Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Amer H. Zureikat, Ibrahim Nassour, David L Bartlett, Annissa Desilva, Lance A. Liotta, Aatur D. Singhi, Virginia Espina, Alessandro Paniccia, Samer AlMasri, Nathan Bahary, Brian A. Boone, Herbert J. Zeh, Patricia Loughran, Michael T. Lotze, Mazen S. Zenati
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 20, Pp 7233-7241 (2021)
Cancer Medicine, Vol 10, Iss 20, Pp 7233-7241 (2021)
Introduction Preoperative autophagy inhibition with hydroxychloroquine (HCQ) in combination with gemcitabine in pancreatic adenocarcinoma (PDAC) has been shown to be safe and effective in inducing a serum biomarker response and increase resection rat
Autor:
Nathan Bahary, Naomi Fei, Rajesh Ramanathan, Melissa E. Hogg, Sijin Wen, Brian A. Boone, Herbert J. Zeh, Amer H. Zureikat, Aatur D. Singhi, Michael T. Lotze
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1822-1829 (2021)
Clinical and Translational Science
Clinical and Translational Science
SMAD4, a tumor suppressor gene, is lost in up to 60%–90% of pancreatic adenocarcinomas (PDAs). Loss of SMAD4 allows tumor progression by upregulating autophagy, a cell survival mechanism that counteracts apoptosis and allows intracellular recycling
Autor:
M.E. Hogg, Brian A. Boone, Kenneth K. Lee, Alessandro Paniccia, Nathan Bahary, Susannah G. Ellsworth, Amer H. Zureikat, Joal D. Beane, David L. Bartlett, Asmita Chopra, Michael T. Lotze, Aatur D. Singhi, Herbert J. Zeh, Adam C. Olson, Jacob C. Hodges, Steve Burton
Publikováno v:
Ann Surg Oncol
BACKGROUND. Neoadjuvant therapy is increasingly used for patients with pancreatic ductal adenocarcinoma (PDAC). It is unknown whether neoadjuvant chemoradiotherapy is more effective than chemotherapy (NCRT vs. NAC). We aim to compare pathological and
Autor:
Jun Huang, Ke Liu, Guido Kroemer, Changfeng Li, Borong Zou, Daolin Tang, Rui Kang, Jiao Liu, Herbert J. Zeh
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2022, 13 (2), pp.483-500. ⟨10.1016/j.jcmgh.2021.09.008⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 483-500 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2022, 13 (2), pp.483-500. ⟨10.1016/j.jcmgh.2021.09.008⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 483-500 (2022)
Background & Aims Pancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is negatively regulated by glutathione peroxidase 4. We studied how trypsin, a ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2672294190e99060699bb76afc1e37a6
https://hal.sorbonne-universite.fr/hal-03549632/file/1-s2.0-S2352345X2100196X-main.pdf
https://hal.sorbonne-universite.fr/hal-03549632/file/1-s2.0-S2352345X2100196X-main.pdf
Autor:
Herbert J. Zeh, Meinrad Gawaz, Jennifer L. Miller-Ocuin, Michael T. Lotze, Xiaoyan Liang, Kira L. Russell, Pranav Murthy, Brian A. Boone, Sebastian Vogel, Patricia Loughran
Publikováno v:
Ann Hematol
Platelets are activated in solid cancers, including pancreatic ductal adenocarcinoma (PDA), a highly aggressive malignancy with a devastating prognosis and limited therapeutic options. The mechanisms by which activated platelets regulate tumor progre
Autor:
Herbert J. Zeh, Ulka Sachdev, Sebastian Vogel, Xiangdong Cui, Pranav Murthy, Michael T. Lotze
Publikováno v:
Biochemical and Biophysical Research Communications. 508:614-619
Platelets play a critical role in the pathophysiology of peripheral arterial disease (PAD). The mechanisms by which muscle ischemia regulates aggregation of platelets are poorly understood. We have recently identified the Nod-like receptor nucleotide
Autor:
Jennifer L. Miller-Ocuin, Michael T. Lotze, Melissa E. Hogg, Allan Tsung, Amer H. Zureikat, Pranav Murthy, Natalie Seiser, David L. Bartlett, Nathan Bahary, Lance A. Liotta, Brian A. Boone, Kenneth K. Lee, Herbert J. Zeh, Daolin Tang, Daniel P. Normolle, Aatur D. Singhi, Virginia Espina, J. Wallis Marsh, Ravi K. Amaravadi
Publikováno v:
Clin Cancer Res
Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxych
Autor:
Virginia Falvello, Nathan Bahary, Herbert J. Zeh, Amer H. Zureikat, Ashika Mani, Mazen S. Zenati, Amr I. Al Abbas, Aatur D. Singhi, Melissa E. Hogg
Publikováno v:
Journal of surgical oncologyREFERENCES.
BACKGROUND AND OBJECTIVES Ampullary adenocarcinoma (AA) is classified by immunohistochemical (IHC) subtypes into intestinal (IN), pancreatobiliary (PB), and ambiguous (AM). The impact of adjuvant therapy on IHC subtype and disease stage is unclear. W
Autor:
Ronald G. Stoller, Karen M. Xu, Kimmen Quan, Steven A. Burton, Dwight E. Heron, Rodney E. Wegner, Mark E. Bernard, Philip A. Sutera, Herbert J. Zeh, Nathan Bahary
Publikováno v:
Practical Radiation Oncology. 8:95-106
Purpose Stereotactic ablative radiation therapy's (SABR's) great conformity and short duration has become an attractive treatment modality. We report a phase 2 clinical trial to evaluate efficacy and safety of induction chemotherapy (ICT) followed by
Autor:
Ahmad Hamad, Aatur D. Singhi, Herbert J. Zeh, Rula Amarin, Nathan Bahary, Kevin McGrath, Amer H. Zureikat
Publikováno v:
Journal of the National Comprehensive Cancer Network. 15:983-988
Overexpression of HER2 protein and amplification of the ERBB2 gene has been observed in various adenocarcinomas, providing a therapeutic target that can be used to extend the survival of a select cohort of patients. Anti-HER2 therapy has been success