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of 3
pro vyhledávání: '"Stanford J, Stewart"'
Autor:
John K. Erban, Kathy D. Miller, Mark D. Pegram, Denise A. Yardley, Elizabeth Tan-Chiu, Seila Liv, Stanford J. Stewart, Hope S. Rugo
Publikováno v:
Journal of Clinical Oncology. 32:TPS671-TPS671
TPS671^ Background: Response to trastuzumab (T)-based chemoimmunotherapy in metastatic breast cancer segregates according to expression of the Fcg receptor, CD16A, allotypes with patients homozygou...
Autor:
Howard A. Burris, Todd M. Bauer, Giuseppe Giaccone, Jan Baughman, Seock-Ah Im, Hua Li, Stanford J. Stewart, Jane B. Trepel, David A Carlin, Jeffrey L. Nordstrom, Yung-Jue Bang
Publikováno v:
Journal of Clinical Oncology. 31:3004-3004
3004 Background: The anti-HER2 MAb, trastuzumab (H), has proven effective for HER2+ breast cancer (BC) and gastroesophageal cancer (GEC). H’s mechanism of action is incompletely understood, but evidence indicates ADCC is important. MGAH22 is an Fc-
Autor:
Wenjun Zhang, Paul A. Moore, Sergey Gorlatov, Yinhua Yang, Valentina Ciccarone, Tengfei Zhang, Jeffrey L. Nordstrom, Hua Li, Ezio Bonvini, Ling Huang, Jeffrey B. Stavenhagen, Syd Johnson, Stanford J Stewart, Scott Koenig, Steve Burke
Publikováno v:
Breast Cancer Research : BCR
Introduction Response to trastuzumab in metastatic breast cancer correlates with expression of the high binding variant (158V) of the activating Fcγ receptor IIIA (CD16A). We engineered MGAH22, a chimeric anti-HER2 monoclonal antibody with specifici