Hillary Chua, Tai E. Shyong, Craig McFarlane, Sabeera Bonala, Khoo Chin Meng, Ravi Kambadur, Jackie Ang, Mridula Sharma, Melvin Khee-Shing Leow, Marcus Lee
Publikováno v:
Molecular Endocrinology. 27:1518-1535
Obesity is associated with insulin resistance and abnormal peripheral tissue glucose uptake. However, the mechanisms that interfere with insulin signaling and glucose uptake in human skeletal muscle during obesity are not fully characterized. Using m
Publikováno v:
New England Journal of Medicine. 367:1761-1764
Autor:
Paul M. Yen, Rohit A. Sinha, Ronny Lesmana, Judy Sng, Xiao Hui Liao, Melvin Khee-Shing Leow, Kenji Ohba, Brijesh K. Singh, Samuel Refetoff, Sujoy Ghosh
Publikováno v:
Endocrinology. 157(4)
Clinical symptoms may vary and not necessarily reflect serum thyroid hormone (TH) levels during acute and chronic hyperthyroidism as well as recovery from hyperthyroidism. We thus examined changes in hepatic gene expression and serum TH/TSH levels in