Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dashyant Dhanak"'
Publikováno v:
Cell chemical biology. 24(9)
Advances in understanding the role and molecular mechanisms underlying immune surveillance and control of (pre)malignancies is revolutionizing clinical practice in the treatment of cancer. Presently, multiple biologic drugs targeting the immune check
Autor:
Breen Ann L, Lance Ridgers, David G. Tew, Dashyant Dhanak, Arun C. Kaura, Paddy Lavery, George Burton, Andrew West, Dinubhai H. Shah, Richard M. Keenan, Michael G. Darcy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3677-3682
A novel class of CMV protease inhibitors based on a benzothiopyran-S,S-dioxide nucleus has been discovered. Enzyme kinetic data supports a reversible mode of inhibition for a representative member of this class, 2-(3-pyridyl-N-oxide)benzothiopyran-4-
Autor:
Catherine E. Peishoff, John O. Link, Arun C. Kaura, Dashyant Dhanak, Kyle Elrod, Michael G. Darcy, George Burton, Dinubhai H. Shah, Richard M. Keenan, Lisa T. Christmann
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(20)
A versatile synthetic route to a novel series of bis-imidazolemethanes designed to inhibit the hCMV protease has been developed and a series of potential metal binding inhibitors has been identified. In selectivity assays, the compounds were highly s