Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kenneth J. Livak"'
Autor:
Matthew S. Davids, Robert J. Soiffer, Emma S. Hathaway, F. Stephen Hodi, Pavan Bachireddy, Magdalena Thurin, Vincent T. Ho, Wandi Zhang, Sarah Nikiforow, Nicoletta Cieri, Jerome Ritz, Stacey Gabriel, Mariano Severgnini, Aashna Jhaveri, X. Shirley Liu, Haesook T. Kim, Jingxin Fu, Kenneth J. Livak, Sacha Gnjatic, Scott J. Rodig, Alexandra Savell, Philippe Armand, Catherine J. Wu, Teddy Huang, Joseph H. Antin, Corey Cutler, Carrie Cibulskis, Livius Penter, Shuqiang Li, Howard Streicher, Donna Neuberg, Srinika Ranasinghe, Matthew Nazzaro, Yi Zhang, Emily M. Thrash, Helen X. Chen, John Koreth, Seunghee Kim-Schulze
Publikováno v:
Blood
Relapsed myeloid disease after allogeneic stem cell transplantation (HSCT) remains largely incurable. We previously demonstrated the potent activity of immune checkpoint blockade in this clinical setting with ipilimumab or nivolumab. To define the mo
Autor:
Satyen H. Gohil, Teddy Huang, Dominik Schmidt, F. Stephen Hodi, Kenneth J. Livak, Donna Neuberg, Catherine J. Wu, Emily M. Thrash, Mariano Severgnini, Robert Zeiser, Livius Penter, Pavan Bachireddy, Shuqiang Li
Publikováno v:
Blood Advances
Key Points Index case of nivolumab response associated with altered circulating T-cell composition and heterogeneous PD-L1 expression on AML blasts.Single-cell approaches provide complementary insight into cellular mechanisms of response and resistan
Autor:
Patrick C. Lee, Shuqiang Li, Charles H. Yoon, Jing Sun, Jason Pyrdol, Zoe B. Ciantra, J. Bryan Iorgulescu, Jinyan Liu, Donna E. Leet, Anita Giobbie-Hurder, Donna Neuberg, Satyen H. Gohil, Teddy Huang, Edward F. Fritsch, Wandi Zhang, Adrienne M. Luoma, Mohamed Uduman, Siranush Sarkizova, Kai W. Wucherpfennig, Giacomo Oliveira, Dan H. Barouch, Liudmila Elagina, Nir Hacohen, Oriol Olive, Lars Rønn Olsen, Zhuting Hu, Elizabeth I. Buchbinder, Derin B. Keskin, Sachet A. Shukla, Robert A. Redd, Bradley L. Pentelute, Patrick A. Ott, Scott J. Rodig, Catherine J. Wu, Keerthi Shetty, Kenneth J. Livak, Pavan Bachireddy, Rosa Lundbye Allesøe, Rebecca L. Holden, Lauren Peter, Juliet Forman
Publikováno v:
Hu, Z, Leet, D E, Allesøe, R L, Oliveira, G, Li, S, Luoma, A M, Liu, J, Forman, J, Huang, T, Iorgulescu, J B, Holden, R, Sarkizova, S, Gohil, S H, Redd, R A, Sun, J, Elagina, L, Giobbie-Hurder, A, Zhang, W, Peter, L, Ciantra, Z, Rodig, S, Olive, O, Shetty, K, Pyrdol, J, Uduman, M, Lee, P C, Bachireddy, P, Buchbinder, E I, Yoon, C H, Neuberg, D, Pentelute, B L, Hacohen, N, Livak, K J, Shukla, S A, Olsen, L R, Barouch, D H, Wucherpfennig, K W, Fritsch, E F, Keskin, D B, Wu, C J & Ott, P A 2021, ' Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma ', Nature Medicine, vol. 27, no. 3, pp. 515-525 . https://doi.org/10.1038/s41591-020-01206-4
Nat Med
Hu, Z, Leet, D E, Allesøe, R L, Oliveira, G, Li, S, Luoma, A M, Liu, J, Forman, J, Huang, T, Iorgulescu, J B, Holden, R, Sarkizova, S, Gohil, S H, Redd, R A, Sun, J, Elagina, L, Giobbie-Hurder, A, Zhang, W, Peter, L, Ciantra, Z, Rodig, S, Olive, O, Shetty, K, Pyrdol, J, Uduman, M, Lee, P C, Bachireddy, P, Buchbinder, E I, Yoon, C H, Neuberg, D, Pentelute, B L, Hacohen, N, Livak, K J, Shukla, S A, Olsen, L R, Barouch, D H, Wucherpfennig, K W, Fritsch, E F, Keskin, D B, Wu, C J & Ott, P A 2021, ' Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma ', Nature Medicine, vol. 27, pp. 515-525 . https://doi.org/10.1038/s41591-020-01206-4
Nat Med
Hu, Z, Leet, D E, Allesøe, R L, Oliveira, G, Li, S, Luoma, A M, Liu, J, Forman, J, Huang, T, Iorgulescu, J B, Holden, R, Sarkizova, S, Gohil, S H, Redd, R A, Sun, J, Elagina, L, Giobbie-Hurder, A, Zhang, W, Peter, L, Ciantra, Z, Rodig, S, Olive, O, Shetty, K, Pyrdol, J, Uduman, M, Lee, P C, Bachireddy, P, Buchbinder, E I, Yoon, C H, Neuberg, D, Pentelute, B L, Hacohen, N, Livak, K J, Shukla, S A, Olsen, L R, Barouch, D H, Wucherpfennig, K W, Fritsch, E F, Keskin, D B, Wu, C J & Ott, P A 2021, ' Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma ', Nature Medicine, vol. 27, pp. 515-525 . https://doi.org/10.1038/s41591-020-01206-4
Personal neoantigen vaccines have been envisioned as an effective approach to induce, amplify and diversify antitumor T cell responses. To define the long-term effects of such a vaccine, we evaluated the clinical outcome and circulating immune respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb0d71266b86a21a801f1370e5a7c0f
https://orbit.dtu.dk/en/publications/380c54f4-6c21-4388-8a77-6cbca07d517d
https://orbit.dtu.dk/en/publications/380c54f4-6c21-4388-8a77-6cbca07d517d
Publikováno v:
Nat Rev Clin Oncol
Advances in molecular biology, microfluidics and bioinformatics have empowered the study of thousands or even millions of individual cells from malignant tumours at the single-cell level of resolution. This high-dimensional, multi-faceted characteriz
Autor:
Catherine J. Wu, Shuqiang Li, Dana Pe'er, Jerome Ritz, Pavan Bachireddy, Christina Ennis, Robert J. Soiffer, Zi-Ning Choo, Vinhkhang N Nguyen, Cassandra Burdziak, Elham Azizi, Kenneth J. Livak, Donna Neuberg, Edwin P. Alyea
Immune therapies have transformed the cancer therapeutic landscape but fail to benefit most patients. To elucidate the underlying mechanisms by which T cells mediate elimination of leukemia, we generated a high-resolution map of longitudinal T cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80a0ae51165fd3310473c96a8fa7e900
https://doi.org/10.1101/2020.07.08.194332
https://doi.org/10.1101/2020.07.08.194332
Autor:
Jonna Grimsby, Saumyadipta Pyne, Prapti Pokharel, Akira Tsuda, Steven J. Mentzer, Willi L. Wagner, Maximilian Ackermann, Andrew B. Servais, Robert D. Bennett, Paul C. Blainey, Cristian D. Valenzuela, Shuqiang Li, Kenneth J. Livak, Alexandra B. Ysasi
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Frontiers in Medicine
Frontiers in Medicine
Lung regeneration occurs in a variety of adult mammals after surgical removal of one lung (pneumonectomy). Previous studies of murine post-pneumonectomy lung growth have identified regenerative “hotspots” in subpleural alveolar ducts; however, th
Autor:
Nicoletta Cieri, Donna Neuberg, Shuqiang Li, Neil G. Ruthen, Dana Pe'er, Haesook T. Kim, Christina Ennis, Robert J. Soiffer, Jerome Ritz, Cameron Y. Park, Zhongqi Ge, Vinhkhang N Nguyen, Katie Maurer, Zi-Ning Choo, Pavan Bachireddy, Edwin P. Alyea, Satyen H. Gohil, Derin B. Keskin, Cassandra Burdziak, Kenneth J. Livak, Elham Azizi, Catherine J. Wu
Publikováno v:
Cell Rep
Summary To elucidate mechanisms by which T cells eliminate leukemia, we study donor lymphocyte infusion (DLI), an established immunotherapy for relapsed leukemia. We model T cell dynamics by integrating longitudinal, multimodal data from 94,517 bone
Autor:
Wandi Zhang, Srinika Ranasinghe, Donna Neuberg, Kenneth J. Livak, Jerome Ritz, Robert J. Soiffer, Livius Penter, Yi Zhang, Satyen H. Gohil, Shuqiang Li, Teddy Huang, Haesook T. Kim, Pavan Bachireddy, Robert Zeiser, Nicoletta Cieri, Alexandra Savell, X. Shirley Liu, Catherine J. Wu, Matthew S. Davids
Publikováno v:
Blood. 136:34-35
Relapse after allogeneic hematopoietic stem cell transplantation (HSCT) remains an unmet medical need. The ETCTN 9204 study evaluated in 71 study subjects if immune checkpoint blockade with anti-CTLA-4 (Ipilimumab (Ipi), n = 43) or anti-PD-1 (Nivolum
Autor:
Gabrielle Bouchard, Wenxin Xu, David L. Cookmeyer, Bradley Alexander McGregor, Kelly Street, Ziad Bakouny, Arlene H. Sharpe, Christina B. Pedersen, Lucas Pomerance, Nicholas Schindler, Sachet A. Shukla, Erica Maria Pimenta, Rafael A. Irizarry, Kathleen M. Mahoney, John A. Steinharter, Ang Cui, Kelly P. Burke, Juliet Forman, Steven L. Chang, Michelle S. Hirsch, Maxine Sun, Catherine J. Wu, Lars Rønn Olsen, Sabina Signoretti, David A. Braun, Derin B. Keskin, Toni K. Choueiri, Kenneth J. Livak, Shuqiang Li, Yue Hou, David F. McDermott, Satyen H. Gohil, Teddy Huang, Laure Hirsch, Thomas Denize
Publikováno v:
Cancer Cell
The tumor immune microenvironment plays a critical role in cancer progression and response to immunotherapy in clear cell renal cell carcinoma (ccRCC), yet the composition and phenotypic states of immune cells in this tumor are incompletely character
Autor:
Donna Neuberg, Shuqiang Li, Jerome Ritz, Christina Ennis, Edwin P. Alyea, Robert J. Soiffer, Dana Pe'er, Vinhkhang N Nguyen, Kenneth J. Livak, Catherine J. Wu, Pavan Bachireddy, Cassandra Burdziak, Zi Ning Choo, Elham Azizi
Publikováno v:
Cancer Research. 81:LT008-LT008
Immune therapies have transformed the cancer therapeutic landscape but fail to benefit most patients. To elucidate the underlying mechanisms by which T cells mediate elimination of leukemia, we generated a high-resolution map of longitudinal T cell d