Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jan Tavernier"'
Autor:
Bart Vandekerckhove, Anje Cauwels, Gilles Uzé, An Goethals, Stijn De Munter, Nele Vanderroost, Alexander Van Parys, Frank Peelman, Jan Tavernier, Jennyfer Bultinck, Peter Brouckaert, Annick Verhee, Jeroen Hostens, Leander Huyghe, Sandra Van Lint, Niko Kley, Lennart Zabeau
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, ⟨10.15252/emmm.201911223⟩
EMBO MOLECULAR MEDICINE
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, ⟨10.15252/emmm.201911223⟩
EMBO MOLECULAR MEDICINE
Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index. A TNF‐based
Autor:
Stefaan De Koker, Yann Bordat, Thomas Wueest, Sandra Van Lint, Dominiek Catteeuw, Gilles Uzé, José Van der Heyden, Annick Verhee, Alexander Van Parys, Anje Cauwels, Geneviève Garcin, Niko Kley, Jan Tavernier, Franciane Paul, Bart Vandekerckhove, Elke Rogge, Sarah Gerlo
Publikováno v:
Cancer Research
Cancer Research, American Association for Cancer Research, 2018, 78 (2), pp.463-474. ⟨10.1158/0008-5472.CAN-17-1980⟩
Cancer Research, American Association for Cancer Research, 2018, 78 (2), pp.463-474. ⟨10.1158/0008-5472.CAN-17-1980⟩
An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy cells and remain active in case of recurrence. Furthermore, it should preferably not rely on tumor-specific surface markers, as the
Autor:
Anje Cauwels, Sarah Gerlo, Jan Tavernier, Jennyfer Bultinck, Gilles Uzé, Yann Bordat, Annick Verhee, José Van der Heyden, Lode De Cauwer, Geneviève Garcin, Franciane Paul, Sandra Van Lint, Dominiek Catteeuw, Elke Rogge
Publikováno v:
OncoImmunology, Vol 7, Iss 3 (2018)
OncoImmunology
OncoImmunology, Taylor & Francis, 2017, 7 (3), pp.e1398876. ⟨10.1080/2162402X.2017.1398876⟩
OncoImmunology
OncoImmunology, Taylor & Francis, 2017, 7 (3), pp.e1398876. ⟨10.1080/2162402X.2017.1398876⟩
International audience; Despite approval for the treatment of various malignancies, clinical application of cytokines such as type I interferon (IFN) is severely impeded by their systemic toxicity. AcTakines (Activity-on-Target cytokines) are optimiz
Autor:
Jan Tavernier, Kenny Roose, Lien Van Hoecke, Alexander Van Parys, Xavier Saelens, Stefaan De Koker, Sandra Van Lint, Johan Grooten, Peter Vandenabeele
Publikováno v:
Cell Stress
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
NATURE COMMUNICATIONS
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
NATURE COMMUNICATIONS
Cancer immunotherapy can induce durable antitumor responses. However, many patients poorly respond to such therapies. Here we describe a generic antitumor therapy that is based on the intratumor delivery of mRNA that codes for the necroptosis executi
Autor:
Niek N. Sanders, Stefan Lienenklaus, Sandra Van Lint, Sunil A. David, Kim Deswarte, Zifu Zhong, Stefaan De Koker, João Paulo Portela Catani, Bruno G. De Geest, Lutz Nuhn, Jan Tavernier, Bart N. Lambrecht, Yupeng Li, Francis Combes
Publikováno v:
Advanced Materials, 30(45):1803397. Wiley-Blackwell
Localized therapeutic modalities that subvert the tumor microenvironment from immune-suppressive to pro-immunogenic can elicit systemic antitumor immune responses that induce regression of directly treated as well as nontreated distal tumors. A key t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab507c6cb8917c20af341c3cd1f794ae
https://pure.eur.nl/en/publications/cb3c0b78-b21c-4d06-9543-ca3e98288456
https://pure.eur.nl/en/publications/cb3c0b78-b21c-4d06-9543-ca3e98288456
Autor:
Catarina Xavier, Kevin Van der Jeught, Matthias D'Huyvetter, Tony Lahoutte, Ahmet Krasniqi, Jan Tavernier, Serge Muyldermans, José Van der Heyden, Nick Devoogdt
Anti-CD20 radioimmunotherapy is an effective approach for therapy of relapsed or refractory CD20pos lymphomas, but faces limitations due to poor tumor penetration and undesirable pharmacokinetics of full antibodies. Camelid single-domain Ab fragments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0e2db8577a4ffa2f938493a70720ed
https://hdl.handle.net/20.500.14017/7e1bb7f8-ff7a-461b-8940-b26013579f08
https://hdl.handle.net/20.500.14017/7e1bb7f8-ff7a-461b-8940-b26013579f08
Publikováno v:
Journal of Endocrinology. 223:T9-T23
Leptin plays a central role in the control of body weight and energy homeostasis, but is a pleiotropic cytokine with activities on many peripheral cell types. In this review, we discuss the interaction of leptin with its receptor, and focus on the st
Autor:
Savvas N. Savvides, Jan Tavernier, Yehudi Bloch, Frank Peelman, Laurens Vyncke, Loes van Schie, Ewald Pauwels, Kenneth Verstraete
Publikováno v:
Nature Structural & Molecular Biology. 21:375-382
Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediat
Autor:
Dries Van Rompaey, Ann Dansercoer, Frank Peelman, Guy Lippens, Rudi Beyaert, Juan José Marín López, Isabel Vandenberghe, Kenneth Verstraete, Jan Tavernier, Harald Braun, Hans De Winter, Savvas N. Savvides, Bart N. Lambrecht, Kris Pauwels, Hamida Hammad
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), 17 p. ⟨10.1038/ncomms14937⟩
Nature Communications, 2017, 8 (1), 17 p. ⟨10.1038/ncomms14937⟩
Nature Communications (8), 17 p.. (2017)
Nature communications
NATURE COMMUNICATIONS
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), 17 p. ⟨10.1038/ncomms14937⟩
Nature Communications, 2017, 8 (1), 17 p. ⟨10.1038/ncomms14937⟩
Nature Communications (8), 17 p.. (2017)
Nature communications
NATURE COMMUNICATIONS
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP
Autor:
Jan Tavernier
Publikováno v:
Cancer Immunology Research. 7:A158-A158
An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy cells and remain active in case of recurrence. Furthermore, it should preferably not rely on tumor-specific surface markers, as the