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pro vyhledávání: '"Fraser L"'
High fibrinogen gamma ' levels in patient plasma increase clot formation a arterial and venous shear
Publikováno v:
Blood Adv
Blood advances, 5(17), 3468-3477. The American Society of Hematology
Blood advances, 5(17), 3468-3477. The American Society of Hematology
Fibrinogen γ' accounts for 3% to 40% of plasma fibrinogen. Earlier studies indicated that fibrinogen γ' forms altered fibrin clots under static conditions, whereas clinically, altered plasma γ' levels are associated with arterial and venous thromb
Autor:
Fraser L. Macrae, Claire E McKinley, Emma Linton, Polly Bowman, Anita Hill, Sam Quested, Stephen R. Baker, Robert A. S. Ariëns, Barnaby Peacock-Young, Darren J. Newton, Talha Munir, Peter Hillmen, Morag Griffin, Daniel Payne, Deborah Clarke
Publikováno v:
American Journal of Hematology. 95:944-952
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder, characterized by complement-mediated intravascular hemolysis and thrombosis. The increased incidence of PNH-driven thrombosis is still poorly understood, but unlike other thr
Autor:
Khalid M. Naseem, Robert A. S. Ariëns, Rhodri King, Fraser L. Macrae, Katherine J. Kearney, Ramzi A. Ajjan, Christian Tiede, Kerrie A. Smith, Benjamin E. J. Spurgeon, Iain W. Manfield, Ramsah Cheah, Fladia Phoenix, Katie J. Simmons, Darren C. Tomlinson, Nikoletta Pechlivani, Michael J. McPherson
Publikováno v:
Blood. 133:1233-1244
Bleeding complications secondary to surgery, trauma, or coagulation disorders are important causes of morbidity and mortality. Although fibrin sealants are considered to minimize blood loss, this is not widely adopted because of its high cost and/or
Publikováno v:
Seminars in Thrombosis and Hemostasis, 48(02), 174-187. Thieme Medical Publishers
Fibrinogen, one of the most abundant plasma proteins playing a key role in hemostasis, is an important modulator of wound healing and host defense against microbes. In the current review, we address the role of fibrin(ogen) throughout the process of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173f89e4cf72de2d34dd99a5f88b3bfd
Autor:
Fraser L. Collins, Laura R. McCabe, Jonathan D. Schepper, Narayanan Parameswaran, Naiomy Rios-Acre
Publikováno v:
The FASEB Journal. 33
Publikováno v:
Seminars in Thrombosis and Hemostasis, 42(4), 344-355. Thieme Medical Publishers
Fibrinogen ?' is a splice variant of the fibrinogen ?-chain, which leads to a negatively charged extension at the C-terminus of the ?-chain. In fibrinogen, the splice variant appears mainly as a heterodimer with the common ?A chain, as ?A/?' fibrinog
Autor:
Fraser L. Macrae, Helen R. McPherson, Filomena A. Carvalho, Marco M. Domingues, Aliaa Sabban, Nuno C. Santos, Ana Filipa Guedes, Robert A. S. Ariëns, Cédric Duval, Ivo C. Martins
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© 2018 Future Medicine Ltd.
AIM: γ' fibrinogen has been associated with thrombosis. Here the interactions between γ'γ' or γAγA fibrinogen and red blood cells (RBCs), and their role on fibrin clot properties were studied. MATERIALS & METHOD
AIM: γ' fibrinogen has been associated with thrombosis. Here the interactions between γ'γ' or γAγA fibrinogen and red blood cells (RBCs), and their role on fibrin clot properties were studied. MATERIALS & METHOD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c998aec0178f978c97d97ae9a66c0d7e
https://hdl.handle.net/10451/37864
https://hdl.handle.net/10451/37864
Autor:
Fraser L. Macrae, Robert A.S. Ariёns, D. Julian A. Scott, Marc A. Bailey, Katherine I Bridge, Anne Johnson, Helen Philippou
Publikováno v:
Thrombosis Research. 134:723-728
Abdominal Aortic Aneurysm (AAA) involves dilatation of the abdominal aorta, with a natural history of expansion and eventual rupture. We have previously shown that AAA patients form denser clots with smaller pores, which are more resistant to fibrino
Autor:
Marco M. Domingues, Filomena A. Carvalho, Ana Filipa Guedes, Fraser L. Macrae, Helen R. McPherson, Nuno C. Santos, Robert A.S. Ariёns
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nanomedicine: Nanotechnology, Biology and Medicine
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nanomedicine: Nanotechnology, Biology and Medicine
© 2018 Elsevier Inc. All rights reserved.
Plasma fibrinogen includes an alternatively spliced γ-chain variant (γ'), which mainly exists as a heterodimer (γAγ') and has been associated with thrombosis. We tested γAγ' fibrinogen-red blood c
Plasma fibrinogen includes an alternatively spliced γ-chain variant (γ'), which mainly exists as a heterodimer (γAγ') and has been associated with thrombosis. We tested γAγ' fibrinogen-red blood c
Autor:
Ton Lisman, Robert A. S. Ariëns, Robert J. Porte, Jelle Adelmeijer, Greg C. G. Hugenholtz, Sebastiaan E. Dulfer, Fraser L. Macrae
Publikováno v:
Journal of Thrombosis and Haemostasis, 14(5), 1054-1066. Wiley
Essentials Patients with cirrhosis have hemostatic changes, which may contribute to a risk of thrombosis. This in vitro study compares clot formation and structure between patients and healthy subjects. Clot formation is delayed in patients; ultimate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5d848bb478815197559ddbb8f01f66
https://eprints.whiterose.ac.uk/97052/1/Hugenholtz_et_al-2016-Journal_of_Thrombosis_and_Haemostasis.pdf
https://eprints.whiterose.ac.uk/97052/1/Hugenholtz_et_al-2016-Journal_of_Thrombosis_and_Haemostasis.pdf