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pro vyhledávání: '"Joel R. Walker"'
Autor:
Margaret Clagett-Dame, Robert W. Curley, Kathryn R. Cavanaugh, Joel R. Walker, Sureshbabu Narayanasamy
Publikováno v:
Journal of Carbohydrate Chemistry. 35:249-260
Improvements in the synthesis of carbon-linked glucuronide/glucoside conjugates of cancer chemopreventive retinoids have been achieved starting with 2,3,4,6-tetra-O-benzyl-D-glucopyranose. The revised approach demonstrates better yields, eliminates t
Autor:
Jamie M. Ahrens, Robert W. Curley, Margaret Clagett-Dame, Joel R. Walker, Hussein Abou-Issa, Nirca J. Nieves, Galal A. Alshafie
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:3038-3048
All-trans retinoic acid analogues such as N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventive and chemotherapeutic agents but their utility has been hampered by dose-limiting side effects. The glucuronide derivatives of 4-HPR, the oxy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2447-2450
Retinoic acid analogues such as N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventatives and chemotherapeutics for numerous types of cancer. The C-linked analogue of the O-glucuronide of 4-HPR (4-HPRCG) has been shown to be a more effec