Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lorna Rodriguez-Rodriguez"'
Autor:
Thanh H. Dellinger, Mustafa Raoof, Michael P. O'Leary, Adrian Kohut, Yuman Fong, Michael Lew, Andrew M. Blakely, Joseph Chao, Paul Frankel, Amit Merchea, Dean Lim, Marc A. Reymond, Yanghee Woo, Marwan Fakih, Isaac Benjamin Paz, Mihaela C. Cristea, Lorna Rodriguez-Rodriguez, Thuy B. Tran, Gautam Malhotra, Richard L. Whelan
Publikováno v:
Annals of Surgical Oncology. 29:175-185
Peritoneal metastases (PM) from ovarian, gastric, appendiceal, or colorectal origin can be treated via cytoreductive surgery with or without the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) for selected patients. Unfortunately, not a
Autor:
Nora Ruel, Peter P. Lee, Daniel Schmolze, W Guo, Mark T. Wakabayashi, Xiwei Wu, Lorna Rodriguez-Rodriguez, Mehdi Kebria, Mihaela C. Cristea, Mustafa Raoof, Thanh H. Dellinger, Hyejin Cho, Daphne Stewart, Winnie S. Liang, Amy Hakim, Wei-Chien Lin, Ting-Fang He, Byrne Lee, Ernest S. Han, Edward Wang, Marianne Razavi, Stephen J. Lee
Publikováno v:
Poster.
Background Immunogenic cell death has been suggested as a mechanism for HIPEC, through the release of heat shock proteins, and resulting in activation of tumor-specific T cells. Methods This is a subgroup analysis of a Phase I trial using HIPEC with
Autor:
Jyoti Malhotra, Tracie Saunders, Anshuman Panda, Jeffrey S. Ross, Sherri Damare, Greg Riedlinger, Eileen White, Michael P. Kane, Janice M. Mehnert, Howard L. Kaufman, Joseph Aisner, Lorna Rodriguez-Rodriguez, Gyan Bhanot, Kim M. Hirshfield, Shridar Ganesan, Melissa Frankel, Elizabeth Poplin, Siraj M. Ali, Ann W. Silk, Mark N. Stein, Nancy Chan, Levi Sokol
Publikováno v:
JNCI: Journal of the National Cancer Institute. 110:316-320
Response to immune checkpoint therapy can be associated with a high mutation burden, but other mechanisms are also likely to be important. We identified a patient with metastatic gastric cancer with meaningful clinical benefit from treatment with the
Autor:
Levi Sokol, Kim M. Hirshfield, Chandrika Jeyamohan, Srilatha Simhadri, Janice M. Mehnert, Lorna Rodriguez-Rodriguez, Husam Al-Hraishawi, Shridar Ganesan, Sharon R. Pine, Atul Kulkarni, Suzie Chen, Man Lung Teo, Eileen White, Siraj M. Ali
Publikováno v:
Clinical Cancer Research. 23:5631-5638
Purpose: Many patients with BRAFV600E mutant melanoma treated with BRAF inhibitors experience a rapid response, but ultimately develop resistance. Insight into the mechanism of resistance is critical for development of more effective treatment strate
Autor:
Lorna Rodriguez-Rodriguez, Wilberto Nieves-Neira, Darlene Gibbon, Allison Wagreich, Bernadette Cracchiolo, Mihae Song, Robert S. DiPaola, Ami Vaidya, Weichung Joe Shih, Mira Hellmann
Publikováno v:
International Journal of Gynecological Cancer. 24:1636-1641
Objective Overexpression of bcl-2 is a mechanism of drug resistance in cervical cancer. Agents that down-regulate bcl-2 may decrease tumor cell threshold and sensitize tumor cells to chemotherapy. The objective of this multi-institutional phase 2 tri
Next Generation Sequencing As an Aid to Diagnosis and Treatment of an Unusual Pediatric Brain Cancer
Autor:
Rachana Tyagi, John Glod, Robert S. DiPaola, Lorna Rodriguez-Rodriguez, Roy H. Rhodes, David Weissmann, Shridar Ganesan, Sudipta Roychowdhury, Michael P. Kane, Mihae Song, Kim M. Hirshfield, Archana Sharma, Atif J. Khan
Publikováno v:
Journal of Personalized Medicine, Vol 4, Iss 3, Pp 402-411 (2014)
Journal of Personalized Medicine
Journal of Personalized Medicine
Classification of pediatric brain tumors with unusual histologic and clinical features may be a diagnostic challenge to the pathologist. We present a case of a 12-year-old girl with a primary intracranial tumor. The tumor classification was not certa
Publikováno v:
Nanomedicine. 7:185-197
Aims: To develop an approach for the effective treatment of ovarian tumor, prevention of metastases and limitation of side effects. Materials & Methods: In order to combine chemotherapy with genotherapy, we constructed a nanoscale-based tumor-targete
Publikováno v:
Pharmaceutical Research. 27:2296-2306
In order to improve drug delivery to drug-resistant ovarian tumors, we constructed a multifunctional polymer-peptide-drug conjugate (PPDC) system for effective treatment of primary and metastatic ovarian cancers.The PPDC consists of the poly(Ethylene
Autor:
Jatinder Dhami, Shridar Ganesan, Lorna Rodriguez-Rodriguez, Gregory M. Riedlinger, Julia A. Elvin, Kim M. Hirshfield, Dean Pavlick, Judith K. Amorosa, Veronica Rojas, Mira Hellmann, Hua Zhong, Siraj M. Ali
Publikováno v:
Cold Spring Harbor Molecular Case Studies
FGFR-TACC fusions, including FGFR3-TACC3, have been identified as potential oncogenic drivers and actionable alterations in a number of different cancer types. The clinical relevance of FGFR3-TACC3 fusions in endometrial cancer has not yet been descr
Publikováno v:
Advanced drug delivery reviews. 65(13-14)
The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffect