Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ryo, Ito"'
Publikováno v:
Biochemical and Biophysical Research Communications. 489:21-28
CYP11B2 is a key enzyme involved in the synthesis of the mineralocorticoid aldosterone. CYP11B2 expression in the adrenal glands is controlled by the renin-angiotensin system (RAS), and plays an important role in the maintenance of electrolyte metabo
Autor:
Mitsugi Ookawara, Koji Takeuchi, Yusuke Moritoh, Hitomi Ogino, Tomoki Yoshihara, Masanori Watanabe, Shin-ichi Abe, Yoshimasa Ishimura, Ryo Ito, Yoshiyuki Tsujihata, Hirohisa Miyashita, Yasufumi Miyamoto, Nobuhiro Nishigaki, Hikaru Ueno, Yukio Yamada
Publikováno v:
Diabetes. 68
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic islets and enteroendocrine cells. SCO-267 is a novel full agonist of GPR40 being developed as a treatment for type 2 diabetes and obesity. The efficacy of SCO-267 was investigated in
Autor:
Gen Kawaguchi, Yuichiro Yoneoka, Yohei Ikeda, Toshinori Takada, Michi Kobayashi, Nobumasa Ohara, Kazumasa Ohashi, Go Hasegawa, Ryo Ito
Publikováno v:
Journal of Medical Case Reports
Journal of Medical Case Reports, Vol 13, Iss 1, Pp 1-10 (2019)
Journal of Medical Case Reports, Vol 13, Iss 1, Pp 1-10 (2019)
Introduction Immune checkpoint inhibitors are a promising class of anticancer drugs. The clinical benefits afforded by immune checkpoint inhibitors can be accompanied by immune-related adverse events that affect multiple organs, and endocrine immune-
Autor:
Toshiyuki Koya, Yoshiro Endo, Yosuke Kimura, Ryo Ito, Toshiaki Kikuchi, Yoshiki Hayashi, Toshihiro Kazawa, Satoshi Watanabe, Akira Iwashima, Yasuyoshi Ohshima
Publikováno v:
Respiratory Medicine Case Reports, Vol 33, Iss, Pp 101451-(2021)
Respiratory Medicine Case Reports
Respiratory Medicine Case Reports
A 70-year-old man, treated for asthma for 2 years and chronic sinusitis for several months, presented with fever, numbness in the lower limbs, heaviness in the head, gross hematuria, and black stools. He also had eosinophilia, elevated serum IgG4 lev
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 357:217-227
Sulfonylureas (SUs) are widely used insulin secretagogues, but they have adverse effects including hypoglycemia and secondary failure. Fasiglifam/TAK-875, a selective GPR40 agonist, enhances glucose-stimulated insulin secretion and improves hyperglyc
Publikováno v:
British Journal of Pharmacology. 170:568-580
Background and Purpose TAK-875, a selective GPCR40/free fatty acid receptor 1 agonist, improves glycaemic control by increasing glucose-dependent insulin secretion. Metformin is a first-line drug for treatment of type 2 diabetes that improves periphe
Autor:
Hiroya Takeuchi, Takahiro Igarashi, Rieko Nakamura, Yuko Kitagawa, Tsunehiro Takahashi, Shinichi Tsuwano, Ryo Ito, Yoshirou Saikawa, Koshi Kumagai, Kazumasa Fukuda
Publikováno v:
International Journal of Clinical Oncology. 14:372-375
A 68-year-old woman presented with severe bowel obstruction and was subsequently diagnosed with stage IV gastric cancer with peritoneal dissemination. She was immediately stabilized in the hospital with the placement of a nasointestinal tube. Abdomin
Autor:
Atsushi Yokoyama, Masataka Kudo, Kaori Sugawara, Sadayoshi Ito, Masahiro Nezu, William E. Rainey, Yuko Iki, Akiko Saito-Hakoda, Fumitoshi Satoh, Ryo Ito, Kyoko Shimizu, Akira Sugawara, Ken Matsuda, Ikuko Sato, Naotaka Kogure, Hiroki Shimada, Takeo Yoshikawa, Akira Uruno, Takako Saito-Ito
Publikováno v:
Molecular and cellular endocrinology. 383(1-2)
We generated a stable H295R cell line expressing aldosterone synthase gene (CYP11B2) promoter/luciferase chimeric reporter construct that is highly sensitive to angiotensin II (AII) and potassium, and defined AII receptor blocker (ARB) effects. In th
Autor:
Tomohiro Maegawa, Kei Nozaki, Ryo Ito, Yasunari Monguchi, Mariko Ina, Yuki Fujita, Hironao Sajiki, Tohru Takahashi, Shota Hashimoto
Publikováno v:
ChemInform. 43
Solvent-free Pd—C-catalyzed hydrogenation of a diversity of reducible functionalities, e.g. benzyl ethers and esters, multiple C—C bonds, alcohols, aromatic chloride, N-Cbz, nitro, and azido groups, is presented.
Autor:
Yuko Iki, Kyoko Shimizu, Sadayoshi Ito, Akira Sugawara, Masataka Kudo, Akiko Saito-Hakoda, Takeo Yoshikawa, Ken Matsuda, Atsushi Yokoyama, Ryo Ito, Ikuko Sato, Takako Saito-Ito, Naotaka Kogure, Kaori Sugawara, Akira Uruno
Publikováno v:
World Journal of Hypertension. 4:7
ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells