Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zawia, A"'
Autor:
Syed Waseem Bihaqi, Reem Deeb, Asma Lahouel, Gehad M. Subaiea, Joanna K Chang, A. Masoud, Nasser H. Zawia, Miriam Dash, Aseel Eid, Foqia Mushtaq, Allison Leso
Publikováno v:
Current Alzheimer Research. 15:655-663
Background: Tangles are deposits of hyperphosphorylated tau, which are found in multiple neurodegenerative disorders that are referred to as tauopathies, of which Alzheimer's disease (AD) is the most common. Tauopathies are clinically characterized b
Autor:
Nasser H. Zawia, Jaunetta Hill
Publikováno v:
Cells, Vol 10, Iss 702, p 702 (2021)
Cells
Cells
Neurodegenerative disorders are desperately lacking treatment options. It is imperative that drug repurposing be considered in the fight against neurodegenerative diseases. Fenamates have been studied for efficacy in treating several neurodegenerativ
Autor:
Nasser H. Zawia, Syed Waseem Bihaqi, Anwar Masoud, Allison Leso, Joanna K Chang, Asma Lahouel
Publikováno v:
Exp Biol Med (Maywood)
In the healthy human brain, the protein tau serves the essential function of stabilizing microtubules. However, in a diseased state, tau becomes destabilized and aggregates into a pathogenic form that ultimately creates one of the two major hallmarks
Publikováno v:
Archives of Oral Biology. 67:54-60
Tricyclic antidepressants (TCA) are well-known xerogenic drugs, while antidepressants such as selective serotonin reuptake inhibitors (SSRI) are considered less xerogenic. The antimuscarinic effect of the TCAs has been considered to be the principal
Publikováno v:
Libyan International Medical University Journal, Vol 1, Iss 1, Pp 17-26 (2016)
Introduction : Tricyclic antidepressant have been shown to be effective in treatment of pain of varying etiology, monoaminergic system seems to be implicated in this phenomena. This research examines the role of beta-adrenergic receptor blockers on t
Publikováno v:
Journal of Neurochemistry. 133:266-272
Tau and its aggregates are linked to the pathology of Alzheimer's disease (AD) and other tauopathies and, therefore, are explored as therapeutic targets for such disorders. Tau belongs to a family of microtubule-associated proteins that promote micro
Publikováno v:
Current Alzheimer Research. 8:860-867
Evidence from our laboratory suggests that tolfenamic acid has a potential for slowing the progression of Alzheimer's disease (AD) through lowering cortical levels of the β-amyloid precursor protein (APP) and its pathogenic amyloid beta (Aβ) interm
Publikováno v:
Current Alzheimer Research. 8:385-392
Amyloid beta (Aβ) peptides are related to the pathogenesis of Alzheimers disease (AD). The search for therapeutic strategies that lower these peptides has mainly focused on the proteolytic processing of the β-amyloid precursor protein (APP), and ot
Autor:
Daniel J. Abrams, Jun J. Yang, Nasser H. Zawia, Karen E. Stevens, Wei Wei, Kevin S. Choo, Lijun Zheng, Thomas J. Anchordoquy
Publikováno v:
Schizophrenia Research. 100:86-96
While clozapine is the acknowledged superior pharmacotherapeutic for the treatment of schizophrenia, the side effect profile, which includes potentially fatal complications, limits its usefulness. Central administration of clozapine directly into the
Publikováno v:
Journal of Alzheimer's disease : JAD. 43(2)
We have previously reported that tolfenamic acid treatment decreases the amyloidogenic proteins in C57BL/6 and in old hemizygous R1.40 transgenic mice via the degradation of the transcription factor specificity 1 protein (Sp1). The lowering of amyloi