Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jingwu Xie"'
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that has an unfavorable outcome and a high rate of relapse. Autophagy plays a vital role in the development of and therapeutic responses to leukemia. This study identif
Publikováno v:
OncoTargets and therapy
The Hedgehog (Hh) pathway is critical for cell differentiation, tissue polarity, and stem cell maintenance during embryonic development, but is silent in adult tissues under normal conditions. However, aberrant Hh signaling activation has been implic
Autor:
Dongsheng Gu, Xiaoben Liu, Seung Young Lee, Samuel Chen, Bing Song, Jingwu Xie, Shovik Bandyopadhyay, Stephen F. Konieczny, Junjie Li, Ji-Xin Cheng, Timothy L. Ratliff
Publikováno v:
Oncogene
Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumula
Publikováno v:
Journal of Biomedical Research
Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is a leading cause of cancer-related death in the US, with a dismal median survival of 6 months. Thus, there is an urgent unmet need to identify ways to diagnose and to treat this dea
Publikováno v:
Archives of Toxicology. 89:179-191
Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in regulation of differentiation, proliferation, tissue polarity, stem c
Autor:
Jingwu Xie, Masato Fujisawa, Wen-Chin Huang, Akinobu Gotoh, Fray F. Marshall, Xiangyan Li, Katsumi Shigemura, Haiyen E. Zhau, Guodong Zhu, Leland W.K. Chung
Publikováno v:
The Prostate. 71:1711-1722
BACKGROUND Sonic hedgehog (Shh) signaling plays a pivotal role in stromal-epithelial interaction during normal development but its role in tumor-stromal interaction during carcinogenic progression is less well defined. Since hormone refractory prosta
Publikováno v:
Chinese Journal of Cancer
Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintena
Autor:
Jingwu Xie, Beiqin Yu
Publikováno v:
Acta biochimica et biophysica Sinica. 48(1)
Gastric cancer is the third leading cause of cancer-related death worldwide. Our basic understanding of gastric cancer biology falls behind that of many other cancer types. Current standard treatment options for gastric cancer have not changed for th
Autor:
Robert E. Emerson, Andrea Caperell-Grant, Kiyotaka Hitomi, Jingwu Xie, Daniela Matei, Salvatore Condello, Jiyoon Lee, Bakhtiyor Yakubov
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 21(19)
Purpose: Aggressive pancreatic cancer is commonly associated with a dense desmoplastic stroma, which forms a protective niche for cancer cells. The objective of the study was to determine the functions of tissue transglutaminase (TG2), a Ca2+-depende
Autor:
Kai Chen, Patrick A. Adegboyega, Jing He, Jingwu Xie, Xiaoli Zhang, Josh Sultz, Xiaoli Ma, Shuhong Huang, Yuanxin Zhang, Tao Sheng, Hongwei Zhang
Publikováno v:
International Journal of Cancer. 118:139-148
The hedgehog pathway plays a critical role in the development of the foregut. However, the role of the hedgehog pathway in primary esophageal cancers is not well studied. Here, we report that elevated expression of hedgehog target genes occurs in 14