Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zezhou Wang"'
Albumin and Fibrinogen Combined Prognostic Grade Predicts Prognosis of Patients with Prostate Cancer
Autor:
Xiaofei Wen, Yanqing Wang, Jianjun Sha, Jiahua Pan, Fan Xu, Yong Cai, Chuanyi Hu, Liancheng Fan, Wei Chen, Baijun Dong, Yinjie Zhu, Zezhou Wang, Xun Shangguan, Xiaoguang Shao, Wei Xue, Qiang Liu
Publikováno v:
Journal of Cancer
Background: The nutritional status and systemic inflammation are thought to be associated with outcome in multiple types of cancer. The objective of this study was to determine the prognostic value of pretreatment albumin and fibrinogen combined prog
A Phase I Study of the Metal Ionophore Clioquinol in Patients With Advanced Hematologic Malignancies
Autor:
Jian Chen, Andre C. Schuh, Christine I. Chen, Zezhou Wang, Mark D. Minden, Aaron D. Schimmer, Yulia Jitkova, Sharon Keays, Tristan Booth, Suzanne Ackloo, Joseph Brandwein, Karen W.L. Yee, Vikas Gupta, Marcela Gronda
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 12:330-336
Clioquinol is a small-molecule metal ionophore that inhibits the proteasome through a metal-dependent mechanism. Here, we report a phase I study of clioquinol in patients with refractory hematologic malignancies. Neuropathy and abdominal pain were do
Publikováno v:
Tetrahedron. 65:2643-2648
Several alkynyl epoxides and one alkynyl allyl alcohol were isomerized to cyclic allyl vinyl ethers (3,4-dihydro-2H-1,4-oxazines) using PtCl2 as the catalyst. Three of these allyl vinyl ethers were converted to 2-hydroxymorpholine derivatives by hydr
Autor:
David O'Neill, Amy M. Ruschak, Aaron D. Schimmer, Suzanne Trudel, Rose Hurren, Zhihua Li, Aisha Shamas-Din, Ahmed Aman, Rima Al-awar, Xioaming Wang, Lewis E. Kay, Zezhou Wang, Malik Slassi, Barry Press, Peter Dove, Carly Griffin, A Nachman, Y J Oh, S Climie, Elijus Undzys
Publikováno v:
Cell Death & Disease
Approved proteasome inhibitors have advanced the treatment of multiple myeloma but are associated with serious toxicities, poor pharmacokinetics, and most with the inconvenience of intravenous administration. We therefore sought to identify novel ora
Autor:
Malik Slassi, Jaehyun Choi, Aaron D. Schimmer, Zezhou Wang, Robert A. Uger, Chunlei Wang, Penka S. Petrova
Publikováno v:
Blood. 128:4719-4719
Small molecule inhibitors of the bromodomain and extraterminal domain (BET) proteins are being actively tested in clinical trials for many cancers, but patient selection strategies remain poorly defined. We have previously demonstrated TTI-281 is an
Autor:
Shiyue Fang, Zezhou Wang
Publikováno v:
ChemInform. 41
Several simple bismuth(III) salts were screened for the suitability to catalyze the cycloisomerization of enynes. Among them, BiCl3 gave the best results. Under the optimized reaction conditions, eight substrates were studied, and acceptable to excel
Autor:
Zezhou Wang, Peter Dove, Xiaoming Wang, Carolyn A. Goard, Zhihua Li, Alex Nachman, Yoonsun Jenny Oh, Rose Hurren, Amy Ruschak, Shane Climie, David O'Neill, Barry Press, Carly Griffin, Elijus Undzys, Ahmed Aman, Rima Al-awar, Lewis Kay, Suzanne Trudel, Malik Slassi, Aaron Schimmer
Publikováno v:
Blood. 122:1988-1988
Proteasome inhibitors (PIs), such as bortezomib and carfilzomib, are often associated with serious toxicities, poor pharmacokinetics (PK), and the inconvenience of intravenous administration. Therefore, there is a need for safer and more effective or