Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Hongzhen Li, Peter B. Crino, Wen Li, David H. Gutmann, Erik J. Uhlmann, Jeffrey E. DeClue, Kevin C. Ess
Publikováno v:
Glia. 46:28-40
Individuals with tuberous sclerosis complex (TSC) exhibit a variety of neurologic abnormalities, including mental retardation, epilepsy, and autism. Examination of human TSC brains demonstrate dysplastic astrocytes and neurons, areas of abnormal neur
Autor:
Jeffrey E. DeClue, Steven Kaddu, Phuong-Anh Vu, Michael W. Johnson, Matthias Volkenandt, Harry V. Vinters, Christian A. Sander, Heidi Rust, Ingrid Fackler, Ralf Wienecke, Heinz Kutzner, Arno Rütten
Publikováno v:
Journal of Cutaneous Pathology. 30:174-177
Background: Angiofibromas occur sporadically, and they develop in most patients with tuberous sclerosis complex (TSC), which is associated with alterations of the tumor suppressor genes TSC1 or TSC2. Loss of tuberin, the protein product of TSC2, has
Autor:
Ralf Wienecke, Neil A. Swanson, Eckart Klemm, Sarolta Karparti, Jeffrey E. DeClue, Andrew Green
Publikováno v:
Journal of Cutaneous Pathology. 29:287-290
Background: Patients affected with tuberous sclerosis complex (TSC) are prone to the development of multiple benign tumors of the skin and other organs. Tuberin, the protein product of the tuberous-sclerosis-complex-2 tumor suppressor gene (TSC2) has
Autor:
Raymond S. Yeung, Ralf Wienecke, Jeffrey E. DeClue, Michael J. Flaig, Ingrid Fackler, Adelheid Rust, Christian A. Sander, Matthias Volkenandt, Phuong-Anh Nguyen-Vu
Publikováno v:
Journal of Cutaneous Pathology. 28:470-475
Background: Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited disorder associated with an alteration of the TSC2 tumor suppressor gene which encodes for the protein product tuberin. The disease is characterized by the development
Autor:
Giovanna Benvenuto, Nancy Ratner, Bo Ling, William C. Vass, David Viskochil, Shaowei Li, Sue C. Heffelfinger, Jeffrey E. DeClue, Wen Rui
Publikováno v:
Journal of Clinical Investigation. 105:1233-1241
We have found that EGF-R expression is associated with the development of the Schwann cell-derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack E
Autor:
Michael E. Mendelsohn, Takateru Izumi, Russell Ross, Margaret Wu, Jeffrey E. DeClue, Mark Majesky, Martha Vaughan, Victor J. Ferrans, Pauline M. Barnes, Joseph P. Lynch, Douglas B. Flieder, Rex C. Yung, Anne E. Tattersfield, Gerald J. Beck, Nilo A. Avila, Kateri Gabriele, Mary Ehrmantraut, Elbert P. Trulock, Barry L. Fanburg, Joel Moss, Anil Menon, Suzanne Oparil, Jean-François Cordier, Marilyn K. Glassberg, William D. Travis, Kurt R. Stenmark, Marco W T Schreurs, Peter B. O'Donovan, Eugene J. Sullivan, Clara C. Chen, Shan Chu, Mark D. Schluchter, Carol E. Vreim, Stephen Groft
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 159:679-683
Autor:
Jessica K. Emelin, Jeffrey E. DeClue, Christopher Kerfoot, Steven N. Roper, Michael Catania, Harry V. Vinters
Publikováno v:
Epilepsy research. 32(1-2)
Cortical dysplasia (CD) broadly defines a complex cerebral malformative lesion associated clinically with intractable, pharmacoresistant epilepsy (including infantile spasms), especially in infants and children. In CD, the spectrum of structural brai
Autor:
David H. Gutmann, John C. Maize, Richard L. Heideman, Ralf Wienecke, Jeffrey E. DeClue, Abhijit Guha
Publikováno v:
Annals of neurology. 42(2)
Individuals affected with tuberous sclerosis complex (TSC) develop several benign and malignant tumors at increased frequency, including astrocytomas. Tuberin, the protein product of the tuberous sclerosis complex-2 (TSC2) tumor suppressor gene, has
Autor:
Jeffrey E. DeClue, Harry V. Vinters, Michael J. De Rosa, Vadims Poukens, Ralf Wienecke, Samuel H. Pepkowitz, Christopher Kerfoot, Sung Hye Park
Publikováno v:
Acta neuropathologica. 94(2)
We report an autopsy case of tuberous sclerosis complex (TSC) in a 20-week gestational age female fetus. The brain showed lesions suggestive of early cortical tubers and subependymal hamartomatous nodules. The large cells within these nodular cluster
Autor:
Cynthia T. Welsh, Ralf Wienecke, John C. Maize, Michael Menchine, Margaret G. Norman, Harry V. Vinters, Jeffrey E. DeClue, Christopher Kerfoot, Jessica K. Emelin
Publikováno v:
Brain pathology (Zurich, Switzerland). 6(4)
Tuberous sclerosis (TSC), an autosomal dominant disorder, is characterized by malformations, hamartomas and tumors in various organs including the brain. TSC is genetically linked to two loci: TSC1 on chromosome 9q34 and TSC2 on 16p13.3. TSC2 has bee