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Publikováno v:
Materials Today: Proceedings. 80:3318-3321
Air pollution is a global health threat and causes millions of human deaths annually. Outdoor and indoor air pollutants such as polycyclic aromatic hydrocarbons (PAHs) are the most prevalent cause of respiratory disorders, lung disease, pregnancy dis
Autor:
José Realino de Paula, Larissa Córdova Turones, Matheus Gabriel de Oliveira, Lorrane Kelle da Silva Moreira, Aline Nazareth Martins, Dionys de Souza Almeida, Thiago Levi Silva Oliveira, Leonardo Luiz Borges, Vinicius Barreto da Silva, Elson Alves Costa
Publikováno v:
Journal of Traditional and Complementary Medicine. 12:318-329
Background and aim Hibalactone (HB) is a lignan related to the anxiolytic-like effects of Hydrocotyle umbellata L. However, there is a need to understand better the mechanism of action of this lignan to support the ethnopharmacological uses of the sp
Publikováno v:
International Journal of Oral and Maxillofacial Surgery. 51:713-723
Melatonin receptors can inhibit breast and prostate cancers; however, little is known regarding their effects on oral squamous cell carcinoma. In this study, we collected specimens from 81 patients with oral squamous cell carcinoma and analysed clini
Publikováno v:
Cannabis and Cannabinoid Research. 7:188-198
Introduction: Activation of cannabinoid 1 receptors (CB1Rs) by endocannabinoids (eCBs) is controlled by both eCB production and eCB inactivation. Accordingly, inhibition of eCB hydrolyzing enzymes, monoacylglycerol lipase (MAGL) and α/β-hydrolase d
Autor:
Bárbara Arévalo, Verónica García-Castillo, Carlos Pérez-Plasencia, Margarita Gutiérrez, Rebeca Salgado-García, Nelson E. Brown, Alexandra Olate-Briones, Francisco Valdes, Claudio Valenzuela, Angel Cayo
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1414-1425
Background: Adenosine is a natural nucleoside present in a variety of organs and tissues, where it acts as a modulator of diverse physiological and pathophysiological processes. These actions are mediated by at least four G protein-coupled receptors,
Autor:
Parthiban Marimuthu, Thirugnanasambandham Sivasubramanian Anitha, Mugilarasi Purushothaman, Muralidharan A Ramachandran, Daisy S. Precilla, Shreyas S Kuduvalli
Publikováno v:
Current Molecular Pharmacology. 15:338-360
Background: Glioblastoma Multiforme (GBM) is one of the most heterogeneous primary brain tumors with high mortality. In spite of the current therapeutic approaches, the survival rate remains poor, with death occurring within 12 to 15 months after the
Autor:
Mark Jason De Jesus, Mandy Rickard, Jin Kyu Kim, Michael Chua, Joana Dos Santos, Armando J. Lorenzo, Jun S. Dy, Min Joon Lee, Jessica M. Ming
Publikováno v:
Journal of Urology. 207:524-533
ß3-adrenergic receptor agonists (ß3 agonists) have been used in treatment of overactive bladder (OAB) and neurogenic detrusor overactivity (NDO) in adults. However, their use in children has only recently been approved by the U.S. Food and Drug Adm
Autor:
Emily Kessler, Rodrigo Saad-Berreta, Hongwu Zheng, Vikram Deshpande, Krishna S. Tummala, Brandon Nicolay, William Shen, Ramzi Adil, Meng-Ju Wu, Juan Dubrot, Lipika Goyal, Vajira Weeresekara, Amaya Pankaj, Mathias Heikenwalder, Tong Wang, Mirian Fernandez-Vaquero, María García-Beccaria, Ting-Yu Wei, Kira E Olander, Sebastien Ronseaux, Vindhya Vijay, Qibiao Wu, Yuanli Zhen, Christine Hudson, Nabeel Bardeesy, Lei Shi, Rahul M. Kohli, Meiqi Luo, Yi Sun, Russell W. Jenkins, Robert T. Manguso, Cristina R. Ferrone, Joshua Merritt
Publikováno v:
Cancer Discovery. 12:812-835
Isocitrate dehydrogenase 1 mutations (mIDH1) are common in cholangiocarcinoma. (R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits multiple α-ketoglutarate–dependent enzymes, altering epigenetics and metabolism. Here, by developing mIDH1
Autor:
Jian-Feng Liu, You Jin, Jian-Guo Chen, Lan Ni, Zhuang-Li Hu, Cong Ma, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Hui-Ling Zheng, Fang Wang, Wen-Long Xie, Hou-Hong Li
Publikováno v:
Biological Psychiatry. 91:593-603
Background Depression is a common psychiatric disorder associated with the defects in GABAergic neurotransmission. α-Dystroglycan (α-DG), a cell adhesion molecule known to be essential for skeletal muscle integrity, is also present at inhibitory sy
Publikováno v:
British Journal of Pharmacology. 179:2193-2207
Background and purpose Glucosylsphingosine (GS), an endogenous sphingolipid, is highly accumulated in the epidermis of patients with atopic dermatitis (AD) due to abnormal ceramide metabolism. More importantly, GS can evoke scratching behaviors. Howe