Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrew C. Adams"'
Publikováno v:
The Journal of nutrition. 148(4)
Background Supplementation of a high-fat obesogenic diet (HFD) with cholic acid (CA) suppresses the development of obesity, insulin resistance, and hepatic steatosis in mice. Objective We investigated the role of fibroblast growth factor 21 (FGF21) i
Autor:
C. Ronald Kahn, Manimozhiyan Arumugam, Kristin I. Stanford, Graham Smyth, Christine C. Cheng, Brice Emanuelli, Alexei Kharitonenkov, Mervyn D. Michael, Sara G. Vienberg, Andrew C. Adams
Publikováno v:
Journal of Clinical Investigation. 124:515-527
The hormone FGF21 regulates carbohydrate and lipid homeostasis as well as body weight, and increasing FGF21 improves metabolic abnormalities associated with obesity and diabetes. FGF21 is thought to act on its target tissues, including liver and adip
Autor:
Andrew C. Adams, Yongde Luo, Christine C. Cheng, Chaofeng Yang, Tamer Coskun, Ruth E. Gimeno, Alexei Kharitonenkov
Publikováno v:
Molecular Metabolism. 2(1):31-37
FGF21 is a multifunctional metabolic regulator. The co-factor βKlotho (KLB) allows FGF21 to signal via FGF receptors. Given the widespread nature of FGFR expression and KLB presence in several organs, it remains unclear which tissue/FGFR isoform det
Autor:
Stephen E. Flaherty, Andrew C. Adams, Shuangyu Lu, Nicholas Douris, Eleftheria Maratos-Flier, Avery B. Forrow, Melissa J. Chee, Arnaud Monnard
Olanzapine (OLZ), an atypical antipsychotic, can be effective in treating patients with restricting type anorexia nervosa who exercise excessively. Clinical improvements include weight gain and reduced pathological hyperactivity. However the neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad20bd6e96e74bef866102fa3984dcd2
https://europepmc.org/articles/PMC4609648/
https://europepmc.org/articles/PMC4609648/
Autor:
Julia M. Assini, Andrew C. Adams, Erin E. Mulvihill, Sanjiv S. Chhoker, Amy C. Burke, Dawn E. Telford, Maria Drangova, Murray W. Huff, Cynthia G. Sawyez, Christopher L. Pin, Alexei Kharitonenkov, Brian G. Sutherland
Publikováno v:
Bone and Joint Institute
Medical Biophysics Publications
Medical Biophysics Publications
The molecular mechanisms and metabolic pathways whereby the citrus flavonoid, naringenin, reduces dyslipidemia and improves glucose tolerance were investigated in C57BL6/J wild-type mice and fibroblast growth factor 21 (FGF21) null (Fgf21−/−) mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef258a0226aa02d1118ad05630d44fe9
https://ir.lib.uwo.ca/boneandjointpub/384
https://ir.lib.uwo.ca/boneandjointpub/384
Autor:
Marc K. Hellerstein, Matthew D. Bruss, Alexei Kharitonenkov, Andrew C. Adams, Airlia C. S. Thompson, Nitish Nag
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 11, p e111418 (2014)
PLoS ONE, Vol 9, Iss 11, p e111418 (2014)
Calorie restriction (CR) delays aging and extends lifespan in numerous organisms, including mice. Down-regulation of the somatotropic axis, including a reduction in insulin-like growth factor-1 (IGF-1), likely plays an important role in CR-induced li
Autor:
Alexei Kharitonenkov, Mark R. Wade, Joseph T. Brozinick, Hai H. Bui, Philipp E. Scherer, Yukiko Miyauchi, William L. Holland, Ming Shang Kuo, Christine M. Kusminski, Ruth Gordillo, Steven M. Bauer, Katherine Volk, Esha Singhal, Christine C. Cheng, Andrew C. Adams
SummaryFGF21, a member of the fibroblast growth factor (FGF) superfamily, has recently emerged as a regulator of metabolism and energy utilization. However, the exact mechanism(s) whereby FGF21 mediates its actions have not been elucidated. There is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f972c3e8f55d1b0b3a412c88867ef4e
https://europepmc.org/articles/PMC3667496/
https://europepmc.org/articles/PMC3667496/
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 297(5)
In mice of normal weight and with diet-induced obesity, a high-fat, low-carbohydrate ketogenic diet (KD) causes weight loss, reduced circulating glucose and lipids, and dramatic changes in hepatic gene expression. Many of the effects of KD are mediat
Autor:
Carolyn A. Halstead, Vincent L. Reynolds, Sharon R. Myers, Holly W. Smith, Armando R. Irizarry, Alexei Kharitonenkov, Victor J. Wroblewski, Barbara C. Hansen, Andrew C. Adams, Jennifer A. Martin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e65763 (2013)
PLoS ONE, Vol 8, Iss 6, p e65763 (2013)
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that represents a promising target for the treatment of several metabolic diseases. Administration of recombinant wild type FGF21 to diabetic animals leads to a dramatic improvement i
Autor:
James W. Perfield, Christopher J. Gaffney, Francis B. Stephens, Dennis P. Smith, Jo E. Lewis, Francis J. P. Ebling, Christine C. Cheng, Luke Norton, Ricardo J. Samms, Andrew C. Adams, Kostas Tsintzas, Tony Butterfield
Context Fibroblast growth factor 21 (FGF21) secretion has been shown to respond directly to carbohydrate consumption, with glucose, fructose, and sucrose all reported to increase plasma levels of FGF21 in rodents and humans. However, carbohydrate con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3065d11da150d0f10f621ba4bcbf0d14