Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yate-Ching Yuan"'
Autor:
Kristine L. Witt, Cynthie Wong, Christina T. Teng, Yate-Ching Yuan, Dujin Zhou, M.L. Richard Yip, Menghang Xia, Srilatha Sakamuru, Li-Yu Hsin, Shiuan Chen, Noriko Kanaya
Publikováno v:
Toxicological Sciences. 139:198-209
Endocrine disrupting chemicals (EDCs) interfere with the biosynthesis, metabolism, and functions of steroid hormones, including estrogens and androgens. Aromatase enzyme converts androgen to estrogen. Thus, EDCs against aromatase significantly impact
Autor:
Reiki Nishimura, Makoto Kubo, Charles Warden, Masato Takahashi, Karineh Petrossian, Noriko Kanaya, Zheng Liu, Yate Ching Yuan, Jingjing Ye, Shiuan Chen, Peiguo Chu, Tomofumi Osako, Masayuki Okido, Kazuo Shimada
Publikováno v:
Breast Cancer Research and Treatment. 137:93-107
Aromatase inhibitors (AIs) are important drugs for treating postmenopausal patients with hormone receptor (HR)-positive breast cancer. However, acquired resistance to AI therapies is a significant problem. Our study has revealed that the histone deac
Publikováno v:
Biochemical Pharmacology. 75:1161-1169
Aromatase cytochrome P450 (CYP19) converts androgen to estrogen. In this study, the interactions of four classes of compounds, 17beta-estradiol (the product of aromatase), 17-methyltestosterone (a synthetic androgen), dibenzylfluorescein (a synthetic
Progression or recurrence due to resistance to aromatase inhibitors (AIs) is a significant clinical problem for a considerable number of patients with breast cancer. Programmed cell death 4 (PDCD4), a tumor suppressor protein, is targeted for degrada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadbe830a7afd791e73f9a21b1518d3c
https://europepmc.org/articles/PMC4470793/
https://europepmc.org/articles/PMC4470793/
Aromatase is an estrogen synthetase. Estrogens are female sex hormones involved in the development and growth of breast tumors. It has been of significant interest to elucidate the structure-function relationship of aromatase since its inhibitors hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a50000d903153445a23e8aef55794f1
https://europepmc.org/articles/PMC3253311/
https://europepmc.org/articles/PMC3253311/
Clinical trials have demonstrated the importance of aromatase inhibitor (AI) therapy in the effective treatment of hormone-dependent breast cancers. In contrast to tamoxifen, an antagonist of the estrogen receptor (ER), AIs have shown to be better to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393296dd4ec0abd39a18db1a1c1b4449
https://europepmc.org/articles/PMC2743954/
https://europepmc.org/articles/PMC2743954/
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 102(1-5)
Clinical trials have demonstrated the importance of aromatase inhibitor (AI) therapy in the effective treatment of hormone-dependent breast cancers. Yet, as with all prolonged drug therapy, resistance to aromatase inhibitors does develop. To date, th
Publikováno v:
The Journal of biological chemistry. 279(46)
Estrogen stimulates the proliferation of estrogen receptor (ER)-positive breast cancer cells. Aromatase is the enzyme responsible for the conversion of androgens into estrogens, and synthetic aromatase inhibitors such as letrozole, anastrozole, and e
Autor:
Fangming Zhang, Mark A. Sherman, Yoshio Osawa, Ikuko Kijima, Michael Cho, Dujin Zhou, Yate-Ching Yuan, Elizabeth T. Eng, Yoshiro Toma, Shiuan Chen
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 86(3-5)
The utilization of computer modeling, site-directed mutagenesis, inhibition kinetic analysis and reaction metabolite analysis allows us to better understand the structure-function relationship between aromatase and its inhibitors. Our results have he
Autor:
Yate Ching Yuan, Yasuhiro Miki, Jingjing Ye, Yanyan Hong, Shiuan Chen, Hongzhi Li, Hironobu Sasano, Dean B. Evans
Publikováno v:
PLoS ONE
PLoS ONE, Vol 4, Iss 11, p e8050 (2009)
PLoS ONE, Vol 4, Iss 11, p e8050 (2009)
Immunohistochemistry is one of the most suitable methods for the detection of intratumoral aromatase in order to identify patients who may respond to aromatase inhibitor therapy in hormone-dependent breast cancer. Previous studies showed statisticall