Zobrazeno 11 - 20
of 79
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Christopher J. Schofield, Paolo Spingardi, Tobias John, Akane Kawamura, Richard J. Hopkinson, Raphael Reinbold
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-5 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-5 (2020)
Metampicillin is a β-lactam antibiotic that is prepared by the reaction of ampicillin with formaldehyde. Although metampicillin has been studied for treatment of infections in animals and humans, its structure has been unclear. We report NMR studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13864a1e9b1dda101e8dc2b737e03f7c
https://ora.ox.ac.uk/objects/uuid:8bd79c2b-d47f-42aa-8c4e-95099aabf873
https://ora.ox.ac.uk/objects/uuid:8bd79c2b-d47f-42aa-8c4e-95099aabf873
Autor:
E. Kate Kemsley, Ryan E. Mewis, Andrew Costello, Nicolas Gilbert, J. Hena Hussain, Christopher J. Schofield, Oliver B. Sutcliffe
Recreational MDMA use is a worldwide problem. Tablet dosage varies, thus entailing a requirement for quantitative analysis. The quantification of MDMA in tablets using benchtop 1H NMR spectroscopy via either linear regression (‘manual’ method) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8a8a2d573d645f1a897adf79dc55c6
https://e-space.mmu.ac.uk/626243/
https://e-space.mmu.ac.uk/626243/
Autor:
Jürgen Brem, Alen Krajnc, Jules Philippe, Tharindi D. Panduwawala, Peteris Trapencieris, Ricky Cain, Christopher J. Schofield, Karina Calvopiña, Thomas M. Leissing, Colin W. G. Fishwick, Pauline A. Lang, Malcolm G. P. Page, Anete Parkova
Publikováno v:
Biomolecules, Vol 10, Iss 899, p 899 (2020)
Biomolecules
Volume 10
Issue 6
Biomolecules
Volume 10
Issue 6
Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as clinically useful, dual-action inhibitors of both serine- (SBL) and metallo- (MBL) β-lactamases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed1fc7cefd4d5f26a643d50d110c359
https://ora.ox.ac.uk/objects/uuid:10f73715-f3da-4f86-8aba-052ec9a131b1
https://ora.ox.ac.uk/objects/uuid:10f73715-f3da-4f86-8aba-052ec9a131b1
Autor:
Haitao Yang, Xiang Liu, Weihong Zhou, Han Wang, Luke W. Guddat, Christopher J. Schofield, Aili Zhang, Zihe Rao, Zuokun Lu, Cheng Yang
Because of β-lactamase–mediated resistance, β-lactam antibiotics were long considered ineffective drugs for tuberculosis (TB) treatment. However, some β-lactams, including meropenem and faropenem, are being re-evaluated in patients infected with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fedcaf708aeff7039577329a57679bf
https://doi.org/10.1124/mol.119.118042
https://doi.org/10.1124/mol.119.118042
Autor:
Opher Gileadi, Hannah T Baddock, J.A. Newman, Yuliana Yosaatmadja, Christopher J. Schofield, Peter J. McHugh
Publikováno v:
DNA Repair
Unrepaired, or misrepaired, DNA damage can contribute to the pathogenesis of a number of conditions, or disease states; thus, DNA damage repair pathways, and the proteins within them, are required for the safeguarding of the genome. Human SNM1A is a
Autor:
Tobias John, Raphael Reinbold, Akane Kawamura, Paolo Spingardi, Richard J. Hopkinson, Christopher J. Schofield, Amber L. Thompson
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports
Scientific Reports
Formaldehyde (HCHO) is a simple and highly reactive human metabolite but its biochemistry is poorly defined. A limiting factor in HCHO research is lack of validated quantification methods for HCHO relevant to biological samples. We describe spectrosc
Autor:
Pauline A. Lang, James Spencer, Philip Hinchliffe, Catherine L. Tooke, Jürgen Brem, Adrian J. Mulholland, Christopher J. Schofield
Publikováno v:
Tooke, C, Hinchliffe, P, Pauline, L, Mulholland, A, Brem, J, Schofield, C J & Spencer, J 2019, ' Molecular Basis of Class A β-lactamase Inhibition by Relebactam ', Antimicrobial Agents and Chemotherapy . https://doi.org/10.1128/AAC.00564-19, https://doi.org/10.1128/AAC.00564-19
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
β-Lactamase production is the major β-lactam resistance mechanism in Gram-negative bacteria. β-Lactamase inhibitors (BLIs) efficacious against serine β-lactamase (SBL) producers, especially strains carrying the widely disseminated class A enzymes
Autor:
Julia Günter, Christina Pickel, Roland H. Wenger, Pascale Sulser, Christopher J. Schofield, Carsten C. Scholz, Thomas M. Leissing, Daniel Crean
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(2)
Pharmacologic HIF hydroxylase inhibitors (HIs) are effective for the treatment of anemia in chronic kidney disease patients and may also be beneficial for the treatment of diseases such as chronic inflammation and ischemia-reperfusion injury. The sel
Autor:
Jürgen Brem, Ricky Cain, Karina Calvopiña, Matthew B. Avison, Kate J. Heesom, Christopher J. Schofield, Samar Johnson, James Spencer, Philip Hinchliffe, Colin W. G. Fishwick, Christopher T. Lohans
Publikováno v:
Molecular Microbiology. 106:492-504
Clavulanic acid and avibactam are clinically deployed serine β-lactamase inhibitors, important as a defence against antibacterial resistance. Bicyclic boronates are recently discovered inhibitors of serine and some metallo β-lactamases. Here, we sh
Autor:
Isabelle Moneke, Roland Schüle, Erik Schleicher, Akane Kawamura, Silke Lassmann, Hanna Tarhonskaya, Dina Robaa, Kuo-Feng Hsu, Martine I. Abboud, Rebecca L. Hancock, Wolfgang Sippl, Henriette Franz, Kerstin Lippl, Christopher J. Schofield, Nicolas P F Barthes, Theresa D. Ahrens, Manfred Jung, Sarah E. Wilkins, Sandra Wenzler, Martin Roatsch, Tzu Lan Yeh, Inga Hoffmann, Sven Diederichs, Kerstin Serrer
Publikováno v:
ACS chemical biology. 14(8)
Fe(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are epigenetic eraser enzymes involved in the regulation of gene expression and are emerging drug targets in oncology. We screened a set of clinica