Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joshua R. Cook"'
Autor:
Kartik Sehgal, Claire McGroder, David S. Seres, Behnood Bikdeli, Daniel Shalev, Anna S. Nordvig, Donald Dietz, Akinpelumi A Beckley, Donald W. Landry, Allan Schwartz, Christine Kim Garcia, John P. Bilezikian, Tejasav S. Sehrawat, Jacob S. Stevens, Domenico Accili, Nadia Liyanage-Don, Aakriti Gupta, Elana J. Bernstein, John C. Ausiello, Gregg F. Rosner, Nir Uriel, Elaine Wan, Ani Nalbandian, Neha Ahluwalia, Sumit Mohan, Toni K. Choueiri, Mahesh V. Madhavan, Joshua R. Cook, Daniel E. Freedberg, Daniel Brodie, Matthew R. Baldwin, Caroline Der-Nigoghossian, Mitchell S.V. Elkind, Jean M. Connors
Publikováno v:
Nat Med
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06ab025d3721105a3b45a10b352296a
https://europepmc.org/articles/PMC8893149/
https://europepmc.org/articles/PMC8893149/
Autor:
Susan Restaino, Charles Marboe, Joshua R. Cook, Edward Lin, Jamie Diamond, Nicholas O. Palmeri, Rachel Bijou
Publikováno v:
Circulation: Heart Failure. 13
Publikováno v:
Diabetes
Hypothalamic neurons expressing agouti-related peptide (AgRP) regulate eating and glucose metabolism. Ablation of FOXO1 in AgRP neurons of mice results in reduced food intake, leanness, improved glucose homeostasis, and increased sensitivity to insul
Autor:
Paqui G. Través, Gautam Bandyopadhyay, Domenico Accili, Li Qiang, Ariane Pessentheiner, Joshua R. Cook, Olivia Osborn, Jerrold M. Olefsky, Jachelle M. Ofrecio, Joanne C. McNelis, Cristina Llorente Izquierdo, Pingping Li, Andrew M.F. Johnson, Heekyung Chung, Da Young Oh, Rafael Mayoral
Publikováno v:
Molecular Metabolism, Vol 4, Iss 5, Pp 378-391 (2015)
Molecular Metabolism
Molecular Metabolism
Objective Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcrip
Autor:
Joshua R. Cook, Robert K. Semple
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:1544-1554
Adiponectin is a highly abundant plasma protein synthesized nearly exclusively in adipose tissue from the ADIPOQ gene. It has excited intense interest because of robust correlation of its circulating levels with indices of insulin resistance (IR) and
Autor:
Fanny Langlet, Christoph Buettner, Daniel Lindén, Kumiko S. Aizawa, Domenico Accili, Ling Wang, Rebecca A. Haeusler, Elke Ericson, Anders Johansson, Joshua R. Cook, Tyrrell Norris
Publikováno v:
Cell. 171:824-835.e18
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of glucokinase, respectively. The tight c
Publikováno v:
The Journal of biological chemistry. 290(22)
The development of insulin resistance (IR) in the liver is a key pathophysiologic event in the development of type 2 diabetes. Although insulin loses its ability to suppress glucose production, it largely retains its capacity to drive lipogenesis. Th
Autor:
Shaoping Deng, Zhiyong Gao, Ryan K. Wong, MieJung Park, Bryan A. Wolf, David A. York, Ali Naji, Jichun Yang, Joshua R. Cook, James F. Markmann, Jianmei Wu
Publikováno v:
Diabetes. 55:193-201
We have recently shown that leucine culture upregulates ATP synthase beta-subunit (ATPSbeta) and increases ATP level, cytosolic Ca(2+), and glucose-induced insulin secretion in rat islets. The aim is to test whether glucokinase expression is also aff
Autor:
Roger Gutierrez-Juarez, Joshua R. Cook, Mark A. Febbraio, Kirsten Hartil, Rebecca A. Haeusler, Irwin J. Kurland, Isabel Arrieta-Cruz, Helene L. Kammoun, Domenico Accili, Colette M. Knight, Bhavapriya Vaitheesvaran
Publikováno v:
Nature communications
Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as glycogen and triglyceride. In type 2 diabetes, levels of the former are low and the latter are exaggerated, posing a pathophysiologic and therapeutic conundrum
Autor:
Jianmei Wu, Claudia E. Robert-Cooperman, Jason R. Carnegie, Camella G. Wilson, Jichun Yang, Robert A. Young, Brant R. Burkhardt, Joshua R. Cook, Bryan A. Wolf
Publikováno v:
Diabetes
OBJECTIVE Pancreatic-derived factor (PANDER, FAM3B) is a pancreatic islet-specific cytokine-like protein that is secreted from β-cells upon glucose stimulation. The biological function of PANDER is unknown, and to address this we generated and chara