Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Leslie A. Lange"'
Autor:
Stephen S. Rich, Donna Neuberg, Michael H. Cho, Bing Yu, Matthew Leventhal, George T. O'Connor, Ani Manichaikul, Weiwei Shi, Lynette M. Sholl, Michael C. Honigberg, Abhishek Niroula, Benjamin L. Ebert, Joselyn Rojas-Quintero, R. Graham Barr, Matthew Moll, Stephanie J. London, L. Adrienne Cupples, Siddhartha Jaiswal, Elizabeth C. Oelsner, Brittany E Sandoval, Pradeep Natarajan, Brian E. Cade, Peter van Galen, Susan Redline, Yohannes Tesfaigzi, Christopher J. Gibson, Stephanie M. Gogarten, COPDGene Study Investigators, Deepti Jain, Adolfo Correa, Bruce D. Levy, Sina A. Gharib, Peter Miller, Kaushik Viswanathan, Caroline A. Owen, Edwin K. Silverman, Lillian Werner, Jerome I. Rotter, Dandi Qiao, Brian C. Miller, Adam S. Sperling, Leslie A. Lange, Alexander G. Bick, Marie McConkey, Vasan S. Ramachandran
Publikováno v:
Blood. 139:357-368
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the disease are incompletely understood. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-related state in which somatic
Autor:
Maggie A. Stanislawski, Dana Dabelea, Jessica R Shaw, Ethan M. Lange, Kylie K. Harrall, Deborah H. Glueck, Leslie A. Lange, Sridharan Raghavan, Elizabeth Litkowski
Publikováno v:
Diabetes Care
OBJECTIVE The metabolic phenotype of youth-onset type 2 diabetes (T2D) differs from that of adult-onset T2D, but little is known about genetic contributions. We aimed to evaluate the association between a T2D genetic risk score (GRS) and traits relat
Autor:
Marie-France Hivert, Ethan M. Lange, Sridharan Raghavan, Ruby Fore, Elizabeth Litkowski, Emily Oken, Maggie A. Stanislawski, Sheryl L. Rifas-Shiman, Dana Dabelea, Leslie A. Lange
Publikováno v:
Pediatric Reports
Volume 13
Issue 2
Pages 36-288
Pediatric Reports, Vol 13, Iss 36, Pp 279-288 (2021)
Volume 13
Issue 2
Pages 36-288
Pediatric Reports, Vol 13, Iss 36, Pp 279-288 (2021)
To examine whether BMI-associated genetic risk variants modify the association of intrauterine diabetes exposure with childhood BMI z-scores, we assessed the interaction between 95 BMI-associated genetic variants and in utero exposure to maternal dia
Autor:
Jeffrey B. Kopp, Neil A. Zakai, Bryan T. Mott, Lydia H. Pecker, Amy Parker Ruhl, Orlando M. Gutiérrez, Marguerite R. Irvin, Neal Jeffries, Rakhi P. Naik, Yu Yang, Cheryl A. Winkler, Mary Cushman, Hans Ackerman, Amit Patki, Leslie A. Lange
Publikováno v:
J Am Soc Nephrol
BACKGROUND: α-Globin is expressed in endothelial cells of resistance arteries, where it limits endothelial nitric oxide signaling and enhances α-adrenergic–mediated vasoconstriction. α-Globin gene (HBA) copy number is variable in people of Afric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8841d7e8120a90b9b5a46636152f8a18
https://europepmc.org/articles/PMC8763181/
https://europepmc.org/articles/PMC8763181/
Autor:
James G. Wilson, Jessica R Shaw, Paul L. Auer, Ake T. Lu, Neil A. Zakai, Mary Cushman, Steve Horvath, Kelsey Grinde, Mindy D. Szeto, Leslie A. Lange, Deborah A. Nickerson, Marsha M. Wheeler, Laura M. Raffield, Amarise Little, Alexander P. Reiner, Marguerite R. Irvin, Ethan M. Lange, Timothy A. Thornton
Publikováno v:
J Thromb Haemost
Background Prospective studies have suggested higher factor VIII (FVIII) levels are an independent risk factor for coronary heart disease (CHD) and stroke. However, limited information, including on genetic and epigenetic contributors to FVIII variat
Autor:
David J. Stott, Christopher J. O'Donnell, Nuno R. Zilhão, Eric A. Whitsel, Fangui Sun, Leslie A. Lange, Xiuqing Guo, Kerri L. Wiggins, Hanfei Xu, Aishwarya Sundaresan, Dennis O. Mook-Kanamori, Christy L. Avery, Albert V. Smith, Xiaohui Li, Til Stürmer, Ayush Giri, Raymond Noordam, Joshua C. Bis, Walter Palmas, Adolfo Correa, Laura M. Raffield, Peter Rossing, Rikki M. Tanner, Tarunveer S. Ahluwalia, James A. Stewart, Helen R. Warren, Jie Yao, Colleen M. Sitlani, Vilmundur Gudnason, Adrienne Cupples, James S. Floyd, Bruce M. Psaty, Jerome I. Rotter, Marguerite R. Irvin, Jacklyn N. Hellwege, Donna K. Arnett, Adriana M. Hung, Ching-Ti Liu, Nita A. Limdi, Stella Trompet, Todd L. Edwards, Lenore J. Launer, J. Wouter Jukema, Ian Ford
Publikováno v:
Am J Hypertens
American Journal of Hypertension, 32(12), 1146-1153. OXFORD UNIV PRESS
American journal of hypertension, vol 32, iss 12
American Journal of Hypertension, 32(12), 1146-1153. OXFORD UNIV PRESS
American journal of hypertension, vol 32, iss 12
BACKGROUND Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described. METHODS We conducted a case–control genome-wide association study of aTRH among persons treated for hypertension, using
Autor:
Peitao Wu, Giulianini Franco, Daniel I. Chasman, Jerome I. Rotter, Georgy Hindy, Tom G. Richardson, M. Arfan Ikram, Ping An, Rafael R C Cuadrat, Jørgen K. Kanters, Sridharan Raghavan, Paul M. Ridker, Rita R. Kalyani, Jonas L. Isaksen, Morten S. Olesen, Xiuqing Guo, André G. Uitterlinden, Marju Orho-Melander, Lluís Masana, Lisa R. Yanek, Iyas Daghlas, Mohsen Ghanbari, Mary F. Feitosa, Jennifer A. Brody, Jose C Florez, Ulrika Ericson, James S. Floyd, Bianca Porneala, Jianwen Cai, Dhananjay Vaidya, Jee-Young Moon, James B. Meigs, George Davey Smith, Ching-Ti Liu, Susanne Jäger, Maryam Kavousi, Josée Dupuis, Christina Ellervik, Qibin Qi, Fariba Ahmadizar, Matthias B. Schulze, Mark O. Goodarzi, Dipender Gill, Josep M Mercader, Bruce M. Psaty, Laura M. Raffield, Leslie A. Lange, Colleen M. Sitlani, Robert C. Kaplan, Jie Yao, Jordi Merino, Michael A. Province
Publikováno v:
Wu, P, Moon, J-Y, Daghlas, I, Franco, G, Porneala, B C, Ahmadizar, F, Richardson, T G, Isaksen, J L, Hindy, G, Yao, J, Sitlani, C M, Raffield, L M, Yanek, L R, Feitosa, M F, Cuadrat, R R C, Qi, Q, Arfan Ikram, M, Ellervik, C, Ericson, U, Goodarzi, M O, Brody, J A, Lange, L, Mercader, J M, Vaidya, D, An, P, Schulze, M B, Masana, L, Ghanbari, M, Olesen, M S, Cai, J, Guo, X, Floyd, J S, Jäger, S, Province, M A, Kalyani, R R, Psaty, B M, Orho-Melander, M, Ridker, P M, Kanters, J K, Uitterlinden, A, Davey Smith, G, Gill, D, Kaplan, R C, Kavousi, M, Raghavan, S, Chasman, D I, Rotter, J I, Meigs, J B, Florez, J C, Dupuis, J, Liu, C-T & Merino, J 2022, ' Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol ', Diabetes Care, vol. 45, no. 1, pp. 232-240 . https://doi.org/10.2337/dc21-1284
Diabetes Care
Diabetes Care, 45(1), 232-240. American Diabetes Association Inc.
Diabetes Care
Diabetes Care, 45(1), 232-240. American Diabetes Association Inc.
OBJECTIVE LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown. RESEARCH DESIGN AND METHODS We cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec7b0060cf74d3856c84b0064ada0e0
https://doi.org/10.2337/figshare.16826305.v1
https://doi.org/10.2337/figshare.16826305.v1
Autor:
Mary Cushman, Neil A. Zakai, Leslie A. Lange, Monika M. Safford, Marguerite R. Irvin, Diego Adrianzen Herrera, Insu Koh, Damon E. Houghton, Radhika Gangaraju, Smita Bhatia
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
Background Individual blood cell count abnormalities have been associated with cardiovascular disease and increased mortality. In this study, we defined a “cytopenia phenotype,” reflecting bone marrow hypoproliferation, to determine if peripheral
Autor:
Stefan Weiss, Gauti Kjartan Gislason, Matthew J. Budoff, Valborg Gudmundsdottir, Xiuqing Guo, Lawrence F. Bielak, Joshua C. Bis, Jie Yao, Latchezar Dimitrov, Leslie A. Lange, Patricia A. Peyser, Lingyi Lu, Vilmundur Gudnason, Jerome I. Rotter, Barry I. Freedman, Lihua Wang, M. Arfan Ikram, Mohsen Ghanbari, Yingchang Lu, Jiaxi Zhu, Elias F Gudmundsson, Gerardo Heiss, Yi-Ping Fu, Maryam Kavousi, Shih-Jen Hwang, Sharon L.R. Kardia, Laura M. Raffield, André G. Uitterlinden, Carl D. Langefeld, Donald W. Bowden, Ping An, Daniel Bos, Kent D. Taylor, Ulf Schminke, Albert V. Smith, Bruce M. Psaty, James G. Wilson, Shyh-Huei Chen, Maggie C.Y. Ng, Christopher J. O'Donnell, Mary F. Feitosa, Nora Franceschini
Publikováno v:
Circ Genom Precis Med
Circulation: Genomic and Precision Medicine, 14(4):E003258. Lippincott Williams & Wilkins
Circulation. Genomic and precision medicine, vol 14, iss 4
Circulation: Genomic and Precision Medicine, 14(4):E003258. Lippincott Williams & Wilkins
Circulation. Genomic and precision medicine, vol 14, iss 4
Background: Coronary artery calcification (CAC) and carotid artery intima-media thickness (cIMT) are measures of subclinical atherosclerosis in asymptomatic individuals and strong risk factors for cardiovascular disease. Type 2 diabetes (T2D) is an i
Autor:
Kendra Ferrier, Laura M. Raffield, Mindy D. Szeto, Paul L. Auer, Jonathan A. Shortt, Colton Leavitt, Leslie A. Lange, Nels C. Olson, Maggie A. Stanislawski, Alexander P. Reiner, Mariah Meyer, Russell P. Tracy, Timothy A. Thornton, Ethan M. Lange, Neil A. Zakai
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: sCD14 (soluble CD14) is a circulating pattern recognition receptor involved in inflammatory signaling. Although it is known that sCD14 levels vary by race, information on the genetic and cardiovascular disease (CVD) risk relationships of s