Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Brooke Benner"'
Autor:
Carly Pilcher, Bhavana Konda, Manisha H. Shah, Robert Wesolowski, William E. Carson, Himanshu Savardekar, Claire F. Verschraegen, Logan Good, Gregory K. Behbehani, Brooke Benner, Christian Ghattas, Dwight H. Owen, Gregory A. Otterson, Ruthann Norman
Publikováno v:
Clin Lung Cancer
Structured Abstract: Background Immune checkpoint inhibitors are now an approved treatment for patients with extensive- stage small cell lung cancer (SCLC), an aggressive and incurable malignancy. However, the median survival for patients remains aro
Autor:
Brooke Benner, Phillip G. Popovich, Jonathan Lifshitz, Chelsea E. Bray, Daniel B. McKim, Kristina G. Witcher, Daniel S. Eiferman, Rachel K. Rowe, Olga N. Kokiko-Cochran, Jonathan P. Godbout, Julia E. Dziabis
Publikováno v:
Glia
Microglia undergo dynamic structural and transcriptional changes during the immune response to traumatic brain injury (TBI). For example, TBI causes microglia to form rod-shaped trains in the cerebral cortex, but their contribution to inflammation an
Autor:
Amanda Campbell, Akaansha Ganju, Stephen V. Liu, Sarvani Uppati, Kala M. Levine, Bonnie Paul, Tiffany Noel, Elizabeth L. McMichael, Gonzalo N. Olaverria Salavaggione, Panos Savvides, William E. Carson, Melanie E. Davis, Lakhvir S. Atwal, Michael A. Caligiuri, Theodoros N. Teknos, Nicholas B. Courtney, Thomas Olencki, Kallan Williams, Megan C. Duggan, Brooke Benner, Susheela Tridandapani, Kyle A. Martin, Xiaokui Mo, John C. Byrd
Publikováno v:
Clin Cancer Res
Purpose: mAbs including cetuximab can induce antibody-dependent cellular cytotoxicity (ADCC) and cytokine production mediated via innate immune cells with the ability to recognize mAb-coated tumors. Preclinical modeling has shown that costimulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fcefe11987d7a560074b271108d065
https://europepmc.org/articles/PMC6697573/
https://europepmc.org/articles/PMC6697573/
Autor:
Kallie Jiang, John Harrison Howard, Amanda Campbell, William E. Carson, Thomas A. Mace, Megan C. Duggan, Robert A. Baiocchi, Susheela Tridandapani, Luke Scarberry, Brooke Benner, Gabriella Lapurga, Emily Smith, Lorena P. Suarez-Kelly, Jonathan P. Butchar
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Background Tumor-associated macrophages (TAM) are expanded and exhibit tumor-promoting properties within the tumor microenvironment. Current methods to study TAM have not been replicated across cancer types and often do not include exogenous growth f
Autor:
Andrew Stiff, Robert Wesolowski, William E. Carson, Himanshu Savardekar, Megan C. Duggan, Logan Good, Darren Wethington, Luke Scarberry, Brooke Benner, Steven Sun, Jack Hedberg, Gabby Lapurga
Publikováno v:
Cancer Research. 80:3414-3414
Myeloid derived suppressor cells (MDSCs) antagonize antitumor immune responses, and limit the efficacy of immune based therapies for cancer. As a result, MDSCs have garnered attention as therapeutic targets. Unfortunately, there has been limited succ
Autor:
Thomas A. Mace, Megan C. Duggan, Rachel M. Layman, Andrew Stiff, Daniel G. Stover, Jeffrey VanDeusen, Maryam B. Lustberg, Mathew Cherian, Robert Wesolowski, Zaibo Li, Brooke Benner, Sagar Sardesai, Lianbo Yu, William E. Carson, Christopher McQuinn, Himanshu Savardekar, Hiroaki Nitta, Erin Macrae, Bhuvaneswari Ramaswamy, Dionisia Quiroga, Nicole Williams, Mahmoud Kassem
Publikováno v:
Cancer Research. 80:5514-5514
While combinations of immune checkpoint (ICP) inhibitors and neo-adjuvant chemotherapy (NAC) have begun to be tested in patients with breast cancer (BC), chemotherapeutic effects on ICP expression in circulating T cells are still unclear. This inform
Autor:
Reena Shakya, Anne M. Noonan, Kriti Agrawal, Bradley W. Blaser, Mary Dillhoff, Thomas A. Mace, Phil A. Hart, Fouad Choueiry, Brooke Benner, Darwin L. Conwell, Zobeida Cruz-Monserrate, William E. Carson, Alice Hinton, Molly Torok, Jami Shaffer, Terence M. Williams, Anna Deems, Xue-Feng Bai
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundA significant challenge to overcome in pancreatic ductal adenocarcinoma (PDAC) is the profound systemic immunosuppression that renders this disease non-responsive to immunotherapy. Our supporting data provide evidence that CD200, a regulato
Autor:
Amanda Campbell, Prashant Trikha, Robert Wesolowski, Michael A. Caligiuri, Brooke Benner, David Abood, Elizabeth L. McMichael, Kari Kendra, Matthew O. Old, Andrew Stiff, Thomas Olencki, Lianbo Yu, Thomas A. Mace, Natarajan Muthusamy, John Harrison Howard, Nancy Stasik, William E. Carson, Shalini Gautam, John C. Byrd, Megan C. Duggan, Susheela Tridandapani, Vincent Hsu, Bethany L. Mundy-Bosse, Ian Landi
Purpose: mAbs are used to treat solid and hematologic malignancies and work in part through Fc receptors (FcRs) on natural killer cells (NK). However, FcR-mediated functions of NK cells from patients with cancer are significantly impaired. Identifyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a59ee230f10c5623ca41b2a5bc3e08
https://europepmc.org/articles/PMC7184799/
https://europepmc.org/articles/PMC7184799/