Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Albert E. Dahlberg"'
Autor:
Steven Krakowka, Kara Fitzgerald, Ryan G. Rhodes, Sunthorn Pond-Tor, John Mcmichael, Jeffrey L. Osborn, Albert E. Dahlberg, Sarah Beseme, Lloyd Saberski, Stephen W. Mamber, Neal Wright
Publikováno v:
mSphere
mSphere, Vol 5, Iss 3 (2020)
mSphere, Vol 5, Iss 3, p e00288-20 (2020)
mSphere, Vol 5, Iss 3 (2020)
mSphere, Vol 5, Iss 3, p e00288-20 (2020)
Severe acute respiratory syndrome coronavirus 2 (SARS coronavirus 2, or SARS-CoV-2) is the cause of the respiratory infection known as COVID-19. From an immunopathological standpoint, coronaviruses such as SARS-CoV-2 induce increased levels of a vari
Autor:
Frank V. Murphy, Eileen L. Murphy, Jacqueline L. Connetti, Steven T. Gregory, Gerwald Jogl, Hasan DeMirci, Albert E. Dahlberg
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4308-4317
Streptomycin is a bactericidal antibiotic that induces translational errors. It binds to the 30S ribosomal subunit, interacting with ribosomal protein S12 and with 16S rRNA through contacts with the phosphodiester backbone. To explore the structural
Capreomycin susceptibility is increased by TlyA-directed 2′-O-methylation on both ribosomal subunits
Publikováno v:
Molecular Microbiology. 85:1194-1203
The binding site of the cyclic peptide antibiotics capreomycin and viomycin is located on the ribosomal subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. In Mycobacterium tuberculosis, the 2'-hydroxyls of both nucleotide
Autor:
Wipa Chungjatupornchai, Tanakarn Monshupanee, Albert E. Dahlberg, Stephen Douthwaite, Steven T. Gregory
Publikováno v:
Monshupanee, T, Gregory, S T, Douthwaite, S, Chungjatupornchai, W & Dahlberg, A E 2008, ' Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications ', Journal of Bacteriology, vol. 190, no. 23, pp. 7754-7761 . https://doi.org/10.1128/JB.00984-08
Translocation during the elongation phase of protein synthesis involves the relative movement of the 30S and 50S ribosomal subunits. This movement is the target of tuberactinomycin antibiotics. Here, we describe the isolation and characterization of
Publikováno v:
Journal of Molecular Biology. 322:273-279
The oxazolidinone family is a new class of synthetic antibiotics that bind to the bacterial 50S ribosomal subunit. Two members of the family, linezolid and XA043, were examined for their effects on translational fidelity using a lacZ reporter gene in
Publikováno v:
The EMBO Journal. 9:735-739
We have compared the influence of spectinomycin (Spc) on individual partial reactions during the elongation phase of translation in vitro by wild-type and mutant ribosomes. The data show that the antibiotic specifically inhibits the elongation factor
The structural basis for the streptomycin dependence phenotype of ribosomal protein S12 mutants is poorly understood. Here we describe the application of site-directed mutagenesis and gene replacement of Thermus thermophilus rpsL to assess the import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b7ca8242cf516f1fabeb5202414f79
https://europepmc.org/articles/PMC1111998/
https://europepmc.org/articles/PMC1111998/
Publikováno v:
Journal of bacteriology. 187(6)
A spontaneous kanamycin resistance and capreomycin resistance mutation, A1408G, in the decoding center of 16S rRNA, was identified in the extreme thermophile Thermus thermophilus . Unexpectedly, this mutation also confers resistance to streptomycin.
Autor:
Albert E. Dahlberg, Michael O'Connor
Publikováno v:
Current microbiology. 45(6)
Two single-base mutations in 16S rRNA conferring high-level resistance to spectinomycin were isolated on a plasmid-borne copy of the rrnD operon from Salmonella enterica serovar Typhimurium. Neither of the mutations (C1066U and C1192U) had appreciabl
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(23)
Mutations at position 912 of Escherichia coli 16S rRNA result in two notable phenotypes. The C-->U transition confers resistance to streptomycin, a translational-error-inducing antibiotic, while a C-->G transversion causes marked retardation of cell