Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mary C. Olmstead"'
Autor:
Edmund Ong, Lihua Xue, Mary C. Olmstead, Shiwei Steve Liu, Sarah V. Holdridge, Anne Sutherland, Catherine M. Cahill, Claire Magnussen, Patrick Grenier
Publikováno v:
Journal of neuroscience research, vol 100, iss 1
J Neurosci Res
J Neurosci Res
Delta opioid receptor (DOR) agonists alleviate nociceptive behaviors in various chronic pain models, including neuropathic pain, while having minimal effect on sensory thresholds in the absence of injury. The mechanisms underlying nerve injury-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caede4c6afcdd2d117bd498d878a35b1
https://escholarship.org/uc/item/7zc3s2j0
https://escholarship.org/uc/item/7zc3s2j0
Publikováno v:
Behavioural Brain Research. 314:16-20
Both the lateral septum (LS) and anterior hypothalamus (AHA) regulate behavioural defense. We tested whether those two interconnected structures act in serial in that regard. Infusions of the GABAA agonist muscimol into one side of the LS and the con
Publikováno v:
Psychopharmacology. 230:569-577
Impulsive action is mediated through several neurochemical systems, although it is not clear which role each of these plays in the inability to withhold inappropriate responses. Manipulations of the opioid system alter impulsive action in rodents, al
Publikováno v:
Behavioural Pharmacology. 18:767-776
The analgesic effect of opioids is enhanced, and tolerance is attenuated, by ultra-low doses (nanomolar to picomolar) of an opioid antagonist, an effect that is mediated by preventing the receptor from coupling to Gs proteins. Recently, we demonstrat
Publikováno v:
Neuroscience. 135:247-261
Opiates produce analgesia by activating mu opioid receptor-linked inhibitory G protein signaling cascades and related ion channel interactions that suppress cellular activities by hyperpolarization. After chronic opiate exposure, an excitatory effect
Autor:
Asha Jhamandas, Noura S. Abul-Husn, Mary C. Olmstead, Kelly J. Powell, Richard J. Beninger, Khem Jhamandas
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:588-596
Opioid agonists such as morphine have been found to exert excitatory and inhibitory receptor-mediated effects at low and high doses, respectively. Ultra-low doses of opioid antagonists (naloxone and naltrexone), which selectively inhibit the excitato
Publikováno v:
British Journal of Pharmacology
© 2014 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. Background and Purpose The δ opioid receptor (DOP receptor) undergoes internalization both constitutively and i
Autor:
Carmen Chow, Megan K. Mahoney, Scott J. Hayton, Mary C. Olmstead, Katia Befort, Brigitte L. Kieffer
Publikováno v:
Psychopharmacology. 214(4)
Response inhibition, a primary symptom of many psychiatric disorders, is mediated through a complex neuropharmacological network that involves dopamine, serotonin, glutamate, noradrenaline, and cannabinoid mechanisms. Recently, we identified an opioi
Publikováno v:
Opiate Receptors and Antagonists ISBN: 9781588298812
Ultra-low-dose opioid antagonist cotreatment was first shown parad oxically to enhance opioid analgesia and to reduce analgesic tolerance and physical dependence. In this chapter, we review data demonstrating that ultra-low-dose naloxone or naltrexon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::373782109ec5a9256c5dc613811edfea
https://doi.org/10.1007/978-1-59745-197-0_13
https://doi.org/10.1007/978-1-59745-197-0_13
Publikováno v:
PLoS ONE
PLoS ONE, Vol 4, Iss 2, p e4410 (2009)
PLoS ONE, Public Library of Science, 2009, 4 (2), pp.e4410. ⟨10.1371/journal.pone.0004410⟩
PLoS ONE, 2009, 4 (2), pp.e4410. ⟨10.1371/journal.pone.0004410⟩
PLoS ONE, Vol 4, Iss 2, p e4410 (2009)
PLoS ONE, Public Library of Science, 2009, 4 (2), pp.e4410. ⟨10.1371/journal.pone.0004410⟩
PLoS ONE, 2009, 4 (2), pp.e4410. ⟨10.1371/journal.pone.0004410⟩
International audience; Impulsivity is a primary feature of many psychiatric disorders, most notably attention deficit hyperactivity disorder and drug addiction. Impulsivity includes a number of processes such as the inability to delay gratification,