Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yong J. Lee"'
Autor:
Eun Kyung Lee, Seul Gi Yoon, Chang Sik Choi, Hanho Shin, Dong H. Son, Jung Hyuck Park, Ki Woo Kim, Jung Eun Kim, Jun Gi Rho, Wook Kim, Ji H. Han, Juhwan Yoon, Je K. Seong, Il Yong Kim, Byung Joo Song, Yong J. Lee
Publikováno v:
Diabetes, obesitymetabolism. 20(9)
Aim To analyze the metabolic parameters and adipose tissue inflammation via NLRP3 inflammasome following chronic treatment of mouse models of obesity with AJ5018 as the peripherally restricted cannabinoid 1 receptor (CB1R) antagonist. Materials and m
Autor:
Marco A. Alcala, Hyounsoo Uh, Yong J. Lee, Ruth A. Modzelewski, Shu Ying Kwan, Kristy A. Gogick, David L. Bartlett, Stéphane Petoud, Adam R. Meier, Matthias Bischof, Chad M. Shade, Timothy G. Strein, Charles K. Brown, Zachary P. Thompson
Publikováno v:
Biomaterials
Biomaterials, Elsevier, 2011, 32 (35), pp.9343-52. ⟨10.1016/j.biomaterials.2011.07.076⟩
Biomaterials, Elsevier, 2011, 32 (35), pp.9343-52. ⟨10.1016/j.biomaterials.2011.07.076⟩
International audience; We have created a dendrimer complex suitable for preferential accumulation within liver tumors and luminescence imaging by substituting thirty-two naphthalimide fluorophores on the surface of the dendrimer and incorporating ei
Publikováno v:
Journal of Biological Chemistry. 286:20087-20099
Here, we demonstrate that troglitazone (Rezulin), a peroxisome proliferator-activated receptor agonist, acted in synergy with heregulin to induce massive cell death in breast cancer cells. Although the combination of heregulin and troglitazone (HRG/T
Publikováno v:
FEBS Journal. 276:2278-2284
Hepatic apoptosis is elevated in patients with non-alcoholic steatohepatitis and is correlated with the severity of the disease. Long-chain saturated fatty acids, such as palmitate, induce apoptosis in liver cells. The present study examined adiponec
Publikováno v:
Biochemical Pharmacology. 75:2345-2355
The aim of this study was to investigate the effect of quercetin, a flavonoid, on the apoptotic pathway in a human prostate cell line (LNCaP). We observed that treatment of cells for 24h with quercetin-induced cell death in a dose-dependent manner. A
Autor:
Evangelia G. Kranias, Xiaoyang Zhou, Jiang Qian, Muhammad Ashraf, Yigang Wang, Guoli Chen, Yong J. Lee, Qunying Yuan, Guojie Song, Guo-Chang Fan
Publikováno v:
Circulation Research. 99:1233-1242
Chronic stimulation of the β-adrenergic neurohormonal axis contributes to the progression of heart failure and mortality in animal models and human patients. In cardiomyocytes, activation of the β-adrenergic pathway has been shown to result in tran
Publikováno v:
International Journal of Hyperthermia. 22:713-728
This study investigated whether hyperthermia can enhance TRAIL-induced apoptotic death.Human prostate adenocarcinoma DU-145, human pancreatic carcinoma MIA PaCa-2 and BxPC-3, human colon fibroblast CCD-33Co and rat prostate endothelial YPEN-1 cells w
Autor:
Teresa G. Hastings, Jun Chen, Yong J. Lee, Armando P. Signore, Qinghua Liang, Zhongfang Weng, Amber D. Van Laar
Publikováno v:
Journal of Neurochemistry. 96:428-443
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of midbrain dopaminergic neurons. In the present study, erythropoietin, a trophic factor that has both hematopoietic and neural protective characteristics, was invest
Publikováno v:
Clinical Cancer Research. 11:7607-7613
Purpose and Experimental Design: Previously, we observed that the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK1) is mediated through the activation of apoptosis signal–regulating kinase 1 (ASK1) as a
Autor:
Yong J. Lee, Seok Joon Kwon
Publikováno v:
Clinical Cancer Research. 11:4694-4700
Purpose and Experimental Design: Tumor microenvironment is characterized by regions of fluctuating and chronic hypoxia, low extracellular pH, and nutrient depletion. Although it is well known that hypoxia stimulates the accumulation of hypoxia-induci