Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Hans M.G. Princen"'
Autor:
Patrick C.N. Rensen, Geurt Stokman, Hans M.G. Princen, Michael Feigh, Marta Iruarrizaga-Lejarreta, José W.A. van der Hoorn, Ditte Denker Thorbekk, John J.P. Kastelein, Sanne Skovgård Veidal, Elsbet J. Pieterman, Lars Verschuren, David A. Fraser, Cristina Alonso, Scott L. Friedman, Brittany Basta, Tore Skjaeret, Anita M. van den Hoek, Jimmy F.P. Berbée
Publikováno v:
Liver International
Liver International, 40(11), 2860-2876. WILEY
Liver International, 40(11), 2860-2876. WILEY
Background & Aims While fibrosis stage predicts liver‐associated mortality, cardiovascular disease (CVD) is still the major overall cause of mortality in patients with NASH. Novel NASH drugs should thus ideally reduce both liver fibrosis and CVD. I
Autor:
Marta Iruarrizaga-Lejarreta, Anita M. van den Hoek, Elsbet J. Pieterman, José W.A. van der Hoorn, Lars Verschuren, David A. Fraser, Tore Skjaeret, Hans M.G. Princen, Cristina Alonso
Publikováno v:
Hepatology Communications, Vol 4, Iss 2, Pp 193-207 (2020)
Hepatology Communications
Hepatology Communications
Icosabutate is a structurally engineered eicosapentaenoic acid derivative under development for nonalcoholic steatohepatitis (NASH). In this study, we investigated the absorption and distribution properties of icosabutate in relation to liver targeti
Autor:
Margareta Behrendt, Arianne van Koppen, Suvi E. Heinonen, Ann-Cathrine Jönsson-Rylander, Anne-Christine Andréasson, Aswin L. Menke, Hans M.G. Princen, Brendan Leighton, Marianne G. Pouwer, Anita M. van den Hoek, J. Wouter Jukema, Elsbet J. Pieterman
Publikováno v:
Journal of Diabetes Research. 2019:1-13
Background. There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase+/− (GK+/
Autor:
Lars Verschuren, Geary W. Olsen, Shu-Ching Chang, Hans M.G. Princen, Marianne G. Pouwer, Elsbet J. Pieterman, J. Wouter Jukema, Martien P. M. Caspers
Publikováno v:
Toxicological Sciences
Toxicological Sciences, 168(2), 519-534. OXFORD UNIV PRESS
Toxicological Sciences, 168(2), 519-534. OXFORD UNIV PRESS
Epidemiological studies have reported positive associations between serum perfluorooctanoic acid (PFOA) and total and non-high-density lipoprotein cholesterol (non-HDL-C) although the magnitude of effect of PFOA on cholesterol lacks consistency. The
Autor:
André Rex, Vincent Prinz, Hans M.G. Princen, Paul Fischer, Matthias Endres, Frieder Schlunk, Dieter Lütjohann, Ulrich Laufs, Marco Foddis
Publikováno v:
Behavioural brain research 396, 112875-(2021). doi:10.1016/j.bbr.2020.112875
Behavioral Brain Research, 396
Behavioral Brain Research, 396
Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PSCK9) neutralizing antibodies effectively lower plasma cholesterol levels and decrease cardiovascular events but also raised some concern that cognitive function could worsen as a side e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57f54470c79c01128abda419148f08a
Autor:
Tsai-Sang Dederichs, Peter Kohl, Katja Krebs, Clinton S. Robbins, Dennis Wolf, Bianca Dufner, Jiadai Zou, E.J. Pieterman, Timo Heidt, Christopher Starz, Rafael Kaeser, Natalie Hoppe, Peter Stachon, Tobias Boettler, Carmen Härdtner, Benoît Ho-Tin-Noé, Hans M.G. Princen, Florian Willecke, Andreas Zirlik, Diana Sharipova, Carolin A. Ehlert, Filip K. Swirski, Constantin von zur Mühlen, Alina Jander, Ingo Hilgendorf, Christoph Bode, Josef Madl, Simon Rauterberg, Jan Kornemann
Publikováno v:
Basic Research in Cardiology
Statins induce plaque regression characterized by reduced macrophage content in humans, but the underlying mechanisms remain speculative. Studying the translational APOE*3-Leiden.CETP mouse model with a humanized lipoprotein metabolism, we find that
Autor:
Brygida Marczyk, Stefan Chlopicki, Agnieszka Jasztal, Anna Bar, Hans M.G. Princen, Anna Kurpińska, Karolina Matyjaszczyk-Gwarda, Elsbet J. Pieterman, Agnieszka Kaczor, Joanna Suraj-Prazmowska, Bartosz Proniewski, Maria Walczak, Zuzanna Majka, Edyta Kuś, Krzysztof Czamara, Anna Kieronska-Rudek
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Long‐term feeding with a high‐fat diet (HFD) induces endothelial dysfunction in mice, but early HFD‐induced effects on endothelium have not been well characterized. Methods and Results Using an magnetic resonance imaging‐based meth
Autor:
André Rex, Vincent Prinz, Dieter Lütjohann, Paul Fischer, Matthias Endres, Marco Foddis, Frieder Schlunk, Ulrich Laufs, Hans M.G. Princen
Publikováno v:
Stroke. 51
Autor:
Elsbet J. Pieterman, Marianne G. Pouwer, Lori L. Jennings, Alain J. van Gool, Jan H.N. Lindeman, Maarten D. Sollewijn Gelpke, Danielle van Keulen, Hans M.G. Princen, Vilmundur Gudnason, Valur Emilsson, Gerard Pasterkamp, Kim Holmstrøm, Ljubica Perisic Matic, Boye Schnack Nielsen, Dennie Tempel, Ulf Hedin
Publikováno v:
PLoS ONE, 14(8). Public Library of Science
Plos One, 8, 14, e0221477
PLoS ONE
PLoS ONE, 14(8). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 14, Iss 8, p e0221477 (2019)
Plos One, 8, 14, e0221477
PLoS ONE
PLoS ONE, 14(8). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 14, Iss 8, p e0221477 (2019)
ObjectivePrevious studies indicate a role for Oncostatin M (OSM) in atherosclerosis and other chronic inflammatory diseases for which inhibitory antibodies are in development. However, to date no intervention studies with OSM have been performed, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9390ed769904473deef47d2afd5dee3
https://dspace.library.uu.nl/handle/1874/390802
https://dspace.library.uu.nl/handle/1874/390802
Autor:
Alex Lopez, Jerome I. Rotter, Yii-Der Ida Chen, Lukas Habegger, Anders Berg Wulff, Richard L Dunbar, John Penn, Anita M. van den Hoek, An Zhao, Omri Gottesman, Cristopher V. Van Hout, Scott M. Damrauer, Tanya M. Teslovich, Aurelie Bouzelmat, Daniel J. Rader, Poulabi Banerjee, David J. Carey, Viktoria Gusarova, Shane McCarthy, Frederick E. Dewey, Kae-Woei Liang, David H. Ledbetter, Gary Herman, Rick Zhang, Alan R. Shuldiner, Svati H. Shah, Claudia Schurmann, Neil Stahl, Marylyn D. Ritchie, Sara Hamon, Colm O'Dushlaine, Ingrid B. Borecki, Daniel A. Gipe, Jesper Gromada, Hans M.G. Princen, Børge G. Nordestgaard, H. Lester Kirchner, Michael F. Murray, Shannon Bruse, Aris Baras, Jeffrey G. Reid, Wayne H-H Sheu, William E. Kraus, Xiuqing Guo, Aeron Small, Brad Shumel, William J. Sasiela, Anne Tybjærg-Hansen, Andrew J. Murphy, Joseph B. Leader, John D. Overton, Robert Pordy, Scott Mellis, Weiping Shao, George D. Yancopoulos, Hayes Dansky, I-Te Lee
Publikováno v:
New England Journal of Medicine. 377:211-221
BackgroundLoss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. It is not kno