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pro vyhledávání: '"Jonathan Pinkney"'
Publikováno v:
Therapeutics and Clinical Risk Management, Vol 2010, Iss default, Pp 401-411 (2010)
Therapeutics and Clinical Risk Management
Therapeutics and Clinical Risk Management
Jonathan Pinkney1, Thomas Fox1, Lakshminarayan Ranganath21Department of Diabetes and Endocrinology, Peninsula College of Medicine and Dentistry, Plymouth, United Kingdom; 2Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool Un
Publikováno v:
Diabetic Medicine. 27:498-515
Polycystic ovary syndrome (PCOS) is a risk factor for Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), but these risks are poorly defined. This study aimed to evaluate the evidence for these risks and whether screening and risk reduc
Publikováno v:
The American Journal of Medicine. 118:45-50
Obesity is a common consequence in patients with tumors of the hypothalamic region and of related treatment in children. Much less information is available on adult patients and long-term survivors. The aims of this study were to estimate the prevale
Autor:
Vidya Mohamed-Ali, Jonathan Pinkney
Publikováno v:
Treatments in Endocrinology. 1:399-410
Insulin-like growth factor-1 (IGF-1) and its receptors share considerable homology with insulin and insulin receptors, and their respective signaling pathways interact at the post receptor level. While the growth hormone (GH)-IGF-1 axis principally r
Autor:
Stephen E. Humphries, Jonathan Pinkney, Vidya Mohamed-Ali, David A. York, Rosaire Gray, Louise Flower, Jaswinder K. Sethi, Gökhan S. Hotamisligil
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:5864-5869
Circulating IL-6 levels are elevated in obesity. Although IL-6 is expressed in adipose tissue, neither its regulation nor cell of origin is well characterized. Here we investigated the beta-adrenergic regulation of IL-6 release in a combination of st
Autor:
Colin H. Bolton, Leonie G. Downs, Jason G.G. Victory, Charles R.V. Tomson, Jeremy F. Dwight, Michael I. Mackness, Jonathan Pinkney
Publikováno v:
Nephrology Dialysis Transplantation. 16:1189-1197
Background. Chronic renal failure (CRF) is associated with an increased risk of ischaemic heart disease (IHD), but the mechanisms responsible are controversial. We investigated the relationship of two sets of candidate mechanisms-indices of LDL oxida
Publikováno v:
Obesity reviews : an official journal of the International Association for the Study of Obesity. 7(2)
There is a growing worldwide epidemic of obesity. Obese people have a higher incidence of type 2 diabetes and cardiovascular disease, and hence present increasing social, financial and health burdens. Weight loss is always difficult to achieve throug
Autor:
Stafford L. Lightman, JR Katz, Simon W. Coppack, Vidya Mohamed-Ali, S Medbak, Jonathan Pinkney, S Goodrick, Andrew Johnson
Publikováno v:
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 24
Objectives: To determine the dependence of plasma leptin concentrations upon circulating noradrenaline (NA) and thyroid hormones (TH) in humans. Design: Cross-sectional study in 40 newly diagnosed untreated patients with primary thyroid disease, and
Publikováno v:
Diabetologia. 38(4)
The determinants of left ventricular mass in normal control subjects and subjects with non-insulin-dependent diabetes (NIDDM) are ill-defined. We therefore recorded M-mode and pulsed Doppler echocardiograms and 24-h ambulatory blood pressure in 57 no
Publikováno v:
International Journal of Obesity. 24:S154-S155
Objectives: To investigate the effects of β-adrenergic stimulation on IL-6 secretion in humans, and to determine the potential contribution to this response of adipocytes and peripheral blood cells (PBC). Design: Experimental study in 8 human volunt