Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Stephen R. Bloom"'
Autor:
Wanling Song, Alejandra Tomas, Ben Jones, Tricia Tan, T. B. Ansell, Mark S.P. Sansom, Emma Rose McGlone, David Carling, Stephen R. Bloom, C. Dunsterville
Publikováno v:
Molecular metabolism. 63
Objective To determine whether glucagon receptor (GCGR) actions are modulated by cellular cholesterol levels. Methods We determined the effects of experimental cholesterol depletion and loading on glucagon-mediated cAMP production, ligand internalisa
Autor:
Stavroula Bitsi, Roxana-Maria Rujan, Stephen R. Bloom, Giuseppe Deganutti, Ben Jones, Ivan R. Corrêa, Phil Pickford, James Minnion, Fiona B. Ashford, Emma Rose McGlone, Bryn M. Owen, Alejandra Tomas, David J. Hodson, Tricia Tan, Christopher A. Reynolds, Maria Lucey
ObjectiveGlucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study we investigated the cellular and metabolic effects of modulating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a70cb7d87a7f1ed3ed02cb09c1f0a4
https://doi.org/10.1101/2021.03.02.433157
https://doi.org/10.1101/2021.03.02.433157
Autor:
Madhawi Aldhwayan, Stephen R. Bloom, Werd Al-Najim, Belén Pérez-Pevida, Aviva Petrie, Omar A. Khan, Ahmed R. Ahmed, Veronica Greener, Barbara McGowan, Alexander D. Miras, Harvinder Chahal, Samantha Scholtz, Tricia Tan, Anna Kamocka, Emma Rose McGlone, Rachel L. Batterham
Publikováno v:
The Lancet Diabetes & Endocrinology. 7:549-559
Summary Background Many patients with type 2 diabetes do not achieve sustained diabetes remission after metabolic (bariatric) surgery for the treatment of obesity. Liraglutide, a glucagon-like peptide-1 analogue, improves glycaemic control and reduce
Autor:
Maria Lucey, Stavroula Bitsi, Alejandra Tomas, David J. Hodson, Roxana-Maria Rujan, Ivan R. Corrêa, Giuseppe Deganutti, Christopher A. Reynolds, Fiona B. Ashford, Emma Rose McGlone, Stephen R. Bloom, Phil Pickford, Tricia Tan, James Minnion, Ben Jones, Bryn M. Owen
Publikováno v:
Molecular Metabolism, Vol 51, Iss, Pp 101242-(2021)
Molecular Metabolism
Molecular Metabolism
Objective Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating th
Autor:
Stephen R. Bloom, Ben Jones
Publikováno v:
Drugs
There is an urgent need for effective pharmacological therapies to help tackle the growing obesity epidemic and the healthcare crisis it poses. The past 3 years have seen approval of a number of novel anti-obesity drugs. The majority of these influen
Autor:
Richard G. Kay, Ben Jones, Jaimini Cegla, Colin S. Creaser, Stephen R. Bloom, James W Howard, Tricia Tan
Publikováno v:
Annals of clinical biochemistry. 54(2)
Background One of the main challenges in the measurement of glucagon is the premise that it is unstable in human plasma. Traditionally, protease inhibitors have been used to prevent its degradation; however, their use is controversial. Here, we inves
Publikováno v:
Expert Review of Clinical Pharmacology. 6:171-183
Type 2 diabetes and obesity are intimately linked; reduction of bodyweight improves glycemic control, mortality and morbidity. Treating obesity in the diabetic is hampered as some diabetic treatments lead to weight gain. Bariatric surgery is currentl
Autor:
Peter S. Whitton, Amjad Abuirmeileh, Nazir Rampersaud, Rebecca Lever, John Tadross, Alexander Harkavyi, Stephen R. Bloom
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:637-643
Objectives To determine whether the glucagon-like 1 peptide analogue exendin-4 (EX-4) augments the neurochemical effects of a single L-DOPA treatment and whether EX-4 can decrease L-DOPA induced dyskinesias (LIDS). Methods Rats were lesioned with 6-h
Autor:
Heather E. Ford, Stephen R. Bloom, Aileen King, Bo Liu, Lucy Brooks, Shanta J. Persaud, Amir H Sam, Klara Hostomska, Mohammad A. Ghatei, Gavin A. Bewick, David Jl Gunner
Publikováno v:
Gastroenterology
Gastroenterology; Vol 143
Gastroenterology; Vol 143
Background & Aims In the pancreas, peptide YY (PYY) is expressed by a subpopulation of nonbeta cells in the islets of Langerhans. We investigated the function of these cells in the pancreas of adult mice. Methods We generated mice in which administra
Publikováno v:
Expert Review of Endocrinology & Metabolism. 6:563-577
Despite the requirement for effective and safe pharmacotherapies to tackle the obesity epidemic, there is currently only one drug, orlistat, licensed for this purpose, but the effectiveness of this drug falls far short of the medical needs. Recent ad