Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Rachel M. Brignall, David C. Williamson, Andrew Costello, Nicolas Gilbert, Armita Hayatbakhsh, Matthew C. Hulme, E. Kate Kemsley, Ryan E. Mewis, Oliver B. Sutcliffe, Christopher J. Schofield
Publikováno v:
Magnetic Resonance in Chemistry. 61:73-82
Amphetamine and cathinone derivatives are abused recreationally due to the sense of euphoria they provide to the user. Methodologies for the rapid detection of the drug derivative present in a seized sample, or an indication of the drug class, are be
Autor:
Haitao Yang, H. T. Henry Chan, Anthony Tumber, Petra Lukacik, Fernanda Duarte, Martin A. Walsh, Lennart Brewitz, Eidarus Salah, Tobias John, Tika R. Malla, Christopher J. Schofield, Claire Strain-Damerell, Zihe Rao, Pratheesh Maheswaran, C. David Owen
Publikováno v:
Chemical Communications
The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some
Autor:
Gen Li, Xiao-Pan Chen, Yu-Hang Yan, Ji Deng, Jürgen Brem, Christopher J. Schofield, You-Cai Xiao, Kai-Rong Zhu, Guo-Bo Li, Fener Chen, Jun-Lin Yu
Publikováno v:
Chemical Communications (Cambridge, England)
Chiral 3-substituted benzoxaboroles were designed as carbapenemase inhibitors and efficiently synthesised via asymmetric Morita–Baylis–Hillman reaction. Some of the benzoxaboroles were potent inhibitors of clinically relevant carbapenemases and r
Autor:
Victor H. Villar, Lynsey M. Meikle, Sheila Brown, Josephine Bunch, Emily K. Osterweil, Richard J. A. Goodwin, Maya Kamat, RuAngelie Edrada-Ebel, Justin J. J. van der Hooft, Michael J. Ormsby, Alex Dexter, Daniel Walker, Gillian Douce, Nicole Strittmatter, Julia M. Edgar, John G. Swales, Saverio Tardito, Jasper C. Komen, Ryan A. Bragg, Daniel M. Wall, Andrew S. MacDonald, Christopher J. Schofield, Heather Hulme, Stephanie A. Barnes, Richard Burchmore, Simon Milling
Publikováno v:
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, eaax6328, pp. 1-10 . https://doi.org/10.1126/sciadv.aax6328
Science Advances 6 (2020) 11
Science Advances
Science Advances, 6(11)
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, pp. eaax6328 . https://doi.org/10.1126/sciadv.aax6328
Science Advances 6 (2020) 11
Science Advances
Science Advances, 6(11)
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, pp. eaax6328 . https://doi.org/10.1126/sciadv.aax6328
Discovery of novel bacterial metabolites reveals an unprecedented role for the microbiome in gut-brain axis communication.
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identit
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6425116aa951a24b358ad25d9af7f085
https://doi.org/10.1126/sciadv.aax6328
https://doi.org/10.1126/sciadv.aax6328
Publikováno v:
Molecules, Vol 26, Iss 147, p 147 (2021)
Molecules
Volume 26
Issue 1
Molecules
Volume 26
Issue 1
N6-methyladenosine(m6A) is the most abundant modification in mRNA. Studies on proteins that introduce and bind m6A require the efficient synthesis of oligonucleotides containing m6A. We report an improved five-step synthesis of the m6A phosphoramidit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57bb960753e3e98fc8cbb0830231974
https://ora.ox.ac.uk/objects/uuid:7c5adb59-03a2-490a-b191-a78166590dca
https://ora.ox.ac.uk/objects/uuid:7c5adb59-03a2-490a-b191-a78166590dca
Autor:
Yu Nakashima, Alen Krajnc, William D. Figg, Zhihong Zhang, Christopher J. Schofield, James P. Holt-Martyn, Michael A. McDonough, Rasheduzzaman Chowdhury
Publikováno v:
Chemmedchem
Human prolyl‐hydroxylases (PHDs) are hypoxia‐sensing 2‐oxoglutarate (2OG) oxygenases, catalysis by which suppresses the transcription of hypoxia‐inducible factor target genes. PHD inhibition enables the treatment of anaemia/ischaemia‐relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058c383817759f269feac21f85ac833f
https://doi.org/10.1002/cmdc.202100133
https://doi.org/10.1002/cmdc.202100133
Autor:
Oliver B. Sutcliffe, Armita Hayatbakhsh, Andrew Costello, Christopher J. Schofield, Rachel M. Brignall, Nicolas Gilbert, David C. Williamson, E. Kate Kemsley, Matthew C. Hulme, Ryan E. Mewis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b23a51cf4b448ab32fe2aa1ad9fae01
https://doi.org/10.1002/mrc.5156/v2/response1
https://doi.org/10.1002/mrc.5156/v2/response1
Autor:
Christopher W. Foster, Christopher J. Schofield, Lysbeth H. Antonides, Nicolas Gilbert, Craig E. Banks, Loanda R. Cumba, Tarek S. Belal, Hadil M. Elbardisy, Hoda G. Daabees, Wael Talaat, Oliver B. Sutcliffe
Publikováno v:
Analytical Methods. 11:1053-1063
Over recent years there has been a progressive increase in the adulteration of common illicit street drugs, such as heroin and cocaine, with fentanyl and its derivatives (fentalogues) being the cause of over doses ending with fatal repercussions. Con
Autor:
Malcolm G. P. Page, Jürgen Brem, Christopher J. Schofield, Thomas M. Leissing, Pauline A. Lang
Publikováno v:
Antimicrobial Agents and Chemotherapy
β-Lactam antibiotics are presently the most important treatments for infections by pathogenic Escherichia coli, but their use is increasingly compromised by β-lactamases, including the chromosomally encoded class C AmpC serine-β-lactamases (SBLs).
Autor:
Patrick Rabe, Christopher J. Schofield, Yuri Ermolovich, Tharindi D. Panduwawala, Jürgen Brem, Karina Calvopiña, Alistair J. M. Farley, Fredrik Björkling
Publikováno v:
Farley, A J M, Ermolovich, Y, Calvopiña, K, Rabe, P, Panduwawala, T, Brem, J, Björkling, F & Schofield, C J 2021, ' Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates ', ACS Infectious Diseases, vol. 7, no. 6, pp. 1809–1817 . https://doi.org/10.1021/acsinfecdis.1c00104
ACS Infectious Diseases
ACS Infectious Diseases
Metallo-β-lactamases (MBLs) can efficiently catalyze the hydrolysis of all classes of β-lactam antibiotics except monobactams. While serine-β-lactamase (SBL) inhibitors (e.g., clavulanic acid, avibactam) are established for clinical use, no such M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d418daa9999253390b86c6519304f6
https://curis.ku.dk/ws/files/285447738/acsinfecdis.1c00104.pdf
https://curis.ku.dk/ws/files/285447738/acsinfecdis.1c00104.pdf