Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Irwin, D"'
Autor:
Tiffany A. Hylkema, Irwin D. Bernstein, Jessica A. Pollard, Michael R. Loken, Todd A. Alonzo, Laura Pardo, Alan S. Gamis, Richard Aplenc, Soheil Meshinchi, Lillian Sung, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Rhonda E. Ries, Leela Sarukkai, Katherine Tarlock, Yi-Cheng Wang, Jason Joaquin
Publikováno v:
Clinical Cancer Research. 25:5038-5048
Purpose: KIT mutations (KIT+) are common in core binding factor (CBF) AML and have been associated with varying prognostic significance. We sought to define the functional and clinical significance of distinct KIT mutations in CBF pediatric AML. Expe
Publikováno v:
Blood. 130:2373-2376
On 1 September 2017, the US Food and Drug Administration (FDA) approved gemtuzumab ozogamicin (GO) for the treatment of adults with newly diagnosed CD33+ acute myeloid leukemia and for patients aged ≥2 years with CD33+ acute myeloid leukemia who ha
Publikováno v:
Biological Psychiatry. 79:251-257
Over the last decade, oxytocin (OT) has received focus in numerous studies associating intranasal administration of this peptide with various aspects of human social behavior. These studies in humans are inspired by animal research, especially in rod
Autor:
Ebrahim Haroon, Chunliang Feng, Adriana Lori, Irwin D. Waldman, Elisabeth B. Binder, James K. Rilling
Publikováno v:
Genes, Brain and Behavior. 14:516-525
Intranasal oxytocin (OT) can modulate social-emotional functioning and related brain activity in humans. Consequently, OT has been discussed as a potential treatment for psychiatric disorders involving social behavioral deficits. However, OT effects
Autor:
Alan S. Gamis, Jatinder K. Lamba, Irwin D. Bernstein, Lata Chauhan, Michael R. Loken, Roland B. Walter, Miyoung Shin, Rhonda E. Ries, Yi-Cheng Wang, Richard Aplenc, Soheil Meshinchi, Jessica A. Pollard, Betsy A. Hirsch, Todd A. Alonzo, Susana C. Raimondi
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35(23)
Purpose Gemtuzumab ozogamicin (GO), a CD33-targeted immunoconjugate, is a re-emerging therapy for acute myeloid leukemia (AML). CD33 single nucleotide polymorphism rs12459419 C>T in the splice enhancer region regulates the expression of an alternativ
Publikováno v:
Blood. 119:6198-6208
Although the identification of cancer stem cells as therapeutic targets is now actively being pursued in many human malignancies, the leukemic stem cells in acute myeloid leukemia (AML) are a paradigm of such a strategy. Heterogeneity of these cells
Autor:
Vicky Sandhu, Irwin D. Bernstein, Pamela S. Becker, Megan Othus, Frederick R. Appelbaum, Ian B. Nicoud, Colleen Delaney, Laura Cicconi, Ann Dahlberg, Elihu H. Estey, Filippo Milano
Publikováno v:
The Lancet. Haematology. 3(7)
Summary Background The intensive chemotherapy regimens used to treat acute myeloid leukaemia routinely result in serious infections, largely due to prolonged neutropenia. We investigated the use of non-HLA-matched ex-vivo expanded cord blood progenit
Autor:
Irwin D. Waldman, Michelle M. Martel, Molly A. Nikolas, Joel T. Nigg, Karen H. Friderici, Katherine Jernigan
Publikováno v:
Journal of Abnormal Child Psychology. 39:1-10
Attention-Deficit/Hyperactivity Disorder (ADHD) is a prime candidate for exploration of gene-by-environment interaction (i.e., G × E), particularly in relation to dopamine system genes, due to strong evidence that dopamine systems are dysregulated i
Autor:
Irwin D. Waldman, Courtney A. Ficks
Publikováno v:
Current Psychiatry Reports. 11:387-392
Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder characterized by inattention, impulsivity, and/or hyperactivity in children and adults. Putative environmental risk factors for ADHD include toxin and prenatal smoke exposure
Publikováno v:
Blood. 111:4813-4816
Targeting CD33 or CD45 is currently exploited for immunotherapy of acute myeloid leukemia (AML). Gemtuzumab ozogamicin (GO), an immunoconjugate of an anti-CD33 antibody that facilitates cellular uptake of a toxic calicheamicin-γ1 derivative, induces