Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anu, Loukola"'
Autor:
Meghan J. Chenoweth, Nicholas G. Martin, Anu Loukola, Caryn Lerman, Jadwiga Buchwald, Jaakko Kaprio, Teemu Palviainen, Terho Lehtimäki, Veikko Salomaa, Tony P. George, Matti Pirinen, Christian Benner, Richard J. Rose, Gu Zhu, Olli T. Raitakari, Scott Gordon, Rachel F. Tyndale, Samuli Ripatti, Tellervo Korhonen, Pamela A. F. Madden
Publikováno v:
Molecular psychiatry
Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are altered by the rate of nicotine clearance. Nicotine clearance can be estimated using the nicotine metabolite ratio (NMR) (ratio of 3 ' hydroxycotinine/co
Autor:
Daniel F. Gudbjartsson, Daniel W. McNeil, Younghun Han, Jacqueline M. Vink, Michael C. Neale, Christopher I. Amos, Richard Sherva, Laura J. Bierut, Fangyi Gu, Nathan C. Gaddis, Cristie Glasheen, M. T. Landi, Yuelong Guo, Neil E. Caporaso, Lindsay A. Farrer, Eric O. Johnson, Nancy L. Saccone, James McKay, Rayjean J. Hung, Dorret I. Boomsma, John E. Hokanson, Gunnar W Reginsson, Camelia C. Minică, Christina A. Markunas, Jaakko Kaprio, Timothy B. Baker, Kari Stefansson, S. Olson, Dana B. Hancock, Joel Gelernter, Anu Loukola, Mary L. Marazita, Beenish Qaiser, Thorgeir E. Thorgeirsson, Henry R. Kranzler, Kendra A. Young, Sharon M. Lutz, P. A. F. Madden
Publikováno v:
Molecular Psychiatry, 23
Hancock, D B, Guo, Y, Reginsson, G W, Gaddis, N C, Lutz, S M, Sherva, R, Loukola, A, Minica, C C, Markunas, C A, Han, Y, Young, K A, Gudbjartsson, D F, Gu, F, McNeil, D W, Qaiser, B, Glasheen, C, Olson, S, Landi, M T, Madden, P A F, Farrer, L A, Vink, J, Saccone, N L, Neale, M C, Kranzler, H R, McKay, J, Hung, R J, Amos, C I, Marazita, M L, Boomsma, D I, Baker, T B, Gelernter, J, Kaprio, J, Caporaso, N E, Thorgeirsson, T E, Hokanson, J E, Bierut, L J, Stefansson, K & Johnson, E O 2018, ' Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence ', Molecular Psychiatry, vol. 23, no. 9, pp. 1911–1919 . https://doi.org/10.1038/mp.2017.193
Molecular Psychiatry, 23, 9
Molecular Psychiatry, 23(9). Nature Publishing Group
Hancock, D B, Guo, Y, Reginsson, G W, Gaddis, N C, Lutz, S M, Sherva, R, Loukola, A, Minica, C C, Markunas, C A, Han, Y, Young, K A, Gudbjartsson, D F, Gu, F, McNeil, D W, Qaiser, B, Glasheen, C, Olson, S, Landi, M T, Madden, P A F, Farrer, L A, Vink, J, Saccone, N L, Neale, M C, Kranzler, H R, McKay, J, Hung, R J, Amos, C I, Marazita, M L, Boomsma, D I, Baker, T B, Gelernter, J, Kaprio, J, Caporaso, N E, Thorgeirsson, T E, Hokanson, J E, Bierut, L J, Stefansson, K & Johnson, E O 2018, ' Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence ', Molecular Psychiatry, vol. 23, no. 9, pp. 1911–1919 . https://doi.org/10.1038/mp.2017.193
Molecular Psychiatry, 23, 9
Molecular Psychiatry, 23(9). Nature Publishing Group
Item does not contain fulltext Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence var
Autor:
Jenny van Dongen, Tellervo Korhonen, Anu Loukola, Rachel F. Tyndale, Richa Gupta, Yu Fu, Jaakko Kaprio, Dorret I. Boomsma, Vidya Velagapudi, Miina Ollikainen, Abdel Abdellaoui
Publikováno v:
Clinical Epigenetics
Clinical epigenetics, 11(1):1, 1-13. Springer Verlag
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)
Gupta, R, Van Dongen, J, Fu, Y, Abdellaoui, A, Tyndale, R F, Velagapudi, V, Boomsma, D I, Korhonen, T, Kaprio, J, Loukola, A & Ollikainen, M 2019, ' Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci ', Clinical epigenetics, vol. 11, no. 1, 1, pp. 1-13 . https://doi.org/10.1186/s13148-018-0606-9
Clinical epigenetics, 11(1):1, 1-13. Springer Verlag
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)
Gupta, R, Van Dongen, J, Fu, Y, Abdellaoui, A, Tyndale, R F, Velagapudi, V, Boomsma, D I, Korhonen, T, Kaprio, J, Loukola, A & Ollikainen, M 2019, ' Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci ', Clinical epigenetics, vol. 11, no. 1, 1, pp. 1-13 . https://doi.org/10.1186/s13148-018-0606-9
Background DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine levels as a proxy of nicotine
Autor:
Anu Loukola, George Davey Smith, Amy E Taylor, Caroline L Relton, Rebecca C Richmond, Jaakko Kaprio, Teemu Palviainen, Marcus R. Munafò
Publikováno v:
Taylor, A E, Richmond, R C, Palviainen, T, Loukola, A, Wootton, R E, Kaprio, J, Relton, C L, Davey Smith, G & Munafò, M R 2019, ' The effect of body mass index on smoking behaviour and nicotine metabolism : a Mendelian randomization study ', Human Molecular Genetics, vol. 28, no. 8, ddy434, pp. 1322-1330 . https://doi.org/10.1093/hmg/ddy434
Human Molecular Genetics
Human Molecular Genetics
BackgroundGiven clear evidence that smoking lowers weight, it is possible that individuals with higher body mass index (BMI) smoke in order to lose or maintain their weight.Methods and FindingsWe undertook Mendelian randomization analyses using 97 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd29c326b8198c4c25fdb3b02a395642
Autor:
Ida Surakka, Pekka Jousilahti, Jenni Hällfors, Anu Raevuori, Anu Loukola, Pamela A. F. Madden, Richa Gupta, Teemu Palviainen, Jadwiga Buchwald, Samuli Ripatti, Tellervo Korhonen, Jaakko Kaprio
Publikováno v:
Addiction Biology
The heritability of nicotine dependence based on family studies is substantial. Nevertheless, knowledge of the underlying genetic architecture remains meager. Our aim was to identify novel genetic variants responsible for interindividual differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed3eb92fa3e6f9520a6f8e569eeb20e
http://hdl.handle.net/10138/236497
http://hdl.handle.net/10138/236497
Autor:
Miina Ollikainen, Veikko Salomaa, Pamela A. F. Madden, Amanda B Zheutlin, Markus Perola, Sebastian Therman, Tyrone D. Cannon, Anu Loukola, Lili Milani, Samuli Ripatti, Tero Hiekkalinna, Richa Gupta, Liang He, Jaakko Kaprio, Beenish Qaiser, Tellervo Korhonen
Publikováno v:
Translational Psychiatry
Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in schizophrenia, a neurodevelopmental disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed18c3135343b08018b984a8474fbc08
https://erepo.uef.fi/handle/123456789/5212
https://erepo.uef.fi/handle/123456789/5212
Publikováno v:
Current Addiction Reports. 1:75-82
Regular smoking is the major risk factor for cardiovascular disease and cancers, and thus is one of the most preventable causes of morbidity and mortality worldwide. Intake of nicotine, its central nervous system effects, and its metabolism are regul
Autor:
Cristina Menni, Lavinia Paternoster, Alexander I. Stiby, Veikko Salomaa, Jingchun Chen, Rachel F. Tyndale, Leo-Pekka Lyytikäinen, Roseann E. Peterson, Jacqueline M. Vink, Kirsi Auro, Gonneke Willemsen, René Pool, Terho Lehtimäki, Brenda W. J. H. Penninx, Yuri Milaneschi, Dorret I. Boomsma, Xiangning Chen, Mika Kähönen, Markus Perola, Massimo Mangino, Olli T. Raitakari, Seppo Koskinen, Richard J. Rose, Jaakko Kaprio, Juho Wedenoja, Camelia C. Minică, George Davey Smith, Catherine A. Wassenaar, Tim D. Spector, Markku Heliövaara, Tellervo Korhonen, Nicholas J. Timpson, Gibran Hemani, Jouke-Jan Hottenga, Anu Loukola, Andy Z. X. Zhu, Jennifer J. Ware, Marcus R. Munafò
Publikováno v:
Scientific Reports
Ware, J J, Chen, X, Vink, J, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikainen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliovaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Smith, G D, Raitakari, O T, Lehtimaki, T, Kahonen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafo, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6 . https://doi.org/10.1038/srep20092
Ware, J J, Chen, X, Vink, J M, Loukola, A, Minica, C C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, Raitakari, O T, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T D, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, no. 20092, 20092 . https://doi.org/10.1038/srep20092
Scientific Reports, 6(20092):20092. Nature Publishing Group
Ware, J J, Chen, X, Vink, J, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, Raitakari, O T, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, pp. 20092 . https://doi.org/10.1038/srep20092
Ware, J J, Chen, X, Vink, J M, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N J, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, T Raitakari, O, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, 20092 . https://doi.org/10.1038/srep20092
Scientific Reports, 6. Nature Publishing Group
Ware, J J, Chen, X, Vink, J, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikainen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliovaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Smith, G D, Raitakari, O T, Lehtimaki, T, Kahonen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafo, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6 . https://doi.org/10.1038/srep20092
Ware, J J, Chen, X, Vink, J M, Loukola, A, Minica, C C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, Raitakari, O T, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T D, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, no. 20092, 20092 . https://doi.org/10.1038/srep20092
Scientific Reports, 6(20092):20092. Nature Publishing Group
Ware, J J, Chen, X, Vink, J, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, Raitakari, O T, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, pp. 20092 . https://doi.org/10.1038/srep20092
Ware, J J, Chen, X, Vink, J M, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N J, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, T Raitakari, O, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, 20092 . https://doi.org/10.1038/srep20092
Scientific Reports, 6. Nature Publishing Group
Genome-wide association studies (GWAS) of complex behavioural phenotypes such as cigarette smoking typically employ self-report phenotypes. However, precise biomarker phenotypes may afford greater statistical power and identify novel variants. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e87a027dd62b50a34d861fb06837352
http://hdl.handle.net/10138/160992
http://hdl.handle.net/10138/160992
Autor:
Kaisu Keskitalo-Vuokko, Samuli Ripatti, Janne Pitkäniemi, Markus Perola, Veikko Salomaa, Arpo Aromaa, Outi Salminen, Markku Heliövaara, Ulla Broms, Jaakko Kaprio, Anu Loukola
Publikováno v:
Nicotine & Tobacco Research. 13:686-690
Introduction: Genetic effects contribute to individual differ- ences in smoking behavior. Persistence to smoke despite known harmful health effects is mostly driven by nicotine addiction. As the physiological effects of nicotine are mediated by nicot
Autor:
Anu Loukola, Leena Peltonen, James J. McGough, Matthew N. Ogdie, Anja Taanila, Stanley F. Nelson, Sandra K. Loo, Teppo Varilo, Marjo-Riitta Järvelin, Irma Moilanen, Emma S. Nyman, Susan L. Smalley, Tuula Hurtig
Publikováno v:
Journal of the American Academy of Child & Adolescent Psychiatry. 46:1614-1621
Objective Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset disorder with a significant impact on public health. Although a genetic contribution to risk is evident, predisposing genetic determinants remain largely unknown de